Entity Details

Primary name WNK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H4A3
EntryNameWNK1_HUMAN
FullNameSerine/threonine-protein kinase WNK1
TaxID9606
Evidenceevidence at protein level
Length2382
SequenceStatuscomplete
DateCreated2004-02-02
DateModified2021-06-02

Ontological Relatives

GenesWNK1

GO terms

Show/Hide Table
GOName
GO:0002028 regulation of sodium ion transport
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004860 protein kinase inhibitor activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006811 ion transport
GO:0007165 signal transduction
GO:0010766 negative regulation of sodium ion transport
GO:0010820 positive regulation of T cell chemotaxis
GO:0010923 negative regulation of phosphatase activity
GO:0016020 membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019869 chloride channel inhibitor activity
GO:0019870 potassium channel inhibitor activity
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0030295 protein kinase activator activity
GO:0033633 negative regulation of cell-cell adhesion mediated by integrin
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0034260 negative regulation of GTPase activity
GO:0035556 intracellular signal transduction
GO:0038116 chemokine (C-C motif) ligand 21 signaling pathway
GO:0048666 neuron development
GO:0050794 regulation of cellular process
GO:0050801 ion homeostasis
GO:0050852 T cell receptor signaling pathway
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097022 lymphocyte migration into lymph node
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903288 positive regulation of potassium ion import across plasma membrane
GO:1904062 regulation of cation transmembrane transport
GO:1990869 cellular response to chemokine
GO:2000651 positive regulation of sodium ion transmembrane transporter activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domainDomainDomain

Diseases

Show/Hide Table

Interactions

75 interactions

InteractorPartnerSourcesPublicationsLink
WNK1_HUMANATX1_HUMANBioGRID, HPRD, IntAct16713569 details
WNK1_HUMANGLIS2_HUMANBioGRID, MINT17289029 details
WNK1_HUMANOXSR1_HUMANDIP, MINT16832045 17721439 details
WNK1_HUMANMP2K1_HUMANBioGRID, IntAct20936779 details
WNK1_HUMAN1433E_HUMANBioGRID, IntAct20936779 details
WNK1_HUMAN1433G_HUMANBioGRID, HPRD, IntAct15324660 20936779 28514442 details
WNK1_HUMANCSN5_HUMANBioGRID, IntAct20936779 details
WNK1_HUMANNED4L_HUMANBioGRID, IntAct20525693 20936779 26241057 details
WNK1_HUMANWNK1_HUMANBioGRID, IntAct20936779 details
WNK1_HUMANWNK2_HUMANBioGRID, IntAct20936779 details
WNK1_HUMAN1433Z_HUMANBioGRID, IntAct20936779 details
WNK1_HUMANARAF_HUMANBioGRID, IntAct21988832 details
WNK1_HUMANPFKAP_HUMANBioGRID, IntAct21988832 details
WNK1_HUMANPVR_HUMANBioGRID, IntAct21988832 details
WNK1_HUMANPP1A_HUMANUniProt19389623 details
WNK1_HUMANTULP3_HUMANBioGRID, IntAct23414517 details
WNK1_HUMANE2F3_HUMANBioGRID12748276 details
WNK1_HUMANCLH1_HUMANBioGRID20936779 26496610 details
WNK1_HUMANFLNC_HUMANBioGRID20936779 details
WNK1_HUMANATP8_HUMANBioGRID20936779 details
WNK1_HUMANKAP0_HUMANBioGRID20936779 details
WNK1_HUMANKAP1_HUMANBioGRID20936779 details
WNK1_HUMANSL9A1_HUMANBioGRID20936779 details
WNK1_HUMANZYX_HUMANBioGRID20936779 34079125 details
WNK1_HUMANCSDE1_HUMANBioGRID20936779 details
WNK1_HUMANT22D1_HUMANBioGRID20936779 details
WNK1_HUMANBAG3_HUMANBioGRID20936779 details
WNK1_HUMANRANB9_HUMANBioGRID20936779 details
WNK1_HUMANTNR6A_HUMANBioGRID20936779 details
WNK1_HUMANZN106_HUMANBioGRID20936779 details
WNK1_HUMANKLHL3_HUMANBioGRID23387299 23576762 23838290 26286618 29904119 details
WNK1_HUMANKLHL2_HUMANBioGRID23838290 24641320 28514442 details
WNK1_HUMANRENT2_HUMANBioGRID15231747 details
WNK1_HUMANADRB2_HUMANBioGRID24561123 details
WNK1_HUMANFHL3_HUMANBioGRID25416956 32296183 details
WNK1_HUMANUBC9_HUMANBioGRID15561718 details
WNK1_HUMANMAOM_HUMANIntAct17353931 details
WNK1_HUMANBAD_HUMANIntAct20936779 details
WNK1_HUMANZN839_HUMANIntAct20936779 details
WNK1_HUMANFA13B_HUMANIntAct20936779 details
WNK1_HUMANRIPR2_HUMANIntAct20936779 details
WNK1_HUMANCENPJ_HUMANIntAct20936779 details
WNK1_HUMANCGNL1_HUMANIntAct20936779 details
WNK1_HUMANCAF1A_HUMANIntAct20936779 details
WNK1_HUMANE41L2_HUMANIntAct20936779 details
WNK1_HUMANEIF3A_HUMANIntAct20936779 details
WNK1_HUMANFHOD1_HUMANIntAct20936779 details
WNK1_HUMANRMD3_HUMANIntAct20936779 details
WNK1_HUMANHDAC9_HUMANIntAct20936779 details
WNK1_HUMANZEP2_HUMANIntAct20936779 details
WNK1_HUMANK0232_HUMANIntAct20936779 details
WNK1_HUMANLCP2_HUMANIntAct20936779 details
WNK1_HUMANIRAG2_HUMANIntAct20936779 details
WNK1_HUMANMADD_HUMANIntAct20936779 details
WNK1_HUMANMPP9_HUMANIntAct20936779 details
WNK1_HUMANMYH9_HUMANIntAct20936779 details
WNK1_HUMANMSL2_HUMANIntAct20936779 details
WNK1_HUMANITPI2_HUMANIntAct20936779 details
WNK1_HUMANSYNPO_HUMANIntAct20936779 details
WNK1_HUMANSYNP2_HUMANIntAct20936779 details
WNK1_HUMANTNAP3_HUMANIntAct20936779 details
WNK1_HUMANTENS1_HUMANIntAct20936779 details
WNK1_HUMANWWTR1_HUMANIntAct20936779 details
WNK1_HUMANRPGP2_HUMANIntAct20936779 details
WNK1_HUMANSIMC1_HUMANIntAct20936779 details
WNK1_HUMANFA53C_HUMANIntAct20936779 details
WNK1_HUMANRASL3_HUMANIntAct20936779 details
WNK1_HUMANPLEC_HUMANBioGRID, IntAct27173435 30021884 unassigned1312 details
WNK1_HUMANAAK1_HUMANBioGRID, IntAct27173435 unassigned1312 details
WNK1_HUMANSGK1_HUMANBioGRID16006511 20525693 details
WNK1_HUMAN1433T_HUMANBioGRID23444366 details
WNK1_HUMANSYT2_HUMANHPRD15350218 details
WNK1_HUMANAKT1_HUMANHPRD14611643 details
WNK1_HUMANM3K3_HUMANHPRD14681216 details
WNK1_HUMANM3K2_HUMANHPRD14681216 details