Entity Details

Primary name INSI1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO15503
EntryNameINSI1_HUMAN
FullNameInsulin-induced gene 1 protein
TaxID9606
Evidenceevidence at protein level
Length277
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesINSIG1

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006641 triglyceride metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0008142 oxysterol binding
GO:0010894 negative regulation of steroid biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0032869 cellular response to insulin stimulus
GO:0032933 SREBP signaling pathway
GO:0032937 SREBP-SCAP-Insig complex
GO:0036315 cellular response to sterol
GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum
GO:0042472 inner ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0042632 cholesterol homeostasis
GO:0045599 negative regulation of fat cell differentiation
GO:0045717 negative regulation of fatty acid biosynthetic process
GO:0060021 roof of mouth development
GO:0060363 cranial suture morphogenesis
GO:0070862 negative regulation of protein exit from endoplasmic reticulum
GO:1901303 negative regulation of cargo loading into COPII-coated vesicle

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR009904 Insulin-induced gene 1 proteinFamilyFamily
IPR025929 Insulin-induced protein familyFamilyFamily

Diseases

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Interactions

26 interactions

InteractorPartnerSourcesPublicationsLink
INSI1_HUMANTM237_HUMANBioGRID, IntAct32296183 details
INSI1_HUMANAQP6_HUMANBioGRID, IntAct32296183 details
INSI1_HUMANBKRB1_HUMANBioGRID, MINT28298427 details
INSI1_HUMAN5HT2B_HUMANBioGRID, MINT28298427 details
INSI1_HUMANFAF2_HUMANBioGRID18835813 19815544 23720822 details
INSI1_HUMANTERA_HUMANBioGRID16168377 18835813 19815544 details
INSI1_HUMANPRS6A_HUMANBioGRID19815544 details
INSI1_HUMANPSA7_HUMANBioGRID19815544 details
INSI1_HUMANPGRC1_HUMANBioGRID15782218 21081644 details
INSI1_HUMANPCKGC_HUMANBioGRID32322062 details
INSI1_HUMANAMFR_HUMANBioGRID, UniProt16168377 17043353 19815544 21343306 22143767 30733434 details
INSI1_HUMANERLN2_HUMANBioGRID, UniProt21343306 22690709 24217618 32322062 details
INSI1_HUMANVAPB_HUMANBioGRID, DIP16606821 details
INSI1_HUMANVAPA_HUMANBioGRID, DIP16606821 details
INSI1_HUMANSCAP_HUMANBioGRID, HPRD12202038 12242332 12482938 12842885 17043353 18835813 23564452 26555173 30563842 32111832 32322062 details
INSI1_HUMANSRBP2_HUMANBioGRID, HPRD12202038 12242332 12842885 details
INSI1_HUMANHMDH_HUMANBioGRID, HPRD12535518 16168377 19458199 20458442 21343306 23223569 24371122 details
INSI1_HUMANRN139_HUMANBioGRID20068067 22143767 30563842 details
INSI1_HUMANINSI1_HUMANBioGRID19617589 details
INSI1_HUMANINSI2_HUMANBioGRID19617589 details
INSI1_HUMANSRBP1_HUMANBioGRID12242332 details
INSI1_HUMANNCPR_HUMANBioGRID21081644 details
INSI1_HUMANERLN1_HUMANBioGRID24217618 details
INSI1_HUMANSOAT2_HUMANBioGRID28604676 details
INSI1_HUMANRN145_HUMANBioGRID29374057 details
INSI1_HUMANAAPK1_HUMANBioGRID30733434 details