Entity Details

Primary name AGO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9H9G7
EntryNameAGO3_HUMAN
FullNameProtein argonaute-3
TaxID9606
Evidenceevidence at protein level
Length860
SequenceStatuscomplete
DateCreated2003-11-14
DateModified2021-06-02

Ontological Relatives

GenesAGO3

GO terms

Show/Hide Table
GOName
GO:0000794 condensed nuclear chromosome
GO:0000932 P-body
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 endoribonuclease activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006402 mRNA catabolic process
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0010501 RNA secondary structure unwinding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0016020 membrane
GO:0016442 RISC complex
GO:0030522 intracellular receptor signaling pathway
GO:0031054 pre-miRNA processing
GO:0035194 post-transcriptional gene silencing by RNA
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035198 miRNA binding
GO:0035278 miRNA mediated inhibition of translation
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045652 regulation of megakaryocyte differentiation
GO:0046872 metal ion binding
GO:0060260 regulation of transcription initiation from RNA polymerase II promoter
GO:0070578 RISC-loading complex
GO:0072091 regulation of stem cell proliferation
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR003100 PAZ domainDomainDomain
IPR003165 Piwi domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014811 Argonaute, linker 1 domainDomainDomain
IPR028603 Protein argonaute-3FamilyFamily
IPR032472 Argonaute linker 2 domainDomainDomain
IPR032473 Protein argonaute, Mid domainDomainDomain
IPR032474 Protein argonaute, N-terminalDomainDomain
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

32 interactions

InteractorPartnerSourcesPublicationsLink
AGO3_HUMANTNR6B_HUMANBioGRID, IntAct, UniProt19167051 19383768 19470757 24043833 24778252 26496610 29395067 details
AGO3_HUMANIPO8_HUMANBioGRID, IntAct19167051 details
AGO3_HUMANATP4B_HUMANBioGRID, IntAct21988832 details
AGO3_HUMANBDNF_HUMANBioGRID, IntAct21988832 details
AGO3_HUMANS22A2_HUMANBioGRID, IntAct21988832 details
AGO3_HUMANVA0D2_HUMANBioGRID, IntAct21988832 details
AGO3_HUMANTNR6A_HUMANBioGRID, IntAct, UniProt19324964 19383768 19470757 24778252 26496610 28683311 28813667 29395067 details
AGO3_HUMANTNR6C_HUMANBioGRID, UniProt19383768 19470757 24778252 29395067 details
AGO3_HUMANOTUD4_HUMANBioGRID, IntAct19167051 29395067 details
AGO3_HUMANDICER_HUMANBioGRID, IntAct12906857 24778252 26496610 details
AGO3_HUMANPPP5_HUMANBioGRID, IntAct28330616 details
AGO3_HUMANEDC4_HUMANDIP23064648 details
AGO3_HUMANWTIP_HUMANUniProt28683311 details
AGO3_HUMANLIMD1_HUMANUniProt28683311 details
AGO3_HUMANATOH1_HUMANBioGRID27542412 details
AGO3_HUMANMEX3B_HUMANBioGRID29395067 details
AGO3_HUMANMOV10_HUMANBioGRID29395067 details
AGO3_HUMANPABP1_HUMANBioGRID29395067 details
AGO3_HUMANPATL1_HUMANBioGRID29395067 details
AGO3_HUMANPRC2A_HUMANBioGRID29395067 details
AGO3_HUMANPUM1_HUMANBioGRID29395067 details
AGO3_HUMANR3HD2_HUMANBioGRID29395067 details
AGO3_HUMANRBMS1_HUMANBioGRID29395067 details
AGO3_HUMANRC3H1_HUMANBioGRID29395067 details
AGO3_HUMANUBP2L_HUMANBioGRID29395067 details
AGO3_HUMANYTHD1_HUMANBioGRID29395067 details
AGO3_HUMANYTHD2_HUMANBioGRID29395067 details
AGO3_HUMANYTHD3_HUMANBioGRID29395067 details
AGO3_HUMANZ3H7A_HUMANBioGRID29395067 details
AGO3_HUMANZCCHV_HUMANBioGRID29395067 details
AGO3_HUMANTTP_HUMANBioGRID29395067 details
AGO3_HUMANMKRN2_HUMANBioGRID29395067 details