Entity Details

Primary name NSMA2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NY59
EntryNameNSMA2_HUMAN
FullNameSphingomyelin phosphodiesterase 3
TaxID9606
Evidenceevidence at protein level
Length655
SequenceStatuscomplete
DateCreated2005-08-30
DateModified2021-06-02

Ontological Relatives

GenesSMPD3

GO terms

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GOName
GO:0000137 Golgi cis cisterna
GO:0000139 Golgi membrane
GO:0001786 phosphatidylserine binding
GO:0001932 regulation of protein phosphorylation
GO:0001958 endochondral ossification
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002685 regulation of leukocyte migration
GO:0003433 chondrocyte development involved in endochondral bone morphogenesis
GO:0004620 phospholipase activity
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006672 ceramide metabolic process
GO:0006684 sphingomyelin metabolic process
GO:0006685 sphingomyelin catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0015774 polysaccharide transport
GO:0030072 peptide hormone secretion
GO:0030282 bone mineralization
GO:0030509 BMP signaling pathway
GO:0032963 collagen metabolic process
GO:0035264 multicellular organism growth
GO:0042802 identical protein binding
GO:0043491 protein kinase B signaling
GO:0045840 positive regulation of mitotic nuclear division
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048286 lung alveolus development
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0061035 regulation of cartilage development
GO:0061751 neutral sphingomyelin phosphodiesterase activity
GO:0070300 phosphatidic acid binding
GO:0070301 cellular response to hydrogen peroxide
GO:0070314 G1 to G0 transition
GO:0071286 cellular response to magnesium ion
GO:0071356 cellular response to tumor necrosis factor
GO:0071461 cellular response to redox state
GO:0071897 DNA biosynthetic process
GO:0085029 extracellular matrix assembly
GO:0090520 sphingolipid mediated signaling pathway
GO:0097187 dentinogenesis
GO:0098868 bone growth
GO:0140014 mitotic nuclear division
GO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1901653 cellular response to peptide
GO:1903543 positive regulation of exosomal secretion
GO:2000304 positive regulation of ceramide biosynthetic process

Subcellular Location

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Subcellular Location
Cell membrane
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR005135 Endonuclease/exonuclease/phosphataseDomainDomain
IPR017766 Sphingomyelinase C/phospholipase CFamilyFamily
IPR036691 Endonuclease/exonuclease/phosphatase superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00144 Phosphatidyl serineDrugbanksmall molecule