Entity Details

Primary name E2AK4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9P2K8
EntryNameE2AK4_HUMAN
FullNameeIF-2-alpha kinase GCN2
TaxID9606
Evidenceevidence at protein level
Length1649
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesEIF2AK4

GO terms

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GOName
GO:0000049 tRNA binding
GO:0000077 DNA damage checkpoint signaling
GO:0001934 positive regulation of protein phosphorylation
GO:0002230 positive regulation of defense response to virus by host
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002821 positive regulation of adaptive immune response
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005844 polysome
GO:0006446 regulation of translational initiation
GO:0006468 protein phosphorylation
GO:0007612 learning
GO:0007616 long-term memory
GO:0010998 regulation of translational initiation by eIF2 alpha phosphorylation
GO:0019081 viral translation
GO:0022626 cytosolic ribosome
GO:0032057 negative regulation of translational initiation in response to stress
GO:0032792 negative regulation of CREB transcription factor activity
GO:0034198 cellular response to amino acid starvation
GO:0034644 cellular response to UV
GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress
GO:0039520 induction by virus of host autophagy
GO:0044828 negative regulation by host of viral genome replication
GO:0045665 negative regulation of neuron differentiation
GO:0045947 negative regulation of translational initiation
GO:0046777 protein autophosphorylation
GO:0051607 defense response to virus
GO:0060259 regulation of feeding behavior
GO:0070417 cellular response to cold
GO:0071264 positive regulation of translational initiation in response to starvation
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0140469 GCN2-mediated signaling
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1990138 neuron projection extension
GO:1990253 cellular response to leucine starvation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR006575 RWD domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016135 Ubiquitin-conjugating enzyme/RWD-likeFamilyHomologous superfamily
IPR016255 eIF-2-alpha kinase Gcn2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR024435 Histidyl tRNA synthetase-related domainDomainDomain
IPR036621 Anticodon-binding domain superfamilyFamilyHomologous superfamily
IPR041715 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule