Entity Details

Primary name KLF4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43474
EntryNameKLF4_HUMAN
FullNameKrueppel-like factor 4
TaxID9606
Evidenceevidence at protein level
Length513
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesKLF4

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000791 euchromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001010 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity
GO:0001221 transcription coregulator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002357 defense response to tumor cell
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007500 mesodermal cell fate determination
GO:0008013 beta-catenin binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009913 epidermal cell differentiation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling
GO:0014740 negative regulation of muscle hyperplasia
GO:0016525 negative regulation of angiogenesis
GO:0019827 stem cell population maintenance
GO:0031077 post-embryonic camera-type eye development
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032717 negative regulation of interleukin-8 production
GO:0034115 negative regulation of heterotypic cell-cell adhesion
GO:0035014 phosphatidylinositol 3-kinase regulator activity
GO:0035019 somatic stem cell population maintenance
GO:0035166 post-embryonic hemopoiesis
GO:0042826 histone deacetylase binding
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045444 fat cell differentiation
GO:0045595 regulation of cell differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046985 positive regulation of hemoglobin biosynthetic process
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048679 regulation of axon regeneration
GO:0048730 epidermis morphogenesis
GO:0050728 negative regulation of inflammatory response
GO:0051247 positive regulation of protein metabolic process
GO:0051898 negative regulation of protein kinase B signaling
GO:0051973 positive regulation of telomerase activity
GO:0060070 canonical Wnt signaling pathway
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070301 cellular response to hydrogen peroxide
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0071300 cellular response to retinoic acid
GO:0071363 cellular response to growth factor stimulus
GO:0071409 cellular response to cycloheximide
GO:0071499 cellular response to laminar fluid shear stress
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:0120222 regulation of blastocyst development
GO:1901653 cellular response to peptide
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903672 positive regulation of sprouting angiogenesis
GO:1904798 positive regulation of core promoter binding
GO:1904998 negative regulation of leukocyte adhesion to arterial endothelial cell
GO:1990830 cellular response to leukemia inhibitory factor
GO:1990837 sequence-specific double-stranded DNA binding
GO:1990841 promoter-specific chromatin binding
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR013087 Zinc finger C2H2-typeDomainDomain
IPR036236 Zinc finger C2H2 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

46 interactions

InteractorPartnerSourcesPublicationsLink
KLF4_HUMANDVL3_HUMANBioGRID, IntAct32296183 details
KLF4_HUMANTLE5_HUMANBioGRID, IntAct32296183 details
KLF4_HUMANPAX9_HUMANBioGRID, IntAct32296183 details
KLF4_HUMANGYS1_HUMANBioGRID, IntAct32296183 details
KLF4_HUMANHGS_HUMANBioGRID, IntAct32296183 details
KLF4_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
KLF4_HUMANYAP1_HUMANDIP25531778 details
KLF4_HUMANCBP_HUMANBioGRID, HPRD10666450 17908689 21482710 21539536 details
KLF4_HUMANSP1_HUMANBioGRID, HPRD12034813 22282354 9651398 details
KLF4_HUMANHDAC2_HUMANBioGRID15561714 19486889 21252119 details
KLF4_HUMANHDAC1_HUMANBioGRID15561714 details
KLF4_HUMANEP300_HUMANBioGRID17908689 20711222 21252119 21482710 details
KLF4_HUMANKAT5_HUMANBioGRID17827213 details
KLF4_HUMANVHL_HUMANBioGRID22284679 details
KLF4_HUMANA4_HUMANBioGRID21832049 details
KLF4_HUMANSETD7_HUMANBioGRID25042802 details
KLF4_HUMANHUWE1_HUMANBioGRID28084302 details
KLF4_HUMANBAALC_HUMANBioGRID26050649 details
KLF4_HUMANFBX7_HUMANBioGRID27503909 details
KLF4_HUMANMY15B_HUMANBioGRID32296183 details
KLF4_HUMANPLK1_HUMANBioGRID31281496 details
KLF4_HUMANUBP10_HUMANBioGRID31748695 details
KLF4_HUMANCTBP1_HUMANBioGRID, MINT19751731 details
KLF4_HUMANKDM6B_HUMANDIP22801502 details
KLF4_HUMANKDM6A_HUMANDIP22801502 details
KLF4_HUMANMBD3_HUMANDIP24048479 details
KLF4_HUMANESR1_HUMANBioGRID, IntAct23403292 31527615 details
KLF4_HUMANKLF6_HUMANBioGRID, HPRD10802067 details
KLF4_HUMANELK1_HUMANBioGRID, HPRD18768922 details
KLF4_HUMANHDAC5_HUMANBioGRID, HPRD18768922 details
KLF4_HUMANHDAC7_HUMANBioGRID17827213 details
KLF4_HUMANSMCA4_HUMANBioGRID20305087 details
KLF4_HUMANPPARG_HUMANBioGRID22282354 details
KLF4_HUMANTF65_HUMANBioGRID22282354 details
KLF4_HUMANKPCD_HUMANBioGRID22282354 details
KLF4_HUMANCUL2_HUMANBioGRID22284679 details
KLF4_HUMANELOB_HUMANBioGRID22284679 details
KLF4_HUMANCADH1_HUMANBioGRID21177849 details
KLF4_HUMANFBX22_HUMANBioGRID26087183 details
KLF4_HUMANFBX32_HUMANBioGRID28068319 details
KLF4_HUMANTRAF6_HUMANBioGRID31281496 details
KLF4_HUMANUBP4_HUMANBioGRID31748695 details
KLF4_HUMANUBP6_HUMANBioGRID31748695 details
KLF4_HUMANUBP7_HUMANBioGRID31748695 details
KLF4_HUMANATX3_HUMANBioGRID31563563 details
KLF4_HUMANP53_HUMANHPRD10749849 details