Entity Details

Primary name HEY2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UBP5
EntryNameHEY2_HUMAN
FullNameHairy/enhancer-of-split related with YRPW motif protein 2
TaxID9606
Evidenceevidence at protein level
Length337
SequenceStatuscomplete
DateCreated2006-07-11
DateModified2021-06-02

Ontological Relatives

GenesHEY2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001570 vasculogenesis
GO:0003150 muscular septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003161 cardiac conduction system development
GO:0003180 aortic valve morphogenesis
GO:0003184 pulmonary valve morphogenesis
GO:0003186 tricuspid valve morphogenesis
GO:0003195 tricuspid valve formation
GO:0003198 epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation
GO:0003208 cardiac ventricle morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003222 ventricular trabecula myocardium morphogenesis
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007219 Notch signaling pathway
GO:0008134 transcription factor binding
GO:0009948 anterior/posterior axis specification
GO:0009952 anterior/posterior pattern specification
GO:0010460 positive regulation of heart rate
GO:0010621 negative regulation of transcription by transcription factor localization
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0014031 mesenchymal cell development
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0017053 transcription repressor complex
GO:0035910 ascending aorta morphogenesis
GO:0035912 dorsal aorta morphogenesis
GO:0036304 umbilical cord morphogenesis
GO:0042802 identical protein binding
GO:0042826 histone deacetylase binding
GO:0043565 sequence-specific DNA binding
GO:0045165 cell fate commitment
GO:0045607 regulation of inner ear auditory receptor cell differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:0050767 regulation of neurogenesis
GO:0051145 smooth muscle cell differentiation
GO:0055015 ventricular cardiac muscle cell development
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0060347 heart trabecula formation
GO:0060411 cardiac septum morphogenesis
GO:0060412 ventricular septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter
GO:0060716 labyrinthine layer blood vessel development
GO:0060842 arterial endothelial cell differentiation
GO:0060948 cardiac vascular smooth muscle cell development
GO:0060977 coronary vasculature morphogenesis
GO:0061156 pulmonary artery morphogenesis
GO:0061314 Notch signaling involved in heart development
GO:0065004 protein-DNA complex assembly
GO:0070168 negative regulation of biomineral tissue development
GO:0072359 circulatory system development
GO:0090102 cochlea development
GO:0097084 vascular associated smooth muscle cell development
GO:1990837 sequence-specific double-stranded DNA binding
GO:2000678 negative regulation of transcription regulatory region DNA binding
GO:2000723 negative regulation of cardiac vascular smooth muscle cell differentiation
GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2001212 regulation of vasculogenesis

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003650 Orange domainDomainDomain
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
HEY2_HUMANPLS1_HUMANBioGRID, HPRD, IntAct16189514 details
HEY2_HUMANSIR1_HUMANBioGRID, HPRD, UniProt12535671 details
HEY2_HUMANENOA_HUMANBioGRID, IntAct23414517 details
HEY2_HUMANATX1_HUMANBioGRID, IntAct23275563 details
HEY2_HUMANHD_HUMANBioGRID, IntAct23275563 details
HEY2_HUMANTRAF1_HUMANBioGRID, IntAct25416956 32296183 details
HEY2_HUMANRBPMS_HUMANBioGRID, IntAct25416956 details
HEY2_HUMANPDLI7_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA62_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA44_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA11_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA59_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANHSF2B_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANTRAF4_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA61_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA31_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANFHL5_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKRA81_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANKR111_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANHXA1_HUMANBioGRID, IntAct32296183 details
HEY2_HUMANHEY1_HUMANBioGRID, IntAct19802006 24366871 26186194 27129302 28514442 details
HEY2_HUMANHAND1_HUMANBioGRID, HPRD10924525 details
HEY2_HUMANNCOR1_HUMANBioGRID, HPRD11486045 details
HEY2_HUMANHDAC1_HUMANBioGRID, HPRD11486045 details
HEY2_HUMANHES1_HUMANBioGRID, HPRD11486045 details
HEY2_HUMANARNT_HUMANBioGRID, HPRD10692439 details
HEY2_HUMANASXL1_HUMANBioGRID32683582 details
HEY2_HUMANHAND2_HUMANHPRD10924525 details
HEY2_HUMANHDAC9_HUMANBioGRID11486045 details
HEY2_HUMANSIN3A_HUMANBioGRID, HPRD11486045 details
HEY2_HUMANCASP3_HUMANBioGRID17217622 details
HEY2_HUMANFBW1A_HUMANBioGRID17217622 details
HEY2_HUMANSYVN1_HUMANBioGRID24366871 details
HEY2_HUMANSE1L1_HUMANBioGRID24366871 details
HEY2_HUMANDERL2_HUMANBioGRID24366871 details
HEY2_HUMANFBSP1_HUMANBioGRID26068074 details
HEY2_HUMANHEY2_HUMANHPRD11486045 details