Entity Details

Primary name FOXO3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43524
EntryNameFOXO3_HUMAN
FullNameForkhead box protein O3
TaxID9606
Evidenceevidence at protein level
Length673
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesFOXO3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006390 mitochondrial transcription
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0008013 beta-catenin binding
GO:0010508 positive regulation of autophagy
GO:0014737 positive regulation of muscle atrophy
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030336 negative regulation of cell migration
GO:0031490 chromatin DNA binding
GO:0032991 protein-containing complex
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034246 mitochondrial transcription factor activity
GO:0034599 cellular response to oxidative stress
GO:0042149 cellular response to glucose starvation
GO:0042594 response to starvation
GO:0043065 positive regulation of apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0070542 response to fatty acid
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion matrix
Mitochondrion outer membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001766 Fork head domainDomainDomain
IPR030456 Fork head domain conserved site 2SiteConserved site
IPR032067 FOXO protein, transactivation domainDomainDomain
IPR032068 FOXO protein, KIX-binding domainDomainDomain
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

57 interactions

InteractorPartnerSourcesPublicationsLink
FOXO3_HUMANAKT1_HUMANBioGRID, HPRD, IntAct, MINT, NTNU10102273 21621563 21775285 25241761 details
FOXO3_HUMANESR1_HUMANHPRD, IntAct11435445 16809346 18312651 21602804 details
FOXO3_HUMANSMAD4_HUMANBioGRID, HPRD, I2D, IntAct15084259 21532621 details
FOXO3_HUMANSMAD3_HUMANBioGRID, HPRD, I2D, IntAct15084259 21532621 24920680 details
FOXO3_HUMANSIR1_HUMANBioGRID, HPRD, UniProt14976264 15126506 20733005 21713995 details
FOXO3_HUMANP53_HUMANBioGRID, IntAct, UniProt14976264 18824006 25241761 27886165 details
FOXO3_HUMANCBP_HUMANBioGRID, MINT, UniProt15126506 22474372 25609649 details
FOXO3_HUMANMK06_HUMANBioGRID, MINT21900206 details
FOXO3_HUMANCDK6_HUMANBioGRID, IntAct22094256 details
FOXO3_HUMANIKKB_HUMANBioGRID, HPRD, IntAct15084260 25241761 details
FOXO3_HUMANATM_HUMANBioGRID18344987 details
FOXO3_HUMANVDR_HUMANBioGRID20733005 details
FOXO3_HUMANNR1H2_HUMANBioGRID, HPRD15604093 details
FOXO3_HUMANNR1H3_HUMANBioGRID, HPRD15604093 details
FOXO3_HUMANSKP2_HUMANBioGRID21841822 22310285 details
FOXO3_HUMANFBW1A_HUMANBioGRID20625400 details
FOXO3_HUMANMK01_HUMANBioGRID18204439 details
FOXO3_HUMANCDT1_HUMANBioGRID22451935 details
FOXO3_HUMANIKKA_HUMANBioGRID, HPRD15084260 details
FOXO3_HUMANERBIN_HUMANBioGRID15123239 details
FOXO3_HUMANPLK1_HUMANBioGRID25659891 26280018 details
FOXO3_HUMANPTPA_HUMANBioGRID26280018 30513302 details
FOXO3_HUMANTERT_HUMANBioGRID26370108 details
FOXO3_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct, MINT, NTNU10102273 11864996 17389761 28514442 details
FOXO3_HUMANFOXM1_HUMANIntAct16809346 details
FOXO3_HUMANSIR3_HUMANBioGRID, UniProt18781224 details
FOXO3_HUMANPIM1_HUMANMINT18593906 details
FOXO3_HUMAN1433E_HUMANBioGRID, IntAct17979178 20562859 26280018 details
FOXO3_HUMANATGA1_HUMANBioGRID, IntAct20562859 23640897 details
FOXO3_HUMANHCFC1_HUMANUniProt21909281 details
FOXO3_HUMANHCFC2_HUMANUniProt21909281 details
FOXO3_HUMAN2AAA_HUMANBioGRID, MINT20110348 26280018 details
FOXO3_HUMANEP300_HUMANBioGRID, HPRD, MINT11896584 19592618 25609649 details
FOXO3_HUMANCBY1_HUMANBioGRID, IntAct27173435 unassigned1312 details
FOXO3_HUMANMYC_HUMANBioGRID, NTNU18393360 details
FOXO3_HUMAN1433T_HUMANBioGRID, IntAct11896584 28514442 details
FOXO3_HUMAN1433G_HUMANHPRD, IntAct15324660 28514442 details
FOXO3_HUMANHIF1A_HUMANDIP18268343 details
FOXO3_HUMANCTNB1_HUMANBioGRID, IntAct15905404 29361949 details
FOXO3_HUMANESR2_HUMANBioGRID, IntAct18312651 29509190 details
FOXO3_HUMANUBP7_HUMANBioGRID16964248 26280018 details
FOXO3_HUMANH2AX_HUMANBioGRID18344987 details
FOXO3_HUMANBRCA1_HUMANBioGRID18344987 details
FOXO3_HUMANRAD17_HUMANBioGRID18344987 details
FOXO3_HUMANFACD2_HUMANBioGRID20040763 details
FOXO3_HUMANSTK4_HUMANBioGRID21715626 details
FOXO3_HUMANSMAD1_HUMANBioGRID17289590 details
FOXO3_HUMANNLK_HUMANBioGRID20874444 details
FOXO3_HUMANMDM2_HUMANBioGRID18204439 19321440 27886165 29676828 details
FOXO3_HUMANPCNA_HUMANBioGRID22451935 details
FOXO3_HUMANARRB1_HUMANBioGRID29676828 details
FOXO3_HUMANSIR6_HUMANBioGRID30542728 details
FOXO3_HUMANBBC3B_HUMANBioGRID25457551 details
FOXO3_HUMANBBC3_HUMANBioGRID25457551 details
FOXO3_HUMANSMAD2_HUMANHPRD15084259 details
FOXO3_HUMANSGK1_HUMANHPRD11154281 details
FOXO3_HUMANFOXG1_HUMANHPRD15084259 details