Entity Details

Primary name DCX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO43602
EntryNameDCX_HUMAN
FullNameNeuronal migration protein doublecortin
TaxID9606
Evidenceevidence at protein level
Length365
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesDCX

GO terms

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GOName
GO:0001764 neuron migration
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005930 axoneme
GO:0007399 nervous system development
GO:0007417 central nervous system development
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0035082 axoneme assembly
GO:0035556 intracellular signal transduction
GO:0042461 photoreceptor cell development
GO:0043005 neuron projection
GO:0060041 retina development in camera-type eye

Subcellular Location

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Subcellular Location
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR003533 Doublecortin domainDomainDomain
IPR017302 Neuronal migration protein doublecortin, chordataFamilyFamily
IPR036572 Doublecortin domain superfamilyFamilyHomologous superfamily
IPR040163 RP1/RP1L1/DCXFamilyFamily

Diseases

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Disease IDSourceNameDescription
300067 OMIMLissencephaly, X-linked 1 (LISX1)A classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'. The disease is caused by variants affecting the gene represented in this entry.
300067 OMIMLissencephaly, X-linked 1 (LISX1)A classic lissencephaly characterized by mental retardation and seizures that are more severe in male patients. Affected boys show an abnormally thick cortex with absent or severely reduced gyri. Clinical manifestations include feeding problems, abnormal muscular tone, seizures and severe to profound psychomotor retardation. Female patients display a less severe phenotype referred to as 'doublecortex'. The disease is caused by variants affecting the gene represented in this entry.

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
DCX_HUMANGOGA2_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
DCX_HUMANIKZF1_HUMANBioGRID, IntAct, MINT21516116 25416956 32296183 details
DCX_HUMANZBTB5_HUMANBioGRID, IntAct25416956 32296183 details
DCX_HUMANTRI27_HUMANBioGRID, IntAct25416956 details
DCX_HUMANTRI23_HUMANBioGRID, IntAct25416956 details
DCX_HUMANMEOX1_HUMANBioGRID, IntAct25416956 32296183 details
DCX_HUMANKR108_HUMANBioGRID, IntAct25416956 details
DCX_HUMANCACO2_HUMANBioGRID, IntAct25416956 details
DCX_HUMANK1C40_HUMANBioGRID, IntAct25416956 details
DCX_HUMANRINT1_HUMANBioGRID, IntAct25416956 31515488 details
DCX_HUMANSPAG5_HUMANBioGRID, IntAct25416956 details
DCX_HUMANKIFC3_HUMANBioGRID, IntAct25416956 details
DCX_HUMANTRIM1_HUMANBioGRID, IntAct21516116 25416956 32296183 details
DCX_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
DCX_HUMANTINF2_HUMANbhf-ucl, BioGRID21044950 details
DCX_HUMANACD_HUMANbhf-ucl, BioGRID21044950 details
DCX_HUMANPOTE1_HUMANbhf-ucl, BioGRID21044950 details
DCX_HUMANMTUS2_HUMANBioGRID, IntAct30886144 32296183 details
DCX_HUMANZRAN1_HUMANBioGRID, IntAct32296183 details
DCX_HUMANBICD2_HUMANBioGRID, IntAct32296183 details
DCX_HUMANVPS52_HUMANBioGRID, IntAct32296183 details
DCX_HUMANFSD2_HUMANBioGRID, IntAct32296183 details
DCX_HUMANZBT10_HUMANBioGRID, IntAct32296183 details
DCX_HUMANHOOK2_HUMANBioGRID, IntAct32296183 details
DCX_HUMANMK09_HUMANBioGRID, IntAct32296183 details
DCX_HUMANLIS1_HUMANBioGRID, HPRD11001923 12885786 details
DCX_HUMANDCX_HUMANBioGRID, HPRD11001923 details
DCX_HUMANUSP9X_HUMANBioGRID, HPRD15607950 details
DCX_HUMANOSTP_HUMANBioGRID22779921 details
DCX_HUMANNEB2_HUMANBioGRID, HPRD14550532 17178868 17482550 19094064 details
DCX_HUMANA4_HUMANBioGRID21832049 details
DCX_HUMANFBX25_HUMANBioGRID23940030 details
DCX_HUMANRBM5_HUMANBioGRID30217970 details
DCX_HUMANMEOX2_HUMANBioGRID32296183 details
DCX_HUMANAP1M1_HUMANHPRD11591131 details
DCX_HUMANAP2M1_HUMANHPRD11591131 details
DCX_HUMANPP1A_HUMANBioGRID, HPRD19094064 details
DCX_HUMANKLH15_HUMANBioGRID33199366 details
DCX_HUMANNFASC_HUMANHPRD12223548 details
DCX_HUMANCDK5_HUMANHPRD14741103 15345747 details
DCX_HUMANTRI39_HUMANHPRD19094064 details