Entity Details

Primary name FZR1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UM11
EntryNameFZR1_HUMAN
FullNameFizzy-related protein homolog
TaxID9606
Evidenceevidence at protein level
Length496
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesFZR1

GO terms

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GOName
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006281 DNA repair
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007049 cell cycle
GO:0008284 positive regulation of cell population proliferation
GO:0010997 anaphase-promoting complex binding
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031965 nuclear membrane
GO:0040020 regulation of meiotic nuclear division
GO:0045732 positive regulation of protein catabolic process
GO:0051301 cell division
GO:0070306 lens fiber cell differentiation
GO:0070979 protein K11-linked ubiquitination
GO:0090344 negative regulation of cell aging
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1904668 positive regulation of ubiquitin protein ligase activity
GO:1905786 positive regulation of anaphase-promoting complex-dependent catabolic process
GO:1990757 ubiquitin ligase activator activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR024977 Anaphase-promoting complex subunit 4, WD40 domainDomainDomain
IPR033010 The WD repeat Cdc20/Fizzy familyFamilyFamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

169 interactions

InteractorPartnerSourcesPublicationsLink
FZR1_HUMANCG025_HUMANHPRD, IntAct16169070 details
FZR1_HUMANDNJA1_HUMANHPRD, IntAct16169070 details
FZR1_HUMANMD2L2_HUMANBioGRID, IntAct11459826 17719540 24100295 details
FZR1_HUMANCLSPN_HUMANBioGRID, IntAct18662541 19477924 details
FZR1_HUMANCDC27_HUMANBioGRID, DIP, HPRD, IntAct11340163 12097298 12797865 12956947 16479161 17187060 17609108 17942546 18372912 18662541 20395298 20663873 21186364 21241890 21768287 21986944 22014574 23029392 23160376 23670162 23972993 24100295 24811168 25306918 26963853 28514442 29700288 30498084 32076268 32152539 32345958 9637688 9734353 9811605 details
FZR1_HUMANCDC16_HUMANBioGRID, IntAct12956947 20360068 26496610 28514442 31420536 details
FZR1_HUMANCDC23_HUMANBioGRID, IntAct12956947 20360068 26496610 28514442 31420536 details
FZR1_HUMANCDC26_HUMANBioGRID, IntAct12956947 20360068 25723520 28514442 details
FZR1_HUMANVHL_HUMANBioGRID, I2D20802534 details
FZR1_HUMANMYC_HUMANBioGRID, IntAct21150319 28205554 details
FZR1_HUMANSIR2_HUMANBioGRID, IntAct22014574 details
FZR1_HUMANMAK_HUMANBioGRID, UniProt21986944 details
FZR1_HUMANSKP2_HUMANBioGRID, HPRD, IntAct15014502 15014503 19270695 19686743 20663873 21212736 22770219 23972993 28514442 31806563 details
FZR1_HUMANCCNB1_HUMANBioGRID, HPRD, IntAct11562349 11598127 12956947 14701726 16921029 19475398 20080579 20383333 21241890 21700221 22014574 22529100 23670162 23708605 24163370 25161877 25241761 25306923 25490258 25825779 27114510 27259151 28514442 29973362 31350353 32165494 32393902 details
FZR1_HUMANANC2_HUMANBioGRID, DIP, HPRD, IntAct12956947 16287863 21135578 25043029 26083744 28514442 9811605 details
FZR1_HUMANAPC4_HUMANBioGRID, DIP, IntAct12956947 23078409 25043029 25673878 26083744 28514442 details
FZR1_HUMANAPC5_HUMANBioGRID, IntAct12956947 23160376 28514442 details
FZR1_HUMANAPC1_HUMANBioGRID, IntAct12956947 28514442 details
FZR1_HUMANCDK2_HUMANBioGRID, HPRD, IntAct11340163 12560341 23670162 23972993 26083744 28514442 details
FZR1_HUMANCCNA2_HUMANBioGRID, IntAct18485873 19483727 21700221 26186194 27653696 28514442 31455778 31489637 details
FZR1_HUMANCDK1_HUMANBioGRID, IntAct20581839 28514442 details
FZR1_HUMANKITH_HUMANBioGRID, IntAct14701726 17227951 28514442 details
FZR1_HUMANFBX5_HUMANBioGRID, DIP, HPRD, IntAct11751633 11988738 16921029 23708001 28514442 29875408 details
FZR1_HUMANUBE2S_HUMANBioGRID, DIP19822757 23708001 25306918 25306923 details
FZR1_HUMANCC14A_HUMANBioGRID, HPRD11598127 details
FZR1_HUMANCDT1_HUMANBioGRID18162579 details
FZR1_HUMANCDC20_HUMANBioGRID16287863 17403670 23091007 23643811 details
FZR1_HUMANHSF2_HUMANBioGRID20937767 details
FZR1_HUMANCDC6_HUMANBioGRID10995389 14701726 21768287 details
FZR1_HUMANPIM1_HUMANBioGRID20663873 details
FZR1_HUMANCCNA1_HUMANBioGRID11340163 19477924 23972993 31420536 details
FZR1_HUMANCDK5_HUMANBioGRID18818692 22654103 23589330 details
FZR1_HUMANE2F1_HUMANBioGRID22580462 27903963 details
FZR1_HUMANMK08_HUMANBioGRID20581839 details
FZR1_HUMANMPIP1_HUMANBioGRID12234927 19477924 details
FZR1_HUMANE2F3_HUMANBioGRID22580460 details
FZR1_HUMANMOAP1_HUMANBioGRID22529100 details
FZR1_HUMANPTTG1_HUMANBioGRID10922056 11562349 12956947 16479161 18485873 20080579 21700221 23091007 23707760 23708001 24930963 25490258 25825779 27114510 27259151 29549242 29973362 32393902 details
FZR1_HUMANGEMI_HUMANBioGRID11562349 21700221 29875408 details
FZR1_HUMANUBE2C_HUMANBioGRID18485873 19822757 21700221 details
FZR1_HUMANUB2D1_HUMANBioGRID18485873 details
FZR1_HUMANUB2D3_HUMANBioGRID18485873 details
FZR1_HUMANUBE2K_HUMANBioGRID18485873 details
FZR1_HUMANSMUF1_HUMANBioGRID22152476 22949615 details
FZR1_HUMANBUB1B_HUMANBioGRID23091007 25505175 details
FZR1_HUMANAPC11_HUMANBioGRID12956947 18662541 details
FZR1_HUMANPTEN_HUMANBioGRID21241890 24811168 details
FZR1_HUMANFBW1A_HUMANBioGRID23972993 32345958 details
FZR1_HUMANPLK1_HUMANBioGRID21700221 23160376 23972993 26387737 details
FZR1_HUMANSOX2_HUMANBioGRID23972993 details
FZR1_HUMANHECW2_HUMANBioGRID24163370 details
FZR1_HUMANP53_HUMANBioGRID10922056 details
FZR1_HUMANNIPA_HUMANBioGRID22205987 details
FZR1_HUMANCDR2_HUMANBioGRID20383333 details
FZR1_HUMANCTIP_HUMANBioGRID25349192 details
FZR1_HUMANUBP1_HUMANBioGRID21768287 23589330 details
FZR1_HUMANDCPS_HUMANBioGRID25043029 27120157 27601667 details
FZR1_HUMANDNM1L_HUMANBioGRID21325626 details
FZR1_HUMANAPC7_HUMANBioGRID12956947 23160376 details
FZR1_HUMANAPC10_HUMANBioGRID12956947 details
FZR1_HUMANTACC3_HUMANBioGRID19823035 25375378 details
FZR1_HUMANCASL_HUMANBioGRID15144564 23539442 details
FZR1_HUMANNEK2_HUMANBioGRID23160376 25673878 26387737 details
FZR1_HUMANSENP2_HUMANBioGRID25483061 details
FZR1_HUMANBEX1_HUMANBioGRID25640309 details
FZR1_HUMANBLID_HUMANBioGRID25640309 details
FZR1_HUMANCCL5_HUMANBioGRID25640309 details
FZR1_HUMANCP17A_HUMANBioGRID25640309 details
FZR1_HUMANDKK3_HUMANBioGRID25640309 details
FZR1_HUMANESIP1_HUMANBioGRID25640309 details
FZR1_HUMANMTA3_HUMANBioGRID25640309 details
FZR1_HUMANARY2_HUMANBioGRID25640309 details
FZR1_HUMANHOP2_HUMANBioGRID25640309 details
FZR1_HUMANTHRSP_HUMANBioGRID25640309 details
FZR1_HUMANPAX3_HUMANBioGRID26329581 details
FZR1_HUMANPAF15_HUMANBioGRID21700221 details
FZR1_HUMANCCNF_HUMANBioGRID27653696 details
FZR1_HUMANOTU7B_HUMANBioGRID29973362 details
FZR1_HUMANKI18B_HUMANBioGRID29549242 details
FZR1_HUMANTP4A3_HUMANBioGRID30498084 details
FZR1_HUMANAURKA_HUMANBioGRID28205554 30498084 details
FZR1_HUMANAKT1_HUMANBioGRID28205554 details
FZR1_HUMANARNT_HUMANBioGRID28205554 details
FZR1_HUMANCDK6_HUMANBioGRID28205554 details
FZR1_HUMANCDN2A_HUMANBioGRID28205554 details
FZR1_HUMANARF_HUMANBioGRID28205554 details
FZR1_HUMANCDN2B_HUMANBioGRID28205554 details
FZR1_HUMANEPHA2_HUMANBioGRID28205554 details
FZR1_HUMANERBB2_HUMANBioGRID28205554 details
FZR1_HUMANFGFR4_HUMANBioGRID28205554 details
FZR1_HUMANFZR1_HUMANBioGRID28205554 details
FZR1_HUMANLATS2_HUMANBioGRID28205554 details
FZR1_HUMANSTK11_HUMANBioGRID28205554 details
FZR1_HUMANTERT_HUMANBioGRID28205554 details
FZR1_HUMANAKTS1_HUMANBioGRID28205554 details
FZR1_HUMANBECN1_HUMANBioGRID28205554 details
FZR1_HUMANCCND2_HUMANBioGRID28205554 details
FZR1_HUMANCCNE1_HUMANBioGRID28205554 details
FZR1_HUMANCDK4_HUMANBioGRID28205554 details
FZR1_HUMANHIF1A_HUMANBioGRID28205554 details
FZR1_HUMANKAT2A_HUMANBioGRID28205554 details
FZR1_HUMANMP2K3_HUMANBioGRID28205554 details
FZR1_HUMANM3K5_HUMANBioGRID28205554 details
FZR1_HUMANMET_HUMANBioGRID28205554 details
FZR1_HUMANMERL_HUMANBioGRID28205554 details
FZR1_HUMANPGFRA_HUMANBioGRID28205554 details
FZR1_HUMANTEAD2_HUMANBioGRID28205554 details
FZR1_HUMANGLIS2_HUMANBioGRID28205554 details
FZR1_HUMANMP2K5_HUMANBioGRID28205554 details
FZR1_HUMANRASF1_HUMANBioGRID28205554 details
FZR1_HUMANSOX4_HUMANBioGRID28205554 details
FZR1_HUMANSRC_HUMANBioGRID31420536 details
FZR1_HUMANSAS6_HUMANBioGRID31722219 details
FZR1_HUMANCHK1_HUMANBioGRID32345958 details
FZR1_HUMANCC14B_HUMANBioGRID, IntAct18662541 details
FZR1_HUMANRAD17_HUMANMINT20424596 details
FZR1_HUMANRIR2_HUMANBioGRID, IntAct22632967 26186194 28514442 details
FZR1_HUMANUBP37_HUMANBioGRID, IntAct21596315 25347529 28514442 details
FZR1_HUMANCUED2_HUMANBioGRID, IntAct23776205 26186194 28514442 details
FZR1_HUMANSKIL_HUMANBioGRID, HPRD11691834 details
FZR1_HUMANTPX2_HUMANBioGRID16287863 details
FZR1_HUMANIST1_HUMANBioGRID21439932 details
FZR1_HUMANCSF3R_HUMANBioGRID17001306 details
FZR1_HUMANKMT5A_HUMANBioGRID20966048 details
FZR1_HUMANGRIA1_HUMANBioGRID21186356 details
FZR1_HUMANEPHA4_HUMANBioGRID21186356 details
FZR1_HUMANT2R13_HUMANBioGRID20064487 details
FZR1_HUMANRB_HUMANBioGRID17187060 details
FZR1_HUMANID1_HUMANBioGRID18372912 details
FZR1_HUMANNINL_HUMANBioGRID17403670 details
FZR1_HUMANSIX1_HUMANBioGRID17130831 details
FZR1_HUMANFOXM1_HUMANBioGRID18573889 18758239 24362530 details
FZR1_HUMANRNF34_HUMANBioGRID21903591 details
FZR1_HUMANCKAP2_HUMANBioGRID17339342 details
FZR1_HUMANCKS1_HUMANBioGRID15014502 details
FZR1_HUMANAURKB_HUMANBioGRID15923616 29449677 details
FZR1_HUMANEMIL1_HUMANBioGRID17609108 details
FZR1_HUMANDDB1_HUMANBioGRID20395298 details
FZR1_HUMANBRSK2_HUMANBioGRID23029325 details
FZR1_HUMANSPRTN_HUMANBioGRID23042605 details
FZR1_HUMANRHG32_HUMANBioGRID23226367 details
FZR1_HUMANDAXX_HUMANBioGRID23239745 details
FZR1_HUMANEYA1_HUMANBioGRID23263983 details
FZR1_HUMANPHF8_HUMANBioGRID23979597 details
FZR1_HUMANCUL1_HUMANBioGRID23972993 details
FZR1_HUMANRGAP1_HUMANBioGRID23696789 details
FZR1_HUMANSTAU1_HUMANBioGRID24906885 details
FZR1_HUMANFACD2_HUMANBioGRID22854063 details
FZR1_HUMANTTK_HUMANBioGRID20729194 details
FZR1_HUMANTRI33_HUMANBioGRID23160376 details
FZR1_HUMANFMR1_HUMANBioGRID25913861 details
FZR1_HUMANPRKN_HUMANBioGRID26387737 details
FZR1_HUMANPRKDC_HUMANBioGRID26221070 details
FZR1_HUMANCCND1_HUMANBioGRID20439707 details
FZR1_HUMANMCPH1_HUMANBioGRID29150431 details
FZR1_HUMANRN157_HUMANBioGRID28655764 details
FZR1_HUMANNUP98_HUMANBioGRID27097363 details
FZR1_HUMANHXD13_HUMANBioGRID27097363 details
FZR1_HUMANLNP1_HUMANBioGRID27097363 details
FZR1_HUMANHHEX_HUMANBioGRID27097363 details
FZR1_HUMANGLSK_HUMANBioGRID27902968 details
FZR1_HUMANANDR_HUMANBioGRID27312068 details
FZR1_HUMANSPOP_HUMANBioGRID29160310 details
FZR1_HUMANUBP35_HUMANBioGRID29449677 details
FZR1_HUMANFBX31_HUMANBioGRID29343641 details
FZR1_HUMANXPO1_HUMANBioGRID31420536 details
FZR1_HUMANWDR5_HUMANBioGRID32076268 details
FZR1_HUMANCP24A_HUMANBioGRID32165494 details
FZR1_HUMANPECA1_HUMANBioGRID31489637 details