Entity Details

Primary name MACF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UPN3
EntryNameMACF1_HUMAN
FullNameMicrotubule-actin cross-linking factor 1, isoforms 1/2/3/5
TaxID9606
Evidenceevidence at protein level
Length7388
SequenceStatuscomplete
DateCreated2001-06-01
DateModified2021-06-02

Ontological Relatives

GenesMACF1

GO terms

Show/Hide Table
GOName
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0010632 regulation of epithelial cell migration
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016055 Wnt signaling pathway
GO:0016887 ATP hydrolysis activity
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030334 regulation of cell migration
GO:0032587 ruffle membrane
GO:0032886 regulation of microtubule-based process
GO:0042060 wound healing
GO:0043001 Golgi to plasma membrane protein transport
GO:0045104 intermediate filament cytoskeleton organization
GO:0045296 cadherin binding
GO:0045773 positive regulation of axon extension
GO:0051011 microtubule minus-end binding
GO:0051015 actin filament binding
GO:0051893 regulation of focal adhesion assembly
GO:0150011 regulation of neuron projection arborization

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus

Domains

Show/Hide Table
DomainNameCategoryType
IPR001101 Plectin repeatRepeatRepeat
IPR001452 SH3 domainDomainDomain
IPR001589 Actinin-type actin-binding domain, conserved siteSiteConserved site
IPR001715 Calponin homology domainDomainDomain
IPR002017 Spectrin repeatRepeatRepeat
IPR002048 EF-hand domainDomainDomain
IPR003108 GAR domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018159 Spectrin/alpha-actininRepeatRepeat
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR035915 Plakin repeat superfamilyFamilyHomologous superfamily
IPR036534 GAR domain superfamilyFamilyHomologous superfamily
IPR036872 CH domain superfamilyFamilyHomologous superfamily
IPR041573 Desmoplakin, spectrin-like domainDomainDomain
IPR041615 Desmoplakin, SH3 domainDomainDomain
IPR043197 PlakinFamilyFamily

Diseases

Show/Hide Table

Interactions

41 interactions

InteractorPartnerSourcesPublicationsLink
MACF1_HUMANNRCAM_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANNRX1A_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANPLXD1_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANCNTP2_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANNRX2A_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANTNG6_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANCNTP4_HUMANBioGRID, IntAct12421765 details
MACF1_HUMANSKIL_HUMANBioGRID, MINT15231748 details
MACF1_HUMANMCAF1_HUMANMINT15231748 details
MACF1_HUMANDISC1_HUMANBioGRID, IntAct17043677 31413325 details
MACF1_HUMANDTBP1_HUMANBioGRID, IntAct17043677 details
MACF1_HUMANEXOC1_HUMANBioGRID, IntAct17043677 31413325 details
MACF1_HUMANCDC5L_HUMANBioGRID, MINT17043677 20467437 details
MACF1_HUMANAPC_HUMANBioGRID, IntAct20936779 details
MACF1_HUMANJUN_HUMANBioGRID, IntAct20936779 details
MACF1_HUMANMK09_HUMANBioGRID, IntAct20936779 details
MACF1_HUMANFHL1_HUMANBioGRID, IntAct23414517 details
MACF1_HUMANSNAPN_HUMANBioGRID, IntAct23414517 details
MACF1_HUMANSNP47_HUMANIntAct26359495 details
MACF1_HUMANMTR1B_HUMANBioGRID, IntAct26514267 details
MACF1_HUMANMARE1_HUMANBioGRID, IntAct23001180 26186194 28514442 34079125 details
MACF1_HUMANTNIK_HUMANBioGRID, IntAct17043677 31413325 details
MACF1_HUMANCEP63_HUMANBioGRID, IntAct17043677 31413325 details
MACF1_HUMANMIPT3_HUMANBioGRID, IntAct17043677 31413325 details
MACF1_HUMANERR1_HUMANBioGRID15604093 details
MACF1_HUMANNRX1B_HUMANBioGRID12421765 details
MACF1_HUMANNRX2B_HUMANBioGRID12421765 details
MACF1_HUMANKPCD_HUMANBioGRID20395553 details
MACF1_HUMANSRPK2_HUMANBioGRID26167880 details
MACF1_HUMANUBC_HUMANBioGRID28190767 details
MACF1_HUMANTEN1_HUMANBioGRID25648896 details
MACF1_HUMANSAP18_HUMANIntAct17353931 details
MACF1_HUMAN3MG_HUMANIntAct17353931 details
MACF1_HUMANOPTN_HUMANIntAct20195357 details
MACF1_HUMANRAB21_HUMANIntAct22705394 details
MACF1_HUMANFMR1_HUMANIntAct31413325 details
MACF1_HUMANCD2AP_HUMANIntAct31413325 details
MACF1_HUMANCHP3_HUMANIntAct31413325 details
MACF1_HUMANTERF2_HUMANBioGRID20811636 details
MACF1_HUMANABCE1_HUMANBioGRID25659154 details
MACF1_HUMANATOH1_HUMANBioGRID27542412 details