Entity Details

Primary name SH2B3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UQQ2
EntryNameSH2B3_HUMAN
FullNameSH2B adapter protein 3
TaxID9606
Evidenceevidence at protein level
Length575
SequenceStatuscomplete
DateCreated2001-04-27
DateModified2021-06-02

Ontological Relatives

GenesSH2B3

GO terms

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GOName
GO:0001780 neutrophil homeostasis
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005173 stem cell factor receptor binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell population proliferation
GO:0019221 cytokine-mediated signaling pathway
GO:0030159 signaling receptor complex adaptor activity
GO:0035162 embryonic hemopoiesis
GO:0035556 intracellular signal transduction
GO:0035702 monocyte homeostasis
GO:0035855 megakaryocyte development
GO:0036016 cellular response to interleukin-3
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein
GO:0043407 negative regulation of MAP kinase activity
GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT
GO:0048821 erythrocyte development
GO:0051898 negative regulation of protein kinase B signaling
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070100 negative regulation of chemokine-mediated signaling pathway
GO:0090331 negative regulation of platelet aggregation
GO:1900235 negative regulation of Kit signaling pathway
GO:1990782 protein tyrosine kinase binding
GO:1990869 cellular response to chemokine

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000980 SH2 domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR015012 Phenylalanine zipperDomainDomain
IPR030522 SH2B adapter protein 3FamilyFamily
IPR030523 SH2B adapter proteinFamilyFamily
IPR035059 SH2B3, SH2 domainDomainDomain
IPR036290 Phenylalanine zipper superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB06589 PazopanibDrugbanksmall molecule