Entity Details

Primary name CARD8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9Y2G2
EntryNameCARD8_HUMAN
FullNameCaspase recruitment domain-containing protein 8
TaxID9606
Evidenceevidence at protein level
Length537
SequenceStatuscomplete
DateCreated2001-06-20
DateModified2021-06-02

Ontological Relatives

GenesCARD8

GO terms

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GOName
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032089 NACHT domain binding
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032991 protein-containing complex
GO:0042803 protein homodimerization activity
GO:0042981 regulation of apoptotic process
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0050700 CARD domain binding
GO:0061702 inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097340 inhibition of cysteine-type endopeptidase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Inflammasome
Nucleus

Domains

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DomainNameCategoryType
IPR001315 CARD domainDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR025307 FIIND domainDomainDomain

Diseases

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