Entity Details

Primary name OPA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60313
EntryNameOPA1_HUMAN
FullNameDynamin-like 120 kDa protein, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length960
SequenceStatuscomplete
DateCreated2001-09-26
DateModified2021-06-02

Ontological Relatives

GenesOPA1

GO terms

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GOName
GO:0000002 mitochondrial genome maintenance
GO:0000266 mitochondrial fission
GO:0000287 magnesium ion binding
GO:0001843 neural tube closure
GO:0003374 dynamin family protein polymerization involved in mitochondrial fission
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0007005 mitochondrion organization
GO:0007007 inner mitochondrial membrane organization
GO:0007601 visual perception
GO:0008017 microtubule binding
GO:0008053 mitochondrial fusion
GO:0010636 positive regulation of mitochondrial fusion
GO:0014042 positive regulation of neuron maturation
GO:0014850 response to muscle activity
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019896 axonal transport of mitochondrion
GO:0019900 kinase binding
GO:0030061 mitochondrial crista
GO:0030425 dendrite
GO:0031314 extrinsic component of mitochondrial inner membrane
GO:0031667 response to nutrient levels
GO:0031966 mitochondrial membrane
GO:0036444 calcium import into the mitochondrion
GO:0043066 negative regulation of apoptotic process
GO:0044877 protein-containing complex binding
GO:0046039 GTP metabolic process
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0048312 intracellular distribution of mitochondria
GO:0051259 protein complex oligomerization
GO:0051602 response to electrical stimulus
GO:0060041 retina development in camera-type eye
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061025 membrane fusion
GO:0070300 phosphatidic acid binding
GO:0070584 mitochondrion morphogenesis
GO:0071333 cellular response to glucose stimulus
GO:0071456 cellular response to hypoxia
GO:0090102 cochlea development
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0090398 cellular senescence
GO:0097749 membrane tubulation
GO:1900006 positive regulation of dendrite development
GO:1901612 cardiolipin binding
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:1904115 axon cytoplasm
GO:1904643 response to curcumin
GO:1905232 cellular response to L-glutamate

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane
Mitochondrion intermembrane space
Mitochondrion membrane

Domains

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DomainNameCategoryType
IPR001401 Dynamin, GTPase domainDomainDomain
IPR022812 DynaminFamilyFamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR030381 Dynamin-type guanine nucleotide-binding (G) domainDomainDomain
IPR033047 Dynamin-like 120kDa protein, mitochondrialFamilyFamily

Diseases

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