Entity Details

Primary name JAK2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60674
EntryNameJAK2_HUMAN
FullNameTyrosine-protein kinase JAK2
TaxID9606
Evidenceevidence at protein level
Length1132
SequenceStatuscomplete
DateCreated1998-12-15
DateModified2021-06-02

Ontological Relatives

GenesJAK2

GO terms

Show/Hide Table
GOName
GO:0000165 MAPK cascade
GO:0000186 obsolete activation of MAPKK activity
GO:0000791 euchromatin
GO:0001774 microglial cell activation
GO:0002250 adaptive immune response
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005131 growth hormone receptor binding
GO:0005143 interleukin-12 receptor binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0005925 focal adhesion
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007165 signal transduction
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007259 receptor signaling pathway via JAK-STAT
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007498 mesoderm development
GO:0007596 blood coagulation
GO:0008022 protein C-terminus binding
GO:0008285 negative regulation of cell population proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0020037 heme binding
GO:0022408 negative regulation of cell-cell adhesion
GO:0030041 actin filament polymerization
GO:0030154 cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0031103 axon regeneration
GO:0031702 type 1 angiotensin receptor binding
GO:0031904 endosome lumen
GO:0031959 mineralocorticoid receptor signaling pathway
GO:0032024 positive regulation of insulin secretion
GO:0032496 response to lipopolysaccharide
GO:0032516 positive regulation of phosphoprotein phosphatase activity
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033130 acetylcholine receptor binding
GO:0033194 response to hydroperoxide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0034612 response to tumor necrosis factor
GO:0035401 histone kinase activity (H3-Y41 specific)
GO:0035409 histone H3-Y41 phosphorylation
GO:0035556 intracellular signal transduction
GO:0035722 interleukin-12-mediated signaling pathway
GO:0038155 interleukin-23-mediated signaling pathway
GO:0042169 SH2 domain binding
GO:0042307 positive regulation of protein import into nucleus
GO:0042393 histone binding
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042802 identical protein binding
GO:0042976 activation of Janus kinase activity
GO:0042981 regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043392 negative regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0043560 insulin receptor substrate binding
GO:0045121 membrane raft
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045597 positive regulation of cell differentiation
GO:0045822 negative regulation of heart contraction
GO:0046425 regulation of receptor signaling pathway via JAK-STAT
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046677 response to antibiotic
GO:0046777 protein autophosphorylation
GO:0046872 metal ion binding
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050804 modulation of chemical synaptic transmission
GO:0050867 positive regulation of cell activation
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051428 peptide hormone receptor binding
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0060334 regulation of interferon-gamma-mediated signaling pathway
GO:0060391 positive regulation of SMAD protein signal transduction
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0060399 positive regulation of growth hormone receptor signaling pathway
GO:0061180 mammary gland epithelium development
GO:0070102 interleukin-6-mediated signaling pathway
GO:0070106 interleukin-27-mediated signaling pathway
GO:0070671 response to interleukin-12
GO:0070757 interleukin-35-mediated signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0098794 postsynapse
GO:0098978 glutamatergic synapse
GO:0099527 postsynapse to nucleus signaling pathway
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:2000273 positive regulation of signaling receptor activity

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Endomembrane system
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR000299 FERM domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR019749 Band 4.1 domainDomainDomain
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR020693 Tyrosine-protein kinase, non-receptor Jak2FamilyFamily
IPR035588 Janus kinase 2, pseudokinase domainDomainDomain
IPR035589 Janus kinase 2, catalytic domainDomainDomain
IPR035860 Tyrosine-protein kinase JAK2, SH2 domainDomainDomain
IPR035963 FERM superfamily, second domainFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily
IPR037838 JAK2, FERM domain C-lobeDomainDomain
IPR041046 JAK, FERM F2 lobe domainDomainDomain
IPR041155 FERM F1 lobe ubiquitin-like domainDomainDomain
IPR041381 Jak1, pleckstrin homology-like domainDomainDomain

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB04716 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-oneDrugbanksmall molecule
DB05243 XL019Drugbanksmall molecule
DB07161 5-phenyl-1H-indazol-3-amineDrugbanksmall molecule
DB07162 4-(3-amino-1H-indazol-5-yl)-N-tert-butylbenzenesulfonamideDrugbanksmall molecule
DB08067 4-[(2-{4-[(CYCLOPROPYLCARBAMOYL)AMINO]-1H-PYRAZOL-3-YL}-1H-BENZIMIDAZOL-6-YL)METHYL]MORPHOLIN-4-IUMDrugbanksmall molecule
DB08877 RuxolitinibDrugbanksmall molecule
DB08895 TofacitinibDrugbanksmall molecule
DB11817 BaricitinibDrugbanksmall molecule
DB11986 EntrectinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB12500 FedratinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule
DB15822 PralsetinibDrugbanksmall molecule

Interactions

129 interactions

InteractorPartnerSourcesPublicationsLink
JAK2_HUMANEGFR_HUMANBioGRID, HPRD, MINT10358079 10635327 16273093 23838182 24240702 9363897 details
JAK2_HUMANERBB3_HUMANBioGRID, MINT16273093 details
JAK2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct17474147 7500025 8536716 8950973 details
JAK2_HUMANNCK1_HUMANIntAct17474147 details
JAK2_HUMANP85A_HUMANBioGRID, HPRD, IntAct10026141 16135792 17474147 8702385 details
JAK2_HUMANPLCG1_HUMANBioGRID, IntAct14978237 17474147 details
JAK2_HUMANIL3RB_HUMANBioGRID, HPRD, IntAct, MINT10772872 16437163 18692472 21965659 7527392 7775438 details
JAK2_HUMANPTN1_HUMANBioGRID, HPRD, MINT11694501 11970898 15821101 21806020 details
JAK2_HUMANPTPRJ_HUMANIntAct19167335 details
JAK2_HUMANSOCS3_HUMANBioGRID, HPRD, MINT10421843 10882725 11314018 14517242 15514089 19543316 22342841 24354892 24438103 29752723 9344848 details
JAK2_HUMANSOCS1_HUMANBioGRID, HPRD, MINT10064597 10421843 10455112 11314018 11713228 11971965 14517242 14522994 18508766 19287004 28258213 29674694 29991678 9202126 9344848 details
JAK2_HUMANSH2B1_HUMANBioGRID, HPRD, MINT10757801 12370803 12551917 15316008 15767667 17565041 9343427 details
JAK2_HUMANSH2B2_HUMANBioGRID, HPRD, MINT10374881 10872802 15767667 details
JAK2_HUMANANM5_HUMANBioGRID, HPRD, IntAct10531356 21316606 details
JAK2_HUMANASSY_HUMANBioGRID, IntAct21988832 details
JAK2_HUMANRBMX_HUMANBioGRID, IntAct21988832 details
JAK2_HUMANTRAF6_HUMANBioGRID, IntAct21988832 details
JAK2_HUMANPP1G_HUMANBioGRID, IntAct21382349 details
JAK2_HUMANCDN1B_HUMANBioGRID, I2D21423214 details
JAK2_HUMANSTAT1_HUMANBioGRID, HPRD, MINT10918587 11152457 11294897 11839738 12637327 12817007 14978237 15284024 15322115 19834108 20353823 24255956 7543024 7657660 7690989 details
JAK2_HUMANJAK1_HUMANBioGRID, IntAct26175413 32001089 details
JAK2_HUMANIL5RA_HUMANBioGRID, HPRD, IntAct9516124 details
JAK2_HUMANJAK2_HUMANBioGRID, DIP, HPRD10026141 11593427 11818507 15121872 15143187 15143188 15767667 16609991 17027227 21841788 22820988 24354892 7889566 8041779 8609418 9111318 9516124 details
JAK2_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct10918587 10925297 11294897 11350938 11940572 12244095 12576423 12626508 14551213 15156153 15284024 19834108 23838182 26775640 27351213 30413785 8626374 9211920 details
JAK2_HUMANI12R2_HUMANBioGRID, HPRD10198225 details
JAK2_HUMANEPOR_HUMANBioGRID, HPRD11779507 12441334 14982882 8343951 details
JAK2_HUMANFYN_HUMANBioGRID, HPRD10551884 details
JAK2_HUMANSTA5A_HUMANBioGRID, HPRD11413148 7925280 8617237 9047382 9575217 details
JAK2_HUMANSTA5B_HUMANBioGRID, HPRD12538627 24354892 9047382 9575217 details
JAK2_HUMANDNJA3_HUMANBioGRID, HPRD11679576 details
JAK2_HUMANTEC_HUMANBioGRID, HPRD9178903 9473212 details
JAK2_HUMANVAV_HUMANBioGRID, HPRD7530656 9162069 details
JAK2_HUMANIRS1_HUMANBioGRID, HPRD11208867 12960006 15316008 9492017 details
JAK2_HUMANPTN11_HUMANBioGRID, HPRD7559603 8639815 8912646 8995399 9442080 details
JAK2_HUMANTNR1A_HUMANBioGRID, HPRD18606683 9510175 details
JAK2_HUMANLYN_HUMANBioGRID, HPRD9573010 details
JAK2_HUMANRAF1_HUMANBioGRID, HPRD10205168 11134016 8876196 9689060 details
JAK2_HUMANINGR2_HUMANBioGRID, HPRD7514165 7673114 details
JAK2_HUMANSHC1_HUMANBioGRID, HPRD7535773 9126968 details
JAK2_HUMANTUB_HUMANBioGRID, HPRD10455176 details
JAK2_HUMANSTAM1_HUMANBioGRID, HPRD9133424 details
JAK2_HUMANNEMO_HUMANBioGRID20098747 details
JAK2_HUMANGTF2I_HUMANBioGRID, HPRD11313464 11373296 11934902 9012831 9837922 details
JAK2_HUMANH31T_HUMANBioGRID19783980 details
JAK2_HUMANM3K5_HUMANBioGRID19287004 details
JAK2_HUMANEZH2_HUMANBioGRID24469040 details
JAK2_HUMANARL11_HUMANBioGRID27229929 details
JAK2_HUMANHSFY1_HUMANBioGRID27229929 details
JAK2_HUMANCBL_HUMANBioGRID28676638 details
JAK2_HUMANBRCA1_HUMANBioGRID, HPRD, MINT11163768 details
JAK2_HUMANLEPR_HUMANHPRD, IntAct11585385 8608603 details
JAK2_HUMANG3BP1_HUMANMINT15743820 details
JAK2_HUMANTPOR_HUMANBioGRID, HPRD, IntAct10224114 10918061 10979953 24931576 30755420 7534285 details
JAK2_HUMANTYK2_HUMANIntAct26175413 details
JAK2_HUMANROCK2_HUMANIntAct30413785 details
JAK2_HUMANSTRA6_HUMANIntAct21368206 details
JAK2_HUMANPPIA_HUMANBioGRID, HPRD12668872 details
JAK2_HUMANCXCR4_HUMANBioGRID, HPRD10506573 details
JAK2_HUMANHSP7C_HUMANBioGRID, HPRD11679576 details
JAK2_HUMANPTN12_HUMANBioGRID, HPRD11731619 details
JAK2_HUMANFAK1_HUMANBioGRID10925297 9553131 details
JAK2_HUMANGHR_HUMANBioGRID, HPRD10502458 21347402 24280222 7540178 8063815 details
JAK2_HUMANSHPS1_HUMANBioGRID, HPRD10842184 details
JAK2_HUMANFAK2_HUMANBioGRID, HPRD11818507 details
JAK2_HUMANPTN6_HUMANBioGRID, HPRD10772872 8943354 details
JAK2_HUMAN5HT2A_HUMANBioGRID, HPRD9169451 details
JAK2_HUMANERBB2_HUMANBioGRID, HPRD11940572 details
JAK2_HUMANELP2_HUMANBioGRID, HPRD10954736 details
JAK2_HUMANKIT_HUMANBioGRID, HPRD7527392 8611693 9355737 details
JAK2_HUMAN2AAB_HUMANBioGRID, HPRD11440634 details
JAK2_HUMANINGR1_HUMANBioGRID, HPRD11438544 21689637 7499845 7673114 details
JAK2_HUMANCCR5_HUMANBioGRID, HPRD11278738 11591716 details
JAK2_HUMANPRLR_HUMANBioGRID, HPRD10772872 20962278 9202403 details
JAK2_HUMANIL6RB_HUMANBioGRID9388212 details
JAK2_HUMANGRB10_HUMANBioGRID, HPRD9632636 details
JAK2_HUMANTSHR_HUMANBioGRID, HPRD10809230 details
JAK2_HUMANINSR_HUMANBioGRID, HPRD12456798 8912646 details
JAK2_HUMANSTAM2_HUMANBioGRID, HPRD10899310 details
JAK2_HUMANIL2RB_HUMANBioGRID9553136 details
JAK2_HUMANCTLA4_HUMANBioGRID, HPRD10842319 details
JAK2_HUMANALK_HUMANBioGRID14968112 details
JAK2_HUMANFGFR1_HUMANBioGRID20388777 details
JAK2_HUMANHS90A_HUMANBioGRID20353823 details
JAK2_HUMANHS90B_HUMANBioGRID20353823 details
JAK2_HUMANASB2_HUMANBioGRID21119685 details
JAK2_HUMANSKP2_HUMANBioGRID21119685 details
JAK2_HUMANH32_HUMANBioGRID21689637 details
JAK2_HUMANVHL_HUMANBioGRID21685897 32356150 details
JAK2_HUMANAGTR1_HUMANBioGRID, HPRD11152457 7746328 details
JAK2_HUMANPTAFR_HUMANBioGRID14500680 details
JAK2_HUMANIL4RA_HUMANBioGRID, HPRD8609418 details
JAK2_HUMANIL2RG_HUMANBioGRID8041779 details
JAK2_HUMANCALM1_HUMANBioGRID12626508 details
JAK2_HUMANCALM2_HUMANBioGRID12626508 details
JAK2_HUMANCALM3_HUMANBioGRID12626508 details
JAK2_HUMANJAK3_HUMANBioGRID, HPRD11585385 12207328 details
JAK2_HUMANHES1_HUMANBioGRID, HPRD15156153 details
JAK2_HUMANHES5_HUMANBioGRID, HPRD15156153 details
JAK2_HUMANDTX3L_HUMANBioGRID24886089 details
JAK2_HUMANHDAC6_HUMANBioGRID26775640 details
JAK2_HUMANGOLP3_HUMANBioGRID29713848 details
JAK2_HUMANIGF1R_HUMANBioGRID, HPRD10747872 15044591 9492017 details
JAK2_HUMANPARP9_HUMANBioGRID23487038 details
JAK2_HUMANLNX1_HUMANBioGRID30634502 details
JAK2_HUMANLDOC1_HUMANBioGRID30634502 details
JAK2_HUMANPKD1_HUMANHPRD12007403 details
JAK2_HUMANSTAT2_HUMANHPRD7746328 details
JAK2_HUMANFES_HUMANHPRD8631962 details
JAK2_HUMANCRLF2_HUMANHPRD10872831 details
JAK2_HUMANPLCG2_HUMANHPRD14978237 details
JAK2_HUMANIRS2_HUMANHPRD12960006 details
JAK2_HUMANIKBA_HUMANHPRD11493922 details
JAK2_HUMANPGFRB_HUMANHPRD8657151 9484840 details
JAK2_HUMANIL3RA_HUMANHPRD15988755 details
JAK2_HUMANRON_HUMANHPRD14982882 details
JAK2_HUMANPP2AA_HUMANHPRD11440634 details
JAK2_HUMANCSF3R_HUMANHPRD7775438 details
JAK2_HUMANBCR_HUMANHPRD12023981 12370803 details
JAK2_HUMANPTPRC_HUMANHPRD11201744 details
JAK2_HUMANMK_HUMANHPRD9452495 details
JAK2_HUMANYES_HUMANHPRD8702385 details
JAK2_HUMANABL1_HUMANHPRD11593427 15143187 9111318 details
JAK2_HUMANTERA_HUMANHPRD11087817 details
JAK2_HUMANCCR2_HUMANHPRD9670957 details
JAK2_HUMAN2A5A_HUMANHPRD8702385 details
JAK2_HUMANOSMR_HUMANHPRD10586060 details
JAK2_HUMANSTAP2_HUMANHPRD12540842 details
JAK2_HUMANIL23R_HUMANHPRD12023369 details
JAK2_HUMANUBS3B_HUMANHPRD12370296 details