Entity Details

Primary name MITF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75030
EntryNameMITF_HUMAN
FullNameMicrophthalmia-associated transcription factor
TaxID9606
Evidenceevidence at protein level
Length526
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesMITF

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0010628 positive regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0030318 melanocyte differentiation
GO:0030336 negative regulation of cell migration
GO:0032991 protein-containing complex
GO:0042127 regulation of cell population proliferation
GO:0043010 camera-type eye development
GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process
GO:0045165 cell fate commitment
GO:0045670 regulation of osteoclast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046849 bone remodeling
GO:0046983 protein dimerization activity
GO:0065003 protein-containing complex assembly
GO:0070888 E-box binding
GO:2000144 positive regulation of DNA-templated transcription, initiation
GO:2001141 regulation of RNA biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR021802 MiT/TFE transcription factors, C-terminalDomainDomain
IPR030532 Microphthalmia-associated transcription factorFamilyFamily
IPR031867 MiT/TFE transcription factors, N-terminalDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
MITF_HUMANHXK3_HUMANBioGRID, IntAct21988832 details
MITF_HUMANCHIP_HUMANBioGRID, IntAct21988832 details
MITF_HUMANEBP_HUMANBioGRID, IntAct21988832 details
MITF_HUMANADRB2_HUMANBioGRID, MINT28298427 details
MITF_HUMANLEF1_HUMANBioGRID, HPRD12032083 12048204 details
MITF_HUMANPIAS3_HUMANBioGRID, HPRD11709556 16029420 details
MITF_HUMANPATZ1_HUMANBioGRID, HPRD11751862 details
MITF_HUMANUBC9_HUMANBioGRID, HPRD10694430 16029420 details
MITF_HUMANSPI1_HUMANBioGRID, HPRD9918847 details
MITF_HUMANPAX6_HUMANBioGRID, HPRD11350962 details
MITF_HUMANPIAS1_HUMANBioGRID16029420 details
MITF_HUMANPIAS2_HUMANBioGRID16029420 details
MITF_HUMANPSDE_HUMANBioGRID20058232 details
MITF_HUMANMARK3_HUMANBioGRID20058232 details
MITF_HUMANHINT1_HUMANBioGRID22647378 details
MITF_HUMANA4_HUMANBioGRID21832049 details
MITF_HUMANFBX7_HUMANBioGRID27503909 details
MITF_HUMAN1433Z_HUMANMINT16822840 details
MITF_HUMANTFEB_HUMANBioGRID, HPRD, IntAct26496610 28514442 9806910 details
MITF_HUMANTFE3_HUMANBioGRID, HPRD, IntAct11818452 11930005 28514442 details
MITF_HUMANSUMO1_HUMANBioGRID, DIP, HPRD10694430 16029420 22012259 details
MITF_HUMANFOS_HUMANBioGRID, HPRD9918847 details
MITF_HUMANTFEC_HUMANBioGRID, HPRD11818452 details
MITF_HUMANEPAS1_HUMANBioGRID23275444 details
MITF_HUMANEP300_HUMANBioGRID, HPRD9660747 details
MITF_HUMANUCHL1_HUMANBioGRID28392346 details
MITF_HUMANOTX2_HUMANHPRD12663655 details
MITF_HUMANMK01_HUMANHPRD9440696 details
MITF_HUMANMK14_HUMANHPRD11792706 details
MITF_HUMANKS6A1_HUMANHPRD10673502 details
MITF_HUMANCTNB1_HUMANHPRD15729346 details
MITF_HUMANPAX3_HUMANHPRD15729346 details
MITF_HUMANGSK3B_HUMANHPRD10587587 details