Entity Details

Primary name ULK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75385
EntryNameULK1_HUMAN
FullNameSerine/threonine-protein kinase ULK1
TaxID9606
Evidenceevidence at protein level
Length1050
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesULK1

GO terms

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GOName
GO:0000045 autophagosome assembly
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005741 mitochondrial outer membrane
GO:0005776 autophagosome
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0006914 autophagy
GO:0007165 signal transduction
GO:0008104 protein localization
GO:0010508 positive regulation of autophagy
GO:0016236 macroautophagy
GO:0016241 regulation of macroautophagy
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0030424 axon
GO:0031102 neuron projection regeneration
GO:0031175 neuron projection development
GO:0031267 small GTPase binding
GO:0031333 negative regulation of protein-containing complex assembly
GO:0031669 cellular response to nutrient levels
GO:0034045 phagophore assembly site membrane
GO:0042594 response to starvation
GO:0042802 identical protein binding
GO:0044877 protein-containing complex binding
GO:0046777 protein autophosphorylation
GO:0048675 axon extension
GO:0051020 GTPase binding
GO:0055037 recycling endosome
GO:0075044 positive regulation by symbiont of host autophagy
GO:0097629 extrinsic component of omegasome membrane
GO:0097632 extrinsic component of phagophore assembly site membrane
GO:0097635 extrinsic component of autophagosome membrane
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1990316 Atg1/ULK1 kinase complex
GO:2000786 positive regulation of autophagosome assembly

Subcellular Location

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Subcellular Location
Cytoplasm
Preautophagosomal structure

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR016237 Serine/threonine-protein kinase, Ulk1/Ulk2FamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR022708 Serine/threonine-protein kinase, C-terminalDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

85 interactions

InteractorPartnerSourcesPublicationsLink
ULK1_HUMANOCLN_HUMANBioGRID, MINT16616143 details
ULK1_HUMANGBRAP_HUMANBioGRID, HPRD, IntAct11146101 17353931 20562859 23043107 25126726 28253953 details
ULK1_HUMANATG13_HUMANBioGRID, DIP, IntAct, MINT18936157 19597335 20562859 21460630 21460634 23392225 23524951 25126726 25686248 26018823 27203176 27617292 29196462 30853401 32543267 33422265 33450483 details
ULK1_HUMANGBRL1_HUMANBioGRID, IntAct20562859 23043107 28253953 details
ULK1_HUMANGBRL2_HUMANBioGRID, HPRD, IntAct11146101 20562859 23043107 28253953 details
ULK1_HUMANMLP3B_HUMANBioGRID, DIP, IntAct20562859 23043107 24290141 28253953 30907226 details
ULK1_HUMANMLP3C_HUMANBioGRID, DIP, IntAct20562859 23043107 24290141 28253953 details
ULK1_HUMANULK1_HUMANBioGRID, DIP, IntAct20562859 23524951 details
ULK1_HUMANAAPK1_HUMANBioGRID, DIP, IntAct20562859 21072212 21460634 25686248 details
ULK1_HUMANNRBF2_HUMANBioGRID, IntAct20562859 28059666 details
ULK1_HUMANPP1A_HUMANBioGRID, IntAct22321011 details
ULK1_HUMANTBC14_HUMANbhf-ucl22613832 details
ULK1_HUMANATG9A_HUMANbhf-ucl, BioGRID22613832 27934868 details
ULK1_HUMANSESN2_HUMANBioGRID, MINT25040165 29330382 details
ULK1_HUMANSQSTM_HUMANBioGRID, DIP17389358 25040165 25723488 30335599 30907226 details
ULK1_HUMANAMRA1_HUMANBioGRID, DIP20921139 23524951 25438055 details
ULK1_HUMANMLP3A_HUMANBioGRID, DIP23043107 24290141 28069524 28253953 details
ULK1_HUMANRPTOR_HUMANBioGRID, DIP21460630 21460634 21795849 25686248 details
ULK1_HUMANSMCR8_HUMANBioGRID, MINT27103069 30669939 details
ULK1_HUMANSYGP1_HUMANBioGRID, HPRD15014045 details
ULK1_HUMANSDCB1_HUMANBioGRID, HPRD15014045 details
ULK1_HUMANMBP_HUMANBioGRID18936157 23524951 details
ULK1_HUMANBECN1_HUMANBioGRID21241894 25891078 27046250 27693506 28059666 28518135 29251248 29313410 29604308 30335599 details
ULK1_HUMANEXOC8_HUMANBioGRID21241894 details
ULK1_HUMANMUL1_HUMANBioGRID26018823 details
ULK1_HUMANMEFV_HUMANBioGRID26347139 details
ULK1_HUMANFLCN_HUMANBioGRID25126726 details
ULK1_HUMANNED4L_HUMANBioGRID27932573 31959741 details
ULK1_HUMANTRI16_HUMANBioGRID27693506 details
ULK1_HUMANUBP20_HUMANBioGRID29487085 details
ULK1_HUMANBAKOR_HUMANBioGRID27046250 27938392 28059666 28069524 details
ULK1_HUMANMK14_HUMANBioGRID29196462 details
ULK1_HUMANUBC_HUMANBioGRID31123703 details
ULK1_HUMANSTABP_HUMANBioGRID32453962 details
ULK1_HUMANRBCC1_HUMANBioGRID, DIP, IntAct, MINT20562859 21460634 23392225 23524951 25686248 30853401 32543267 33422265 details
ULK1_HUMANCDC37_HUMANBioGRID, IntAct20562859 21855797 details
ULK1_HUMANAAPK2_HUMANBioGRID, IntAct20562859 21072212 details
ULK1_HUMANFEZ1_HUMANMINT22354037 details
ULK1_HUMANA16L1_HUMANBioGRID, MINT23262492 23392225 27875067 29634390 details
ULK1_HUMANATGA1_HUMANBioGRID, DIP, IntAct, MINT19597335 21460634 23392225 25686248 details
ULK1_HUMANTBCD5_HUMANMINT24603492 details
ULK1_HUMANPCM1_HUMANIntAct28712572 details
ULK1_HUMANNTRK1_HUMANDIP17389358 details
ULK1_HUMANTRAF6_HUMANBioGRID, DIP23524951 details
ULK1_HUMANMTOR_HUMANBioGRID, DIP21460630 23524951 25686248 29321306 details
ULK1_HUMANHD_HUMANBioGRID, DIP25686248 details
ULK1_HUMANAAKB1_HUMANBioGRID, DIP, IntAct21072212 25686248 details
ULK1_HUMANCI072_HUMANBioGRID, IntAct, MINT, UniProt27103069 27334615 27617292 29950492 30669939 details
ULK1_HUMANPDPK1_HUMANMINT26593251 details
ULK1_HUMANDISC1_HUMANIntAct31413325 details
ULK1_HUMANLST8_HUMANBioGRID21460630 details
ULK1_HUMANRALB_HUMANBioGRID21241894 details
ULK1_HUMANEXOC2_HUMANBioGRID21241894 details
ULK1_HUMANDAPK3_HUMANBioGRID21169990 details
ULK1_HUMANRAB1A_HUMANBioGRID23716696 details
ULK1_HUMANNLRP3_HUMANBioGRID26347139 details
ULK1_HUMANRO52_HUMANBioGRID26347139 details
ULK1_HUMANIRF3_HUMANBioGRID26347139 details
ULK1_HUMANIRGM_HUMANBioGRID25891078 details
ULK1_HUMANBIRC2_HUMANBioGRID27693792 details
ULK1_HUMANNEDD4_HUMANBioGRID29251248 details
ULK1_HUMANPARP1_HUMANBioGRID28796254 details
ULK1_HUMANH2AX_HUMANBioGRID28796254 details
ULK1_HUMANRAD51_HUMANBioGRID28796254 details
ULK1_HUMANHS90A_HUMANBioGRID21855797 details
ULK1_HUMANPTC1_HUMANBioGRID29453315 details
ULK1_HUMANBAD_HUMANBioGRID28518135 details
ULK1_HUMANLYN_HUMANBioGRID27742708 details
ULK1_HUMANHDAC6_HUMANBioGRID30335599 details
ULK1_HUMANWDR48_HUMANBioGRID30335599 details
ULK1_HUMANUBP1_HUMANBioGRID30335599 details
ULK1_HUMANKEAP1_HUMANBioGRID30907226 details
ULK1_HUMANPINK1_HUMANBioGRID30907226 details
ULK1_HUMANTBK1_HUMANBioGRID28716898 details
ULK1_HUMANTRI32_HUMANBioGRID31123703 details
ULK1_HUMANSC16A_HUMANBioGRID27203176 details
ULK1_HUMANCACO2_HUMANBioGRID30853401 details
ULK1_HUMANOPTN_HUMANBioGRID31723608 details
ULK1_HUMANSTYK1_HUMANBioGRID31696776 details
ULK1_HUMANB2L13_HUMANBioGRID30625316 details
ULK1_HUMANUBP19_HUMANBioGRID32453962 details
ULK1_HUMANCYLD_HUMANBioGRID32453962 details
ULK1_HUMANOTU7B_HUMANBioGRID32453962 details
ULK1_HUMANSTALP_HUMANBioGRID32453962 details
ULK1_HUMANJOS1_HUMANBioGRID32453962 details