Entity Details

Primary name ERN1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75460
EntryNameERN1_HUMAN
FullNameSerine/threonine-protein kinase/endoribonuclease IRE1
TaxID9606
Evidenceevidence at protein level
Length977
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesERN1

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0001935 endothelial cell proliferation
GO:0004521 endoribonuclease activity
GO:0004674 protein serine/threonine kinase activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005524 ATP binding
GO:0005637 nuclear inner membrane
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0006379 mRNA cleavage
GO:0006402 mRNA catabolic process
GO:0006468 protein phosphorylation
GO:0007257 obsolete activation of JUN kinase activity
GO:0016241 regulation of macroautophagy
GO:0019899 enzyme binding
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030544 Hsp70 protein binding
GO:0033120 positive regulation of RNA splicing
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036289 peptidyl-serine autophosphorylation
GO:0036498 IRE1-mediated unfolded protein response
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046777 protein autophosphorylation
GO:0051082 unfolded protein binding
GO:0051879 Hsp90 protein binding
GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070301 cellular response to hydrogen peroxide
GO:0071333 cellular response to glucose stimulus
GO:0098787 mRNA cleavage involved in mRNA processing
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response
GO:1901142 insulin metabolic process
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1990332 Ire1 complex
GO:1990579 peptidyl-serine trans-autophosphorylation
GO:1990597 AIP1-IRE1 complex
GO:1990604 IRE1-TRAF2-ASK1 complex
GO:1990630 IRE1-RACK1-PP2A complex

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR010513 KEN domainDomainDomain
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamilyFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR018391 Pyrrolo-quinoline quinone beta-propeller repeatRepeatRepeat
IPR038357 KEN domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07382 N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamineDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

62 interactions

InteractorPartnerSourcesPublicationsLink
ERN1_HUMANERN1_HUMANBioGRID, DIP, HPRD, IntAct, MINT12637535 16973740 20798350 21317875 details
ERN1_HUMANBAX_HUMANHPRD, IntAct16645094 details
ERN1_HUMANTAOK3_HUMANBioGRID, HPRD, IntAct11278723 details
ERN1_HUMANSRPK2_HUMANBioGRID, IntAct23602568 details
ERN1_HUMANBIP_HUMANBioGRID, DIP, HPRD, IntAct12637535 21118962 26551274 27238082 32149426 details
ERN1_HUMANZN829_HUMANIntAct32814053 details
ERN1_HUMANPELI3_HUMANIntAct32814053 details
ERN1_HUMANSPAS1_HUMANIntAct32814053 details
ERN1_HUMANADAL_HUMANIntAct32814053 details
ERN1_HUMANKAD8_HUMANIntAct32814053 details
ERN1_HUMANZN341_HUMANIntAct32814053 details
ERN1_HUMANTMTC1_HUMANIntAct32814053 details
ERN1_HUMANPKHS1_HUMANIntAct32814053 details
ERN1_HUMANOTU7B_HUMANIntAct32814053 details
ERN1_HUMANCBWD1_HUMANIntAct32814053 details
ERN1_HUMANASIC4_HUMANIntAct32814053 details
ERN1_HUMANWBP1L_HUMANIntAct32814053 details
ERN1_HUMANAR6P4_HUMANIntAct32814053 details
ERN1_HUMANCD209_HUMANIntAct32814053 details
ERN1_HUMANPKHG4_HUMANIntAct32814053 details
ERN1_HUMANDPOA2_HUMANIntAct32814053 details
ERN1_HUMANLAT2_HUMANIntAct32814053 details
ERN1_HUMANLAR4B_HUMANIntAct32814053 details
ERN1_HUMANBAHD1_HUMANIntAct32814053 details
ERN1_HUMANSOCS6_HUMANIntAct32814053 details
ERN1_HUMANDNJA3_HUMANIntAct32814053 details
ERN1_HUMANASH2L_HUMANIntAct32814053 details
ERN1_HUMANDPF1_HUMANIntAct32814053 details
ERN1_HUMANUBE2A_HUMANIntAct32814053 details
ERN1_HUMANPER1_HUMANIntAct32814053 details
ERN1_HUMANTF2AA_HUMANIntAct32814053 details
ERN1_HUMANGABP1_HUMANIntAct32814053 details
ERN1_HUMANCDN1A_HUMANIntAct32814053 details
ERN1_HUMANINCA1_HUMANIntAct32814053 details
ERN1_HUMANHS90A_HUMANBioGRID, HPRD12446770 details
ERN1_HUMANCSN5_HUMANBioGRID, HPRD15234121 17951406 details
ERN1_HUMANUBP14_HUMANBioGRID19135427 24951540 details
ERN1_HUMANCHIP_HUMANBioGRID25225294 details
ERN1_HUMANNMI_HUMANBioGRID24936061 details
ERN1_HUMANMARH5_HUMANBioGRID31368599 details
ERN1_HUMANPDIA1_HUMANBioGRID32149426 details
ERN1_HUMANSYVN1_HUMANBioGRID, DIP, HPRD, MINT18369366 19135427 26254280 26551274 details
ERN1_HUMANUBC_HUMANMINT18369366 details
ERN1_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct10650002 11278723 12843613 25225294 25241761 25797626 details
ERN1_HUMANM3K5_HUMANBioGRID, HPRD, IntAct12050113 25241761 25797626 details
ERN1_HUMANYIPF5_HUMANHPIDb25742138 details
ERN1_HUMANOS9_HUMANDIP26551274 details
ERN1_HUMANSE1L1_HUMANBioGRID, DIP19135427 26551274 details
ERN1_HUMANPSN1_HUMANBioGRID, HPRD10587643 details
ERN1_HUMANDERL1_HUMANBioGRID19135427 details
ERN1_HUMANDERL3_HUMANBioGRID19135427 details
ERN1_HUMANTRAF6_HUMANBioGRID23942232 details
ERN1_HUMANRNF13_HUMANBioGRID23378536 details
ERN1_HUMANP53_HUMANBioGRID26254280 details
ERN1_HUMANRIPK1_HUMANBioGRID25476903 details
ERN1_HUMANSC61B_HUMANBioGRID28504640 details
ERN1_HUMANS61A1_HUMANBioGRID28504640 details
ERN1_HUMANSEC63_HUMANBioGRID28504640 details
ERN1_HUMANB2L11_HUMANBioGRID31368599 details
ERN1_HUMANPDIA6_HUMANBioGRID32149426 details
ERN1_HUMANBAK_HUMANHPRD16645094 details
ERN1_HUMANTNR1A_HUMANHPRD16680093 details