Entity Details

Primary name SPDEF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95238
EntryNameSPDEF_HUMAN
FullNameSAM pointed domain-containing Ets transcription factor
TaxID9606
Evidenceevidence at protein level
Length335
SequenceStatuscomplete
DateCreated2006-02-21
DateModified2021-06-02

Ontological Relatives

GenesSPDEF

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005634 nucleus
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007275 multicellular organism development
GO:0010454 negative regulation of cell fate commitment
GO:0010455 positive regulation of cell fate commitment
GO:0030154 cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060480 lung goblet cell differentiation
GO:0060576 intestinal epithelial cell development
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR000418 Ets domainDomainDomain
IPR003118 Pointed domainDomainDomain
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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