Entity Details

Primary name AACT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01011
EntryNameAACT_HUMAN
FullNameAlpha-1-antichymotrypsin
TaxID9606
Evidenceevidence at protein level
Length423
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesSERPINA3

GO terms

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GOName
GO:0002576 platelet degranulation
GO:0003677 DNA binding
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0006953 acute-phase response
GO:0006954 inflammatory response
GO:0010951 negative regulation of endopeptidase activity
GO:0019216 regulation of lipid metabolic process
GO:0030277 maintenance of gastrointestinal epithelium
GO:0031093 platelet alpha granule lumen
GO:0034774 secretory granule lumen
GO:0035578 azurophil granule lumen
GO:0043312 neutrophil degranulation
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0072562 blood microparticle

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000215 Serpin familyFamilyFamily
IPR023795 Serpin, conserved siteSiteConserved site
IPR023796 Serpin domainDomainDomain
IPR036186 Serpin superfamilyFamilyHomologous superfamily
IPR042178 Serpin superfamily, domain 1FamilyHomologous superfamily
IPR042185 Serpin superfamily, domain 2FamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01593 ZincDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

37 interactions

InteractorPartnerSourcesPublicationsLink
AACT_HUMANDNJC1_HUMANBioGRID, HPRD, IntAct14668352 details
AACT_HUMANLMNB1_HUMANBioGRID, IntAct21988832 details
AACT_HUMANADH1B_HUMANBioGRID, IntAct21988832 details
AACT_HUMANNFKB1_HUMANBioGRID, IntAct21988832 details
AACT_HUMANRPA12_HUMANBioGRID, IntAct21988832 details
AACT_HUMANMRP5_HUMANBioGRID, IntAct21988832 details
AACT_HUMANLAMC3_HUMANBioGRID, IntAct21988832 details
AACT_HUMANSGCD_HUMANBioGRID, IntAct23414517 details
AACT_HUMANVP33A_HUMANIntAct32814053 details
AACT_HUMANVPS29_HUMANIntAct32814053 details
AACT_HUMANCHIP_HUMANIntAct32814053 details
AACT_HUMANCASP6_HUMANIntAct32814053 details
AACT_HUMANLAMP2_HUMANIntAct32814053 details
AACT_HUMANSHLB1_HUMANIntAct32814053 details
AACT_HUMANA4_HUMANHPRD, IntAct10048303 2190106 32814053 details
AACT_HUMANELNE_HUMANBioGRID, HPRD8011628 8718849 details
AACT_HUMANKLK2_HUMANBioGRID, HPRD10209959 9042371 9428387 details
AACT_HUMANKLK13_HUMANBioGRID14687906 details
AACT_HUMANHS90A_HUMANBioGRID31273033 details
AACT_HUMANATS4_HUMANHPRD16099106 details
AACT_HUMANKLK3_HUMANHPRD, IntAct10759471 11317942 22806587 9261179 details
AACT_HUMANVATB1_HUMANBioGRID21674799 details
AACT_HUMANFGF11_HUMANBioGRID28027390 details
AACT_HUMANAACT_HUMANHPRD14668352 details
AACT_HUMANCATG_HUMANHPRD10512690 8849841 9698370 details
AACT_HUMANCTRL_HUMANHPRD8267879 details
AACT_HUMANCTRB1_HUMANHPRD2435303 details
AACT_HUMANCMA1_HUMANHPRD8226889 details
AACT_HUMANMMP1_HUMANHPRD1311327 details
AACT_HUMANCELA1_HUMANHPRD2456771 7759598 details
AACT_HUMANHGFL_HUMANHPRD11274154 details
AACT_HUMANERBB2_HUMANHPRD10829039 details
AACT_HUMANFA5_HUMANHPRD8216224 details
AACT_HUMANDPOLA_HUMANHPRD3490907 details
AACT_HUMANCTRC_HUMANHPRD8718849 9635374 details
AACT_HUMANHXB1_HUMANHPRD123121 details
AACT_HUMANKLK4_HUMANHPRD11735417 details