Entity Details

Primary name NGF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01138
EntryNameNGF_HUMAN
FullNameBeta-nerve growth factor
TaxID9606
Evidenceevidence at protein level
Length241
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesNGF

GO terms

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GOName
GO:0000186 obsolete activation of MAPKK activity
GO:0004857 enzyme inhibitor activity
GO:0005163 nerve growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005796 Golgi lumen
GO:0005829 cytosol
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007422 peripheral nervous system development
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0008083 growth factor activity
GO:0008191 metalloendopeptidase inhibitor activity
GO:0008285 negative regulation of cell population proliferation
GO:0008289 lipid binding
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010628 positive regulation of gene expression
GO:0021675 nerve development
GO:0030424 axon
GO:0030425 dendrite
GO:0031904 endosome lumen
GO:0032455 nerve growth factor processing
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0038177 death receptor agonist activity
GO:0038180 nerve growth factor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048672 positive regulation of collateral sprouting
GO:0048812 neuron projection morphogenesis
GO:0050772 positive regulation of axonogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0051402 neuron apoptotic process

Subcellular Location

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Subcellular Location
Endosome lumen
Secreted

Domains

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DomainNameCategoryType
IPR002072 Nerve growth factor-relatedDomainDomain
IPR019846 Nerve growth factor conserved siteSiteConserved site
IPR020408 Nerve growth factor-likeFamilyFamily
IPR020425 Nerve growth factor, beta subunitFamilyFamily
IPR020437 Nerve growth factor, beta subunit, mammalianFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01407 ClenbuterolDrugbanksmall molecule
DB05892 RI 624Drugbankbiotech
DB09221 PolaprezincDrugbanksmall molecule