Entity Details

Primary name DRA_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP01903
EntryNameDRA_HUMAN
FullNameHLA class II histocompatibility antigen, DR alpha chain
TaxID9606
Evidenceevidence at protein level
Length254
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesHLA-DRA

GO terms

Show/Hide Table
GOName
GO:0043382 positive regulation of memory T cell differentiation
GO:0050852 T cell receptor signaling pathway
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0050890 cognition
GO:0060333 interferon-gamma-mediated signaling pathway
GO:0005765 lysosomal membrane
GO:0042613 MHC class II protein complex
GO:0030658 transport vesicle membrane
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0045622 regulation of T-helper cell differentiation
GO:0000139 Golgi membrane
GO:0002503 peptide antigen assembly with MHC class II protein complex
GO:0030666 endocytic vesicle membrane
GO:0042605 peptide antigen binding
GO:0002250 adaptive immune response
GO:0009986 cell surface
GO:0005887 integral component of plasma membrane
GO:0023026 MHC class II protein complex binding
GO:0005764 lysosome
GO:0031901 early endosome membrane
GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002469 myeloid dendritic cell antigen processing and presentation
GO:0006955 immune response
GO:0070062 extracellular exosome
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0030247 polysaccharide binding
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0031902 late endosome membrane
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0002491 antigen processing and presentation of endogenous peptide antigen via MHC class II
GO:0032395 MHC class II receptor activity
GO:2000516 positive regulation of CD4-positive, alpha-beta T cell activation
GO:0012507 ER to Golgi transport vesicle membrane
GO:0016032 viral process
GO:0042608 T cell receptor binding
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane

Subcellular Location

Show/Hide Table
Subcellular Location
Early endosome membrane
Autolysosome membrane
Lysosome membrane
Cell membrane
Endoplasmic reticulum membrane
Late endosome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001003 MHC class II, alpha chain, N-terminalDomainDomain
IPR003006 Immunoglobulin/major histocompatibility complex, conserved siteSiteConserved site
IPR003597 Immunoglobulin C1-setDomainDomain
IPR007110 Immunoglobulin-like domainDomainDomain
IPR011162 MHC classes I/II-like antigen recognition proteinFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014745 MHC class II, alpha/beta chain, N-terminalFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB05121 1D09C3Drugbankbiotech
DB11294 Coccidioides immitis spheruleDrugbankbiotech