Entity Details

Primary name ANXA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04083
EntryNameANXA1_HUMAN
FullNameAnnexin A1
TaxID9606
Evidenceevidence at protein level
Length346
SequenceStatuscomplete
DateCreated1986-11-01
DateModified2021-06-02

Ontological Relatives

GenesANXA1

GO terms

Show/Hide Table
GOName
GO:0001533 cornified envelope
GO:0001780 neutrophil homeostasis
GO:0001891 phagocytic cup
GO:0002250 adaptive immune response
GO:0002548 monocyte chemotaxis
GO:0002685 regulation of leukocyte migration
GO:0003697 single-stranded DNA binding
GO:0003727 single-stranded RNA binding
GO:0005102 signaling receptor binding
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010165 response to X-ray
GO:0014839 myoblast migration involved in skeletal muscle regeneration
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0016328 lateral plasma membrane
GO:0018149 peptide cross-linking
GO:0019221 cytokine-mediated signaling pathway
GO:0019834 phospholipase A2 inhibitor activity
GO:0019898 extrinsic component of membrane
GO:0030073 insulin secretion
GO:0030216 keratinocyte differentiation
GO:0030659 cytoplasmic vesicle membrane
GO:0030850 prostate gland development
GO:0031018 endocrine pancreas development
GO:0031232 extrinsic component of external side of plasma membrane
GO:0031313 extrinsic component of endosome membrane
GO:0031340 positive regulation of vesicle fusion
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0031514 motile cilium
GO:0031532 actin cytoskeleton reorganization
GO:0031901 early endosome membrane
GO:0031966 mitochondrial membrane
GO:0031982 vesicle
GO:0032355 response to estradiol
GO:0032508 DNA duplex unwinding
GO:0032652 regulation of interleukin-1 production
GO:0032717 negative regulation of interleukin-8 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032991 protein-containing complex
GO:0033031 positive regulation of neutrophil apoptotic process
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036121 double-stranded DNA helicase activity
GO:0042063 gliogenesis
GO:0042102 positive regulation of T cell proliferation
GO:0042383 sarcolemma
GO:0042493 response to drug
GO:0042629 mast cell granule
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045087 innate immune response
GO:0045627 positive regulation of T-helper 1 cell differentiation
GO:0045629 negative regulation of T-helper 2 cell differentiation
GO:0045920 negative regulation of exocytosis
GO:0046632 alpha-beta T cell differentiation
GO:0046883 regulation of hormone secretion
GO:0048306 calcium-dependent protein binding
GO:0050482 arachidonic acid secretion
GO:0050709 negative regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070365 hepatocyte differentiation
GO:0070459 prolactin secretion
GO:0070555 response to interleukin-1
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071621 granulocyte chemotaxis
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis
GO:0090303 positive regulation of wound healing
GO:0097060 synaptic membrane
GO:0097350 neutrophil clearance
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:1900138 negative regulation of phospholipase A2 activity
GO:1990814 DNA/DNA annealing activity

Subcellular Location

Show/Hide Table
Subcellular Location
Apical cell membrane
Basolateral cell membrane
Cell membrane
Cell projection
Cytoplasm
Cytoplasmic vesicle
Cytoplasmic vesicle membrane
Early endosome
Endosome membrane
Lateral cell membrane
Membrane
Nucleus
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR001464 AnnexinFamilyFamily
IPR002388 Annexin A1FamilyFamily
IPR018252 Annexin repeat, conserved siteSiteConserved site
IPR018502 Annexin repeatRepeatRepeat
IPR037104 Annexin superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB00288 AmcinonideDrugbanksmall molecule
DB00591 Fluocinolone acetonideDrugbanksmall molecule
DB00741 HydrocortisoneDrugbanksmall molecule
DB00959 MethylprednisoloneDrugbanksmall molecule
DB01013 Clobetasol propionateDrugbanksmall molecule
DB01222 BudesonideDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB14538 Hydrocortisone aceponateDrugbanksmall molecule
DB14539 Hydrocortisone acetateDrugbanksmall molecule
DB14540 Hydrocortisone butyrateDrugbanksmall molecule
DB14541 Hydrocortisone cypionateDrugbanksmall molecule
DB14542 Hydrocortisone phosphateDrugbanksmall molecule
DB14543 Hydrocortisone probutateDrugbanksmall molecule
DB14544 Hydrocortisone valerateDrugbanksmall molecule
DB14631 Prednisolone phosphateDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB14669 Betamethasone phosphateDrugbanksmall molecule

Interactions

54 interactions

InteractorPartnerSourcesPublicationsLink
ANXA1_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, MINT15581623 20029029 24189400 31980649 details
ANXA1_HUMANHMGA1_HUMANBioGRID, IntAct18850631 details
ANXA1_HUMANAPBB1_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANLRIF1_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANERG28_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANTCPH_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANCZIB_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANCSN6_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANCSAD_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANFAF1_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANKLH23_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANG3P_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANKMT2B_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANOTUB1_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANRFA1_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANUB2D1_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANU119A_HUMANBioGRID, MINT21900206 details
ANXA1_HUMANXRCC6_HUMANBioGRID, MINT21900206 30585729 details
ANXA1_HUMANHSPB1_HUMANBioGRID, IntAct25277244 details
ANXA1_HUMANLNP_HUMANBioGRID, IntAct32296183 details
ANXA1_HUMANZHX1R_HUMANIntAct32814053 details
ANXA1_HUMANEVA1B_HUMANIntAct32814053 details
ANXA1_HUMANLEG1H_HUMANIntAct32814053 details
ANXA1_HUMANS10AB_HUMANBioGRID, HPRD12645011 17932043 8557678 details
ANXA1_HUMANUCHL5_HUMANBioGRID21800051 details
ANXA1_HUMANUBE3A_HUMANBioGRID19204938 details
ANXA1_HUMANUBC9_HUMANBioGRID20359522 details
ANXA1_HUMAN1433T_HUMANBioGRID15161933 details
ANXA1_HUMANMEIS2_HUMANBioGRID25416956 details
ANXA1_HUMANSUMO2_HUMANBioGRID19394292 details
ANXA1_HUMANUBP7_HUMANBioGRID25695607 details
ANXA1_HUMANEPHA2_HUMANBioGRID32737118 details
ANXA1_HUMANIKBA_HUMANIntAct14743216 details
ANXA1_HUMAN1433Z_HUMANMINT15161933 details
ANXA1_HUMANNEMO_HUMANBioGRID, I2D21383699 details
ANXA1_HUMANRIPK1_HUMANBioGRID, I2D21383699 29021293 details
ANXA1_HUMANTF65_HUMANBioGRID, I2D21383699 details
ANXA1_HUMANK2C8_HUMANBioGRID, HPRD9459484 details
ANXA1_HUMANMGMT_HUMANBioGRID16226712 details
ANXA1_HUMANANXA5_HUMANBioGRID12689596 details
ANXA1_HUMANITA4_HUMANBioGRID22623428 details
ANXA1_HUMANATP4A_HUMANBioGRID17255364 details
ANXA1_HUMANZBTB1_HUMANBioGRID24657165 details
ANXA1_HUMANU2AF2_HUMANBioGRID26641092 details
ANXA1_HUMANACTS_HUMANBioGRID22773844 details
ANXA1_HUMANPA24A_HUMANBioGRID17873281 17932043 details
ANXA1_HUMANFPR1_HUMANBioGRID, HPRD10882119 24939696 details
ANXA1_HUMANP53_HUMANBioGRID27584794 details
ANXA1_HUMANISG15_HUMANBioGRID33024031 details
ANXA1_HUMANKPCI_HUMANHPRD2457390 details
ANXA1_HUMANSRC_HUMANHPRD2457390 details
ANXA1_HUMANTGM2_HUMANHPRD1670773 details
ANXA1_HUMANDYSF_HUMANHPRD14506282 details
ANXA1_HUMANTRPM7_HUMANHPRD15485879 details