Entity Details

Primary name VWF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04275
EntryNameVWF_HUMAN
FullNamevon Willebrand factor
TaxID9606
Evidenceevidence at protein level
Length2813
SequenceStatuscomplete
DateCreated1987-03-20
DateModified2021-06-02

Ontological Relatives

GenesVWF

GO terms

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GOName
GO:0002020 protease binding
GO:0002576 platelet degranulation
GO:0005178 integrin binding
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0007155 cell adhesion
GO:0007596 blood coagulation
GO:0007597 blood coagulation, intrinsic pathway
GO:0007599 hemostasis
GO:0009611 response to wounding
GO:0019865 immunoglobulin binding
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031589 cell-substrate adhesion
GO:0033093 Weibel-Palade body
GO:0042802 identical protein binding
GO:0047485 protein N-terminus binding
GO:0051087 chaperone binding
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001007 VWFC domainDomainDomain
IPR001846 von Willebrand factor, type D domainDomainDomain
IPR002035 von Willebrand factor, type ADomainDomain
IPR002919 Trypsin Inhibitor-like, cysteine rich domainDomainDomain
IPR006207 Cystine knot, C-terminalDomainDomain
IPR014853 Uncharacterised domain, cysteine-richDomainDomain
IPR032361 von Willebrand factor, VWA N-terminal domainDomainDomain
IPR036084 Serine protease inhibitor-like superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily
IPR037578 Von Willebrand factorFamilyFamily

Diseases

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Drugs

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DrugNameSourceType
DB00025 Antihemophilic factor, human recombinantDrugbankbiotech
DB05202 Egaptivon pegolDrugbankbiotech
DB06081 CaplacizumabDrugbankbiotech
DB09108 Simoctocog alfaDrugbankbiotech
DB09329 Antihemophilic Factor (Recombinant), PEGylatedDrugbankbiotech
DB11606 Susoctocog alfaDrugbankbiotech
DB11607 Efmoroctocog alfaDrugbankbiotech
DB13998 Lonoctocog alfaDrugbankbiotech
DB13999 Moroctocog alfaDrugbankbiotech
DB14738 Turoctocog alfa pegolDrugbankbiotech

Interactions

30 interactions

InteractorPartnerSourcesPublicationsLink
VWF_HUMANGP1BA_HUMANBioGRID, HPRD, IntAct, MINT12087105 12183630 15039442 2690940 6336654 7690774 details
VWF_HUMANZ512B_HUMANBioGRID, MINT15231748 details
VWF_HUMANATS13_HUMANDIP, HPRD, IntAct12775718 15824096 16221672 18492805 25512528 details
VWF_HUMANM3K3_HUMANBioGRID, IntAct20936779 details
VWF_HUMANATX7_HUMANBioGRID, IntAct21078624 details
VWF_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
VWF_HUMANRAC1_HUMANBioGRID, IntAct21988832 details
VWF_HUMANSOCS4_HUMANBioGRID, IntAct21988832 details
VWF_HUMANVWF_HUMANDIP, HPRD, MINT12121649 17895385 18182488 18492805 21857647 9331419 9553097 details
VWF_HUMANOPTN_HUMANBioGRID, IntAct23414517 details
VWF_HUMANFA8_HUMANBioGRID, DIP, HPRD18492805 3134349 9218428 details
VWF_HUMANLIAT1_HUMANIntAct32814053 details
VWF_HUMANASCL4_HUMANIntAct32814053 details
VWF_HUMANEGFL8_HUMANIntAct32814053 details
VWF_HUMANTP53B_HUMANIntAct32814053 details
VWF_HUMANCO1A1_HUMANBioGRID, HPRD3490481 details
VWF_HUMANPDIA1_HUMANBioGRID26670633 details
VWF_HUMANCO3A1_HUMANBioGRID16420575 details
VWF_HUMANH4_HUMANBioGRID, IntAct30021884 details
VWF_HUMANFXR1_HUMANMINT21653829 details
VWF_HUMANHXA1_HUMANMINT21653829 details
VWF_HUMANNUFP2_HUMANMINT21653829 details
VWF_HUMANENPL_HUMANBioGRID10887119 details
VWF_HUMANBIP_HUMANBioGRID, HPRD10887119 details
VWF_HUMANPDIA4_HUMANBioGRID10887119 details
VWF_HUMANCALR_HUMANBioGRID, HPRD10887119 details
VWF_HUMANITA2B_HUMANHPRD1737795 details
VWF_HUMANTR11B_HUMANHPRD15799029 details
VWF_HUMANCO1A2_HUMANHPRD3490481 details
VWF_HUMANFURIN_HUMANHPRD1571548 details