Entity Details

Primary name CP1A1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP04798
EntryNameCP1A1_HUMAN
FullNameCytochrome P450 1A1
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCYP1A1

GO terms

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GOName
GO:0001666 response to hypoxia
GO:0002933 lipid hydroxylation
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0005743 mitochondrial inner membrane
GO:0005789 endoplasmic reticulum membrane
GO:0006306 DNA methylation
GO:0006631 fatty acid metabolic process
GO:0006694 steroid biosynthetic process
GO:0006778 porphyrin-containing compound metabolic process
GO:0007568 aging
GO:0008202 steroid metabolic process
GO:0008210 estrogen metabolic process
GO:0008283 cell population proliferation
GO:0008391 arachidonic acid monooxygenase activity
GO:0009308 amine metabolic process
GO:0009611 response to wounding
GO:0009615 response to virus
GO:0009624 response to nematode
GO:0009635 response to herbicide
GO:0009692 ethylene metabolic process
GO:0009804 coumarin metabolic process
GO:0009812 flavonoid metabolic process
GO:0010041 response to iron(III) ion
GO:0016491 oxidoreductase activity
GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors
GO:0016711 flavonoid 3'-monooxygenase activity
GO:0017143 insecticide metabolic process
GO:0017144 drug metabolic process
GO:0019222 regulation of metabolic process
GO:0019341 dibenzo-p-dioxin catabolic process
GO:0019373 epoxygenase P450 pathway
GO:0019825 oxygen binding
GO:0019899 enzyme binding
GO:0020037 heme binding
GO:0030544 Hsp70 protein binding
GO:0032094 response to food
GO:0032451 demethylase activity
GO:0032496 response to lipopolysaccharide
GO:0033189 response to vitamin A
GO:0035902 response to immobilization stress
GO:0042359 vitamin D metabolic process
GO:0042493 response to drug
GO:0042572 retinol metabolic process
GO:0042759 long-chain fatty acid biosynthetic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0043010 camera-type eye development
GO:0043231 intracellular membrane-bounded organelle
GO:0046677 response to antibiotic
GO:0046685 response to arsenic-containing substance
GO:0048565 digestive tract development
GO:0050665 hydrogen peroxide biosynthetic process
GO:0051879 Hsp90 protein binding
GO:0055093 response to hyperoxia
GO:0060137 maternal process involved in parturition
GO:0070330 aromatase activity
GO:0070365 hepatocyte differentiation
GO:0070576 vitamin D 24-hydroxylase activity
GO:0071280 cellular response to copper ion
GO:0071407 cellular response to organic cyclic compound
GO:0097267 omega-hydroxylase P450 pathway
GO:0101020 estrogen 16-alpha-hydroxylase activity
GO:0101021 estrogen 2-hydroxylase activity
GO:0106256 hydroperoxy icosatetraenoate dehydratase activity
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR008066 Cytochrome P450, E-class, group I, CYP1FamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00165 PyridoxineDrugbanksmall molecule
DB00169 CholecalciferolDrugbanksmall molecule
DB00170 MenadioneDrugbanksmall molecule
DB00176 FluvoxamineDrugbanksmall molecule
DB00184 NicotineDrugbanksmall molecule
DB00197 TroglitazoneDrugbanksmall molecule
DB00201 CaffeineDrugbanksmall molecule
DB00277 TheophyllineDrugbanksmall molecule
DB00317 GefitinibDrugbanksmall molecule
DB00325 NitroprussideDrugbanksmall molecule
DB00338 OmeprazoleDrugbanksmall molecule
DB00356 ChlorzoxazoneDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00381 AmlodipineDrugbanksmall molecule
DB00396 ProgesteroneDrugbanksmall molecule
DB00428 StreptozocinDrugbanksmall molecule
DB00448 LansoprazoleDrugbanksmall molecule
DB00455 LoratadineDrugbanksmall molecule
DB00466 PicrotoxinDrugbanksmall molecule
DB00468 QuinineDrugbanksmall molecule
DB00499 FlutamideDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00518 AlbendazoleDrugbanksmall molecule
DB00530 ErlotinibDrugbanksmall molecule
DB00539 ToremifeneDrugbanksmall molecule
DB00550 PropylthiouracilDrugbanksmall molecule
DB00553 MethoxsalenSwissprotsmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00575 ClonidineDrugbanksmall molecule
DB00605 SulindacDrugbanksmall molecule
DB00608 ChloroquineDrugbanksmall molecule
DB00613 AmodiaquineDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB00633 DexmedetomidineDrugbanksmall molecule
DB00636 ClofibrateDrugbanksmall molecule
DB00643 MebendazoleDrugbanksmall molecule
DB00655 EstroneDrugbanksmall molecule
DB00675 TamoxifenDrugbanksmall molecule
DB00694 DaunorubicinDrugbanksmall molecule
DB00730 ThiabendazoleDrugbanksmall molecule
DB00738 PentamidineDrugbanksmall molecule
DB00740 RiluzoleDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB00783 EstradiolDrugbanksmall molecule
DB00818 PropofolDrugbanksmall molecule
DB00851 DacarbazineDrugbanksmall molecule
DB00889 GranisetronDrugbanksmall molecule
DB00898 EthanolDrugbanksmall molecule
DB00908 QuinidineDrugbanksmall molecule
DB00972 AzelastineDrugbanksmall molecule
DB01026 KetoconazoleDrugbanksmall molecule
DB01041 ThalidomideDrugbanksmall molecule
DB01059 NorfloxacinDrugbanksmall molecule
DB01064 IsoprenalineDrugbanksmall molecule
DB01065 MelatoninDrugbanksmall molecule
DB01087 PrimaquineDrugbanksmall molecule
DB01095 FluvastatinDrugbanksmall molecule
DB01115 NifedipineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01129 RabeprazoleDrugbanksmall molecule
DB01132 PioglitazoneDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01167 ItraconazoleDrugbanksmall molecule
DB01174 PhenobarbitalDrugbanksmall molecule
DB01234 DexamethasoneDrugbanksmall molecule
DB01254 DasatinibDrugbanksmall molecule
DB01393 BezafibrateDrugbanksmall molecule
DB01407 ClenbuterolDrugbanksmall molecule
DB01591 SolifenacinDrugbanksmall molecule
DB01685 TopiroxostatDrugbanksmall molecule
DB02342 2-MethoxyestradiolDrugbanksmall molecule
DB02709 ResveratrolDrugbanksmall molecule
DB03783 PhenacetinDrugbanksmall molecule
DB04840 DebrisoquineDrugbanksmall molecule
DB04841 FlunarizineDrugbanksmall molecule
DB04871 LorcaserinDrugbanksmall molecule
DB04905 TesmilifeneDrugbanksmall molecule
DB04957 AzimilideDrugbanksmall molecule
DB04975 BanoxantroneDrugbanksmall molecule
DB05928 DovitinibDrugbanksmall molecule
DB06176 RomidepsinDrugbanksmall molecule
DB06292 DapagliflozinDrugbanksmall molecule
DB06654 SafinamideDrugbanksmall molecule
DB06770 Benzyl alcoholSwissprotsmall molecule
DB08496 (R)-warfarinSwissprotsmall molecule
DB08846 Ellagic acidDrugbanksmall molecule
DB08922 PerospironeDrugbanksmall molecule
DB08931 RiociguatDrugbanksmall molecule
DB09061 CannabidiolDrugbanksmall molecule
DB09238 ManidipineDrugbanksmall molecule
DB11155 TriclocarbanDrugbanksmall molecule
DB11511 DifloxacinSwissprotsmall molecule
DB11757 IstradefyllineDrugbanksmall molecule
DB12245 TriclabendazoleDrugbanksmall molecule
DB12379 IndirubinDrugbanksmall molecule
DB12483 CopanlisibDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule
DB13952 Estradiol acetateDrugbanksmall molecule
DB13953 Estradiol benzoateDrugbanksmall molecule
DB13954 Estradiol cypionateDrugbanksmall molecule
DB13955 Estradiol dienanthateDrugbanksmall molecule
DB13956 Estradiol valerateDrugbanksmall molecule
DB14009 Medical CannabisDrugbankbiotech
DB14011 NabiximolsDrugbanksmall molecule
DB14649 Dexamethasone acetateDrugbanksmall molecule
DB15305 RisdiplamSwissprotsmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CP1A1_HUMANCKLF5_HUMANBioGRID, IntAct25416956 25910212 details
CP1A1_HUMANCYB5_HUMANHPRD6102994 details