Entity Details

Primary name ITB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05107
EntryNameITB2_HUMAN
FullNameIntegrin beta-2
TaxID9606
Evidenceevidence at protein level
Length769
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesITGB2

GO terms

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GOName
GO:0001540 amyloid-beta binding
GO:0001774 microglial cell activation
GO:0001851 complement component C3b binding
GO:0002523 leukocyte migration involved in inflammatory response
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006898 receptor-mediated endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007568 aging
GO:0008305 integrin complex
GO:0008360 regulation of cell shape
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016477 cell migration
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0030101 natural killer cell activation
GO:0030198 extracellular matrix organization
GO:0030369 ICAM-3 receptor activity
GO:0030593 neutrophil chemotaxis
GO:0031072 heat shock protein binding
GO:0031623 receptor internalization
GO:0032930 positive regulation of superoxide anion generation
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034687 integrin alphaL-beta2 complex
GO:0034688 integrin alphaM-beta2 complex
GO:0034689 integrin alphaX-beta2 complex
GO:0035579 specific granule membrane
GO:0035987 endodermal cell differentiation
GO:0043113 receptor clustering
GO:0043235 receptor complex
GO:0043312 neutrophil degranulation
GO:0043315 positive regulation of neutrophil degranulation
GO:0043542 endothelial cell migration
GO:0044853 plasma membrane raft
GO:0045123 cellular extravasation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045963 negative regulation of dopamine metabolic process
GO:0046872 metal ion binding
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050900 leukocyte migration
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0090314 positive regulation of protein targeting to membrane
GO:0097242 amyloid-beta clearance
GO:0098609 cell-cell adhesion
GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules
GO:0101003 ficolin-1-rich granule membrane
GO:1901216 positive regulation of neuron death
GO:1903561 extracellular vesicle
GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell
GO:1990266 neutrophil migration
GO:2000363 positive regulation of prostaglandin-E synthase activity

Subcellular Location

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Subcellular Location
Cell membrane
Membrane raft

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015439 Integrin beta-2 subunitFamilyFamily
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

71 interactions

InteractorPartnerSourcesPublicationsLink
ITB2_HUMANCSN3_HUMANHPRD, MINT10766246 details
ITB2_HUMANRANB9_HUMANBioGRID, HPRD, MINT14722085 details
ITB2_HUMANRADI_HUMANHPRD, MINT17321526 details
ITB2_HUMANCYH1_HUMANBioGRID, HPRD, MINT10835351 17321526 9765275 details
ITB2_HUMANTLN2_HUMANMINT19234221 details
ITB2_HUMANLYN_HUMANmbinfo14593208 details
ITB2_HUMANITAX_HUMANDIP, HPRD, I2D11937543 20033057 20679211 7621072 details
ITB2_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
ITB2_HUMANNT2NA_HUMANBioGRID, IntAct25416956 25910212 31515488 32296183 details
ITB2_HUMANNT2NC_HUMANBioGRID, IntAct25416956 25910212 32296183 details
ITB2_HUMANCRTP1_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANSCML1_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANT4S18_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANIF3M_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANMS4A7_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANLHPL5_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANAPOL2_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANATL4_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANKR108_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANK1H1_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANUPK1B_HUMANBioGRID, IntAct32296183 details
ITB2_HUMANX3CL1_HUMANIntAct24789099 details
ITB2_HUMANFX4L6_HUMANIntAct32814053 details
ITB2_HUMANKEAP1_HUMANIntAct32814053 details
ITB2_HUMANRACK1_HUMANBioGRID, HPRD9442085 details
ITB2_HUMANICAM1_HUMANBioGRID, HPRD10352278 11279101 20187292 7642561 details
ITB2_HUMANFHL2_HUMANBioGRID, HPRD10906324 details
ITB2_HUMANKNG1_HUMANBioGRID, HPRD10845911 details
ITB2_HUMANCSN5_HUMANBioGRID10766246 details
ITB2_HUMANKPCB_HUMANBioGRID, HPRD11700305 details
ITB2_HUMANKPCD_HUMANBioGRID, HPRD11700305 details
ITB2_HUMANKPCA_HUMANBioGRID, HPRD11700305 details
ITB2_HUMANKPCE_HUMANBioGRID11700305 details
ITB2_HUMANKPCG_HUMANBioGRID11700305 details
ITB2_HUMANCO3_HUMANBioGRID4062888 details
ITB2_HUMANSHRPN_HUMANBioGRID26600301 details
ITB2_HUMANCYH2_HUMANHPRD8706128 details
ITB2_HUMANKSYK_HUMANBioGRID, HPRD, IntAct10961871 12885943 details
ITB2_HUMANABL1_HUMANMINT19234221 details
ITB2_HUMANVAV_HUMANMINT19234221 details
ITB2_HUMANCD177_HUMANUniProt21193407 details
ITB2_HUMANBGH3_HUMANIntAct18083624 details
ITB2_HUMANITAM_HUMANHPRD, IntAct18083624 2454931 details
ITB2_HUMANUPAR_HUMANBioGRID10388537 details
ITB2_HUMANITAL_HUMANBioGRID9442085 details
ITB2_HUMANITAD_HUMANBioGRID, HPRD8777714 details
ITB2_HUMANFAK2_HUMANBioGRID, HPRD10961871 details
ITB2_HUMANVNN2_HUMANBioGRID, HPRD12056825 details
ITB2_HUMANCD226_HUMANBioGRID, HPRD10591186 details
ITB2_HUMANPSMD4_HUMANBioGRID16762342 details
ITB2_HUMAN1433B_HUMANBioGRID11700305 18239087 details
ITB2_HUMAN1433Z_HUMANBioGRID11700305 details
ITB2_HUMANPLSL_HUMANBioGRID30333137 details
ITB2_HUMANPRTN3_HUMANHPRD12960243 details
ITB2_HUMANTLN1_HUMANHPRD12606711 2150484 details
ITB2_HUMANITB2_HUMANHPRD9419363 details
ITB2_HUMANESM1_HUMANHPRD11544294 details
ITB2_HUMANICAM5_HUMANHPRD8995416 details
ITB2_HUMANILK_HUMANHPRD9736715 details
ITB2_HUMANDOK1_HUMANHPRD12606711 details
ITB2_HUMANDAB1_HUMANHPRD12606711 details
ITB2_HUMANNUMB_HUMANHPRD12606711 details
ITB2_HUMANKPCL_HUMANHPRD11700305 details
ITB2_HUMANCD82_HUMANHPRD10602019 details
ITB2_HUMANICAM4_HUMANHPRD10846180 details
ITB2_HUMANHPT_HUMANHPRD11967116 details
ITB2_HUMANICAM2_HUMANHPRD9786897 details
ITB2_HUMANICAM3_HUMANHPRD11353828 7822326 details
ITB2_HUMANFUT4_HUMANHPRD3305706 details
ITB2_HUMANFCER2_HUMANHPRD7621072 details
ITB2_HUMANCD14_HUMANHPRD11745332 details