Entity Details

Primary name CP11A_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP05108
EntryNameCP11A_HUMAN
FullNameCholesterol side-chain cleavage enzyme, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length521
SequenceStatuscomplete
DateCreated1987-08-13
DateModified2021-06-02

Ontological Relatives

GenesCYP11A1

GO terms

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GOName
GO:0005506 iron ion binding
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006700 C21-steroid hormone biosynthetic process
GO:0006704 glucocorticoid biosynthetic process
GO:0008203 cholesterol metabolic process
GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity
GO:0016125 sterol metabolic process
GO:0020037 heme binding
GO:0034650 cortisol metabolic process
GO:0042359 vitamin D metabolic process
GO:0071375 cellular response to peptide hormone stimulus

Subcellular Location

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Subcellular Location
Mitochondrion inner membrane

Domains

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DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002401 Cytochrome P450, E-class, group IFamilyFamily
IPR017972 Cytochrome P450, conserved siteSiteConserved site
IPR033283 Cholesterol side-chain cleavage enzyme, mitochondrialFamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00153 ErgocalciferolDrugbanksmall molecule
DB00169 CholecalciferolDrugbanksmall molecule
DB00357 AminoglutethimideDrugbanksmall molecule
DB00390 DigoxinDrugbanksmall molecule
DB00624 TestosteroneDrugbanksmall molecule
DB01396 DigitoxinDrugbanksmall molecule
DB01437 GlutethimideDrugbanksmall molecule
DB02901 StanoloneDrugbanksmall molecule
DB13943 Testosterone cypionateDrugbanksmall molecule
DB13944 Testosterone enanthateDrugbanksmall molecule
DB13946 Testosterone undecanoateDrugbanksmall molecule

Interactions

6 interactions