Entity Details

Primary name LCK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06239
EntryNameLCK_HUMAN
FullNameTyrosine-protein kinase Lck
TaxID9606
Evidenceevidence at protein level
Length509
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesLCK

GO terms

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GOName
GO:0000242 pericentriolar material
GO:0001772 immunological synapse
GO:0001784 phosphotyrosine residue binding
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0006882 cellular zinc ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008022 protein C-terminus binding
GO:0016004 phospholipase activator activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0030097 hemopoiesis
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030217 T cell differentiation
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0035556 intracellular signal transduction
GO:0042169 SH2 domain binding
GO:0042493 response to drug
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043274 phospholipase binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0050690 regulation of defense response to virus by virus
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0050870 positive regulation of T cell activation
GO:0050900 leukocyte migration
GO:0051117 ATPase binding
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051249 regulation of lymphocyte activation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035749 Lck, SH3 domainDomainDomain
IPR035850 Tyrosine-protein kinase Lck, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB01830 AP-22408Drugbanksmall molecule
DB02010 StaurosporineDrugbanksmall molecule
DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB04003 {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acidDrugbanksmall molecule
DB04395 Phosphoaminophosphonic Acid-Adenylate EsterDrugbanksmall molecule
DB06925 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDEDrugbanksmall molecule
DB07146 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINEDrugbanksmall molecule
DB07297 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINEDrugbanksmall molecule
DB08055 N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDrugbanksmall molecule
DB08056 N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amineDrugbanksmall molecule
DB08057 N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amineDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

170 interactions

InteractorPartnerSourcesPublicationsLink
LCK_HUMANKSYK_HUMANBioGRID, HPRD, MINT15536084 7539035 8621719 8798676 8798764 details
LCK_HUMANCBL_HUMANBioGRID, HPRD, MINT11741956 11904433 16107303 7721825 8621719 8626543 8900205 9178909 details
LCK_HUMANPTPRC_HUMANBioGRID, DIP, HPRD, IntAct, MINT10330160 10369126 11369760 12589038 14625311 15085197 19167335 24463463 7507203 8473339 8576115 8663450 9533446 9973453 details
LCK_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct, MINT11278465 16107303 16274251 16888650 7852312 9045636 details
LCK_HUMANCD2_HUMANBioGRID, HPRD, MINT8551220 9677430 details
LCK_HUMANSH21A_HUMANHPRD, IntAct, MINT15096483 24688028 details
LCK_HUMANLCP2_HUMANHPRD, MINT10556826 16354835 21725281 8702662 details
LCK_HUMANZAP70_HUMANBioGRID, HPRD, IntAct, MINT10318843 10556826 15144186 16461343 22242145 7539035 7961936 8798643 9685404 details
LCK_HUMANMK01_HUMANBioGRID, HPRD, MINT15967991 8506364 8618896 8626561 details
LCK_HUMANCD3Z_HUMANBioGRID, DIP, HPRD, IntAct, MINT14523017 16461343 24463463 26390156 8626561 9047237 details
LCK_HUMANG3BP1_HUMANBioGRID, MINT15743820 details
LCK_HUMANP85A_HUMANBioGRID, HPRD, MINT34079125 7504174 8246987 8294442 9461588 details
LCK_HUMANCD4_HUMANBioGRID, HPRD, MINT11854499 12007789 15047060 16888650 17005671 17653867 8104794 8246987 details
LCK_HUMANDLG1_HUMANBioGRID, HPRD, IntAct, MINT25241761 9341123 details
LCK_HUMANWASL_HUMANBioGRID, IntAct16293614 details
LCK_HUMANMED28_HUMANHPRD, IntAct10656681 16899217 details
LCK_HUMANPTN22_HUMANBioGRID, HPRD, IntAct16461343 19167335 21719704 details
LCK_HUMANLAT_HUMANBioGRID, HPRD, IntAct12186560 12359715 14523017 16938345 details
LCK_HUMANPTPRM_HUMANIntAct19167335 details
LCK_HUMANPTPRK_HUMANIntAct19167335 details
LCK_HUMANPTPRG_HUMANIntAct19167335 details
LCK_HUMANPTPRZ_HUMANIntAct19167335 details
LCK_HUMANPTPRB_HUMANIntAct19167335 details
LCK_HUMANPTPRJ_HUMANIntAct19167335 details
LCK_HUMANPTPRO_HUMANIntAct19167335 details
LCK_HUMANPTN6_HUMANBioGRID, HPRD, IntAct, MINT10488096 10574931 10617656 11294838 12468540 19167335 7512963 8114715 8692915 details
LCK_HUMANPTN12_HUMANIntAct19167335 details
LCK_HUMANLCK_HUMANBioGRID, DIP, HPRD, MINT15144186 17118402 20372794 24463463 31980649 8258691 8405050 8879209 8945479 9533446 details
LCK_HUMANWASP_HUMANBioGRID, MINT16107303 16293614 details
LCK_HUMANADA15_HUMANBioGRID, HPRD, MINT, UniProt11741929 16374509 25825872 details
LCK_HUMANMED25_HUMANMINT19290556 details
LCK_HUMANUBC_HUMANBioGRID, MINT18539162 details
LCK_HUMANABI1_HUMANBioGRID, MINT20598684 34079125 details
LCK_HUMANPHAG1_HUMANBioGRID, HPRD, MINT10790433 18070987 details
LCK_HUMANSTAT3_HUMANBioGRID, HPRD, IntAct, MINT10825200 18070987 25814554 details
LCK_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
LCK_HUMANKPCT_HUMANBioGRID, HPRD, InnateDB10383400 10652356 21964608 details
LCK_HUMANNEMO_HUMANBioGRID, IntAct20098747 details
LCK_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
LCK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
LCK_HUMANGAB1_HUMANBioGRID, IntAct24728074 34079125 details
LCK_HUMANKIT_HUMANBioGRID, HPRD, IntAct24728074 9788619 details
LCK_HUMANMET_HUMANBioGRID, IntAct24728074 details
LCK_HUMANDOK2_HUMANBioGRID, HPRD, IntAct10799545 15831486 25814554 details
LCK_HUMANRIN3_HUMANBioGRID, IntAct25814554 details
LCK_HUMANCDKAL_HUMANBioGRID, IntAct25416956 details
LCK_HUMANLZTS2_HUMANBioGRID, IntAct25416956 34079125 details
LCK_HUMANGATA3_HUMANBioGRID, IntAct26871637 details
LCK_HUMANRORB_HUMANIntAct32296183 details
LCK_HUMANUBAP2_HUMANBioGRID, IntAct32296183 details
LCK_HUMANC1QT2_HUMANBioGRID, IntAct32296183 details
LCK_HUMANCTDS1_HUMANBioGRID, IntAct32296183 details
LCK_HUMANF166B_HUMANBioGRID, IntAct32296183 details
LCK_HUMANIKBD_HUMANBioGRID, IntAct32296183 details
LCK_HUMANTRI35_HUMANBioGRID, IntAct32296183 details
LCK_HUMANASB9_HUMANBioGRID, IntAct32296183 details
LCK_HUMANTHMS1_HUMANIntAct23460737 details
LCK_HUMANTNR6_HUMANBioGRID, DIP, HPRD20696918 8864141 details
LCK_HUMANFLT3_HUMANMINT28086240 details
LCK_HUMANADA10_HUMANBioGRID, UniProt11741929 25036101 details
LCK_HUMANU119A_HUMANBioGRID, HPRD14757743 details
LCK_HUMANPK3CA_HUMANBioGRID, HPRD14583609 8020561 8246987 details
LCK_HUMANCTND1_HUMANBioGRID12835311 34079125 details
LCK_HUMANUFO_HUMANBioGRID, HPRD9178760 details
LCK_HUMANUBE3A_HUMANBioGRID10449731 details
LCK_HUMANBCAR1_HUMANBioGRID, HPRD9020138 details
LCK_HUMANSKAP1_HUMANBioGRID, HPRD10229084 9195899 details
LCK_HUMANPI4KA_HUMANBioGRID34079125 8246987 details
LCK_HUMANRHG17_HUMANBioGRID, HPRD11431473 details
LCK_HUMANTRAT1_HUMANBioGRID, HPRD10790433 9687533 details
LCK_HUMANTNFL6_HUMANBioGRID, HPRD11741599 details
LCK_HUMANPECA1_HUMANBioGRID, HPRD9624175 details
LCK_HUMANSQSTM_HUMANBioGRID, HPRD8650207 details
LCK_HUMANRASA1_HUMANBioGRID, HPRD11389730 1850098 details
LCK_HUMANF174A_HUMANBioGRID16274251 details
LCK_HUMANSOS1_HUMANBioGRID16274251 details
LCK_HUMANSOCS1_HUMANBioGRID21234523 31101761 details
LCK_HUMANAJUBA_HUMANBioGRID15870274 details
LCK_HUMANPAK2_HUMANBioGRID, HPRD16374509 details
LCK_HUMANSMAD2_HUMANBioGRID16806069 details
LCK_HUMANSMAD3_HUMANBioGRID16806069 details
LCK_HUMANBRCA1_HUMANBioGRID25184681 details
LCK_HUMANSMUF1_HUMANBioGRID20804422 details
LCK_HUMANFAK1_HUMANBioGRID26871637 details
LCK_HUMANPTPRF_HUMANBioGRID, HPRD12496362 details
LCK_HUMANCDC45_HUMANBioGRID14625311 details
LCK_HUMANFYN_HUMANBioGRID7520528 details
LCK_HUMANPTPRH_HUMANBioGRID, HPRD12837766 details
LCK_HUMANTAU_HUMANBioGRID21269457 9763511 details
LCK_HUMANSKAP2_HUMANBioGRID29568343 details
LCK_HUMANEGFR_HUMANBioGRID22973453 details
LCK_HUMANERBB2_HUMANBioGRID22973453 details
LCK_HUMANERBB3_HUMANBioGRID22973453 details
LCK_HUMANERBB4_HUMANBioGRID22973453 details
LCK_HUMANSH22A_HUMANHPRD, IntAct, MINT10553045 15827961 16839418 details
LCK_HUMANHS90A_HUMANBioGRID, HPRD, IntAct, MINT16888650 22939624 31980649 details
LCK_HUMANGCR_HUMANBioGRID, HPRD, MINT16888650 details
LCK_HUMANBCL3_HUMANMINT16099425 details
LCK_HUMANVAV_HUMANHPRD, MINT10669745 17050525 details
LCK_HUMAN3BP2_HUMANHPRD, MINT15751964 details
LCK_HUMANCD3E_HUMANBioGRID, HPRD, MINT11855827 14523017 details
LCK_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
LCK_HUMANDAF_HUMANBioGRID, HPRD, IntAct1385527 25241761 details
LCK_HUMANHAVR2_HUMANBioGRID, UniProt22863785 26492563 details
LCK_HUMANSLAF6_HUMANIntAct24688028 details
LCK_HUMANCSK_HUMANBioGRID, HPRD, IntAct12485116 15144186 31980649 details
LCK_HUMANNOTC1_HUMANBioGRID, HPRD14583609 details
LCK_HUMANFAK2_HUMANBioGRID, HPRD9091579 details
LCK_HUMANCD44_HUMANBioGRID, HPRD8576267 9573028 details
LCK_HUMANPAXI_HUMANBioGRID, HPRD9488700 details
LCK_HUMANSH2B3_HUMANBioGRID, HPRD10799879 9169414 details
LCK_HUMANCD20_HUMANBioGRID, HPRD7545683 details
LCK_HUMANCASL_HUMANBioGRID, HPRD8879209 details
LCK_HUMANCD48_HUMANBioGRID, HPRD12007789 8104794 details
LCK_HUMANCTLA4_HUMANBioGRID, HPRD9712716 9973379 details
LCK_HUMANTRPV4_HUMANBioGRID, HPRD12538589 details
LCK_HUMANSIT1_HUMANBioGRID, HPRD10209036 details
LCK_HUMANTHY1_HUMANBioGRID, HPRD1351058 8104794 details
LCK_HUMANRAF1_HUMANBioGRID, HPRD8939988 details
LCK_HUMANSH3K1_HUMANBioGRID15707590 details
LCK_HUMANCD38_HUMANBioGRID, HPRD10636863 14523017 details
LCK_HUMANCBLB_HUMANBioGRID21453975 details
LCK_HUMANCD5_HUMANBioGRID, HPRD11298344 15144186 21757751 7513045 details
LCK_HUMANIL2RB_HUMANBioGRID, HPRD10214954 2047859 21834013 details
LCK_HUMANSOCS2_HUMANBioGRID21234523 details
LCK_HUMANSOCS3_HUMANBioGRID21234523 details
LCK_HUMANCISH_HUMANBioGRID21234523 details
LCK_HUMAN1433T_HUMANBioGRID19010391 details
LCK_HUMANBAG6_HUMANBioGRID22863785 29706626 details
LCK_HUMANFCG3A_HUMANBioGRID, HPRD15144186 8258691 8405050 8945479 details
LCK_HUMANPTCA_HUMANBioGRID7499298 details
LCK_HUMANCD8A_HUMANHPRD14500983 details
LCK_HUMANCD79B_HUMANHPRD8077654 details
LCK_HUMANINAR1_HUMANHPRD9403695 details
LCK_HUMANCD79A_HUMANHPRD10748115 8077654 details
LCK_HUMANCSF3R_HUMANHPRD9790917 details
LCK_HUMANIL3RB_HUMANHPRD1638019 7896837 details
LCK_HUMANMUC1_HUMANHPRD14766232 details
LCK_HUMANSTA5A_HUMANHPRD10825200 details
LCK_HUMANESR2_HUMANHPRD12415108 details
LCK_HUMANGRAP_HUMANHPRD8995379 details
LCK_HUMANGAB2_HUMANHPRD11572860 details
LCK_HUMANLIME1_HUMANHPRD14610044 details
LCK_HUMANLAX1_HUMANHPRD12359715 details
LCK_HUMANEZRI_HUMANHPRD12560083 1382070 details
LCK_HUMANESR1_HUMANHPRD7539106 details
LCK_HUMANMPIP3_HUMANHPRD11389730 details
LCK_HUMANIKBA_HUMANHPRD12429743 8797825 9792645 details
LCK_HUMANPLCG1_HUMANHPRD1500851 details
LCK_HUMANPTN11_HUMANHPRD10617656 details
LCK_HUMANKPCA_HUMANHPRD8506364 details
LCK_HUMANKPCD_HUMANHPRD11381116 details
LCK_HUMANCD28_HUMANHPRD10430626 details
LCK_HUMANITK_HUMANHPRD15144186 9312162 details
LCK_HUMANJAK3_HUMANHPRD11278738 details
LCK_HUMANPLCG2_HUMANHPRD12181444 15144186 7682059 details
LCK_HUMANSTAT1_HUMANHPRD10918587 11294897 11839738 12637327 12817007 15322115 7543024 7657660 7690989 details
LCK_HUMANSHC1_HUMANHPRD10482988 10764799 10816433 10896916 10921922 11075717 12237775 9121430 9446569 9710204 9741627 details
LCK_HUMANTUB_HUMANHPRD10455176 details
LCK_HUMANCCR5_HUMANHPRD11591716 details
LCK_HUMANKAPCA_HUMANHPRD8506364 details
LCK_HUMANMK03_HUMANHPRD8506364 8618896 details
LCK_HUMANPLD2_HUMANHPRD12697812 details
LCK_HUMANDOK1_HUMANHPRD10799545 details
LCK_HUMANDAPP1_HUMANHPRD10880360 details
LCK_HUMANPPAC_HUMANHPRD9038134 details
LCK_HUMANCTND2_HUMANHPRD12835311 details
LCK_HUMANDEFI6_HUMANHPRD12923183 details
LCK_HUMANDOK3_HUMANHPRD10733577 details
LCK_HUMANKI2L3_HUMANHPRD9751747 details