Entity Details

Primary name CRF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP06850
EntryNameCRF_HUMAN
FullNameCorticoliberin
TaxID9606
Evidenceevidence at protein level
Length196
SequenceStatuscomplete
DateCreated1988-01-01
DateModified2021-06-02

Ontological Relatives

GenesCRH

GO terms

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GOName
GO:0001934 positive regulation of protein phosphorylation
GO:0001963 synaptic transmission, dopaminergic
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0005102 signaling receptor binding
GO:0005179 hormone activity
GO:0005184 neuropeptide hormone activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007565 female pregnancy
GO:0007567 parturition
GO:0007611 learning or memory
GO:0008202 steroid metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008306 associative learning
GO:0008628 hormone-mediated apoptotic signaling pathway
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010700 negative regulation of norepinephrine secretion
GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness
GO:0010942 positive regulation of cell death
GO:0014062 regulation of serotonin secretion
GO:0016101 diterpenoid metabolic process
GO:0017045 corticotropin-releasing hormone activity
GO:0021854 hypothalamus development
GO:0032811 negative regulation of epinephrine secretion
GO:0033685 negative regulation of luteinizing hormone secretion
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0035902 response to immobilization stress
GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep
GO:0042493 response to drug
GO:0043196 varicosity
GO:0043204 perikaryon
GO:0043627 response to estrogen
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0045202 synapse
GO:0045471 response to ethanol
GO:0045472 response to ether
GO:0048265 response to pain
GO:0050801 ion homeostasis
GO:0051412 response to corticosterone
GO:0051430 corticotropin-releasing hormone receptor 1 binding
GO:0051431 corticotropin-releasing hormone receptor 2 binding
GO:0051461 positive regulation of corticotropin secretion
GO:0051464 positive regulation of cortisol secretion
GO:0060291 long-term synaptic potentiation
GO:0060456 positive regulation of digestive system process
GO:0060548 negative regulation of cell death
GO:0070093 negative regulation of glucagon secretion
GO:0071314 cellular response to cocaine
GO:0071549 cellular response to dexamethasone stimulus
GO:0090280 positive regulation of calcium ion import
GO:2000310 regulation of NMDA receptor activity
GO:2000854 positive regulation of corticosterone secretion
GO:2000987 positive regulation of behavioral fear response

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000187 Corticotropin-releasing factorDomainDomain
IPR003620 Urocortin/corticotropin-releasing factorFamilyFamily
IPR018446 Corticotropin-releasing factor conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB01285 CorticotropinDrugbankbiotech
DB02556 D-PhenylalanineDrugbanksmall molecule
DB02952 2-aminoisobutyric acidDrugbanksmall molecule