Entity Details

Primary name PROF1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07737
EntryNamePROF1_HUMAN
FullNameProfilin-1
TaxID9606
Evidenceevidence at protein level
Length140
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesPFN1

GO terms

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GOName
GO:0000774 adenyl-nucleotide exchange factor activity
GO:0001784 phosphotyrosine residue binding
GO:0003723 RNA binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0010634 positive regulation of epithelial cell migration
GO:0016020 membrane
GO:0030036 actin cytoskeleton organization
GO:0030833 regulation of actin filament polymerization
GO:0030837 negative regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032781 positive regulation of ATPase activity
GO:0045296 cadherin binding
GO:0050821 protein stabilization
GO:0051497 negative regulation of stress fiber assembly
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0070062 extracellular exosome
GO:0070064 proline-rich region binding
GO:0072562 blood microparticle
GO:1900029 positive regulation of ruffle assembly

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR005454 Profilin1/2/3, vertebrateFamilyFamily
IPR005455 ProfilinFamilyFamily
IPR027310 Profilin conserved siteSiteConserved site
IPR029892 Profilin-1FamilyFamily
IPR036140 Profilin superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB07908 7-HYDROXY-4-METHYL-3-(2-HYDROXY-ETHYL)COUMARINDrugbanksmall molecule
DB11638 ArtenimolDrugbanksmall molecule

Interactions

40 interactions

InteractorPartnerSourcesPublicationsLink
PROF1_HUMANDPYL1_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANU119A_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANERG28_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANDLG5_HUMANBioGRID, HPRD, IntAct16169070 34079125 details
PROF1_HUMANTLE1_HUMANBioGRID, HPRD, IntAct16169070 details
PROF1_HUMANACTB_HUMANBioGRID, DIP, HPRD, IntAct10411937 19000816 19338310 details
PROF1_HUMANRAD51_HUMANBioGRID, IntAct19338310 details
PROF1_HUMANWASF1_HUMANBioGRID, HPRD, mbinfo9843499 details
PROF1_HUMANSRPK1_HUMANBioGRID, IntAct23602568 details
PROF1_HUMANZNF16_HUMANUniProt21874239 details
PROF1_HUMANESR1_HUMANBioGRID, IntAct23576398 details
PROF1_HUMANVASP_HUMANBioGRID, HPRD, IntAct10882740 32814053 34079125 details
PROF1_HUMANAFAD_HUMANBioGRID10922060 details
PROF1_HUMANLRIF1_HUMANBioGRID, HPRD16169070 details
PROF1_HUMANRHOQ_HUMANBioGRID, HPRD10445846 details
PROF1_HUMANVIPR1_HUMANBioGRID10867004 details
PROF1_HUMANWASL_HUMANBioGRID, HPRD10867004 9822597 details
PROF1_HUMANFMNL1_HUMANBioGRID, HPRD10958683 details
PROF1_HUMANENAH_HUMANBioGRID, HPRD34079125 9473484 details
PROF1_HUMANGEPH_HUMANBioGRID, HPRD34079125 9473484 details
PROF1_HUMANNCK1_HUMANBioGRID9694849 details
PROF1_HUMAN1433T_HUMANBioGRID15161933 details
PROF1_HUMANCHIP_HUMANBioGRID24661873 details
PROF1_HUMANTRI15_HUMANBioGRID25450970 details
PROF1_HUMANTRAF6_HUMANBioGRID28024152 details
PROF1_HUMANSHPS1_HUMANBioGRID19299420 details
PROF1_HUMANAB1IP_HUMANHPRD15469846 details
PROF1_HUMANMYPOP_HUMANHPRD15615774 details
PROF1_HUMANRIF1_HUMANIntAct16169070 details
PROF1_HUMAN1433Z_HUMANMINT15161933 details
PROF1_HUMANXPO6_HUMANBioGRID, HPRD14592989 details
PROF1_HUMANITA4_HUMANBioGRID22623428 details
PROF1_HUMANPTEN_HUMANBioGRID26787927 details
PROF1_HUMANATG5_HUMANBioGRID33024031 details
PROF1_HUMANP85A_HUMANHPRD9801792 details
PROF1_HUMANDYN2_HUMANHPRD12419186 details
PROF1_HUMANWIPF2_HUMANHPRD12213210 details
PROF1_HUMANCMA1_HUMANHPRD11751973 details
PROF1_HUMANACTS_HUMANHPRD8413665 details
PROF1_HUMANDREB_HUMANHPRD9473484 details