Entity Details

Primary name LYN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07948
EntryNameLYN_HUMAN
FullNameTyrosine-protein kinase Lyn
TaxID9606
Evidenceevidence at protein level
Length512
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesLYN

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0001817 regulation of cytokine production
GO:0001932 regulation of protein phosphorylation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002513 tolerance induction to self antigen
GO:0002553 histamine secretion by mast cell
GO:0002576 platelet degranulation
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002774 Fc receptor mediated inhibitory signaling pathway
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0002902 regulation of B cell apoptotic process
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005161 platelet-derived growth factor receptor binding
GO:0005178 integrin binding
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005758 mitochondrial intermembrane space
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0006991 response to sterol depletion
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell population proliferation
GO:0008285 negative regulation of cell population proliferation
GO:0009636 response to toxic substance
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0010976 positive regulation of neuron projection development
GO:0014003 oligodendrocyte development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014069 postsynaptic density
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016301 kinase activity
GO:0017124 SH3 domain binding
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019899 enzyme binding
GO:0030061 mitochondrial crista
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030218 erythrocyte differentiation
GO:0030335 positive regulation of cell migration
GO:0030889 negative regulation of B cell proliferation
GO:0031175 neuron projection development
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031295 T cell costimulation
GO:0031625 ubiquitin protein ligase binding
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0032868 response to insulin
GO:0033003 regulation of mast cell activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034605 cellular response to heat
GO:0034666 integrin alpha2-beta1 complex
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043015 gamma-tubulin binding
GO:0043200 response to amino acid
GO:0043208 glycosphingolipid binding
GO:0043231 intracellular membrane-bounded organelle
GO:0043304 regulation of mast cell degranulation
GO:0043407 negative regulation of MAP kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0044325 transmembrane transporter binding
GO:0045087 innate immune response
GO:0045121 membrane raft
GO:0045646 regulation of erythrocyte differentiation
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046777 protein autophosphorylation
GO:0046875 ephrin receptor binding
GO:0048013 ephrin receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048678 response to axon injury
GO:0050777 negative regulation of immune response
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051219 phosphoprotein binding
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0060252 positive regulation of glial cell proliferation
GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT
GO:0070062 extracellular exosome
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070447 positive regulation of oligodendrocyte progenitor proliferation
GO:0070667 negative regulation of mast cell proliferation
GO:0070668 positive regulation of mast cell proliferation
GO:0071300 cellular response to retinoic acid
GO:0090025 regulation of monocyte chemotaxis
GO:0090330 regulation of platelet aggregation
GO:0097028 dendritic cell differentiation
GO:0098978 glutamatergic synapse
GO:0099091 postsynaptic specialization, intracellular component
GO:0140031 phosphorylation-dependent protein binding
GO:1902532 negative regulation of intracellular signal transduction
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:2000670 positive regulation of dendritic cell apoptotic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Golgi apparatus
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035748 Tyrosine-protein kinase Lyn, SH3 domainDomainDomain
IPR035852 Tyrosine-protein kinase Lyn, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-YlamineDrugbanksmall molecule
DB06616 BosutinibDrugbanksmall molecule
DB08901 PonatinibDrugbanksmall molecule
DB09079 NintedanibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule

Interactions

177 interactions

InteractorPartnerSourcesPublicationsLink
LYN_HUMANFAK1_HUMANBioGRID, IntAct, MINT11389892 25814554 9169439 details
LYN_HUMANSHC1_HUMANBioGRID, HPRD, MINT7516469 7650013 details
LYN_HUMANKHDR1_HUMANBioGRID, HPRD, IntAct, MINT15190072 22745667 7516469 9045636 details
LYN_HUMANCBL_HUMANBioGRID, HPRD, MINT12149655 12244174 15190072 18235045 7721825 7782294 8621719 9160881 details
LYN_HUMANCD22_HUMANBioGRID, HPRD, IntAct10228003 10748054 8647200 details
LYN_HUMANCSK2B_HUMANBioGRID, HPRD, IntAct14667819 details
LYN_HUMANCIP4_HUMANHPRD, MINT12456510 details
LYN_HUMANGPVI_HUMANBioGRID, DIP, HPRD, IntAct11943772 12594225 1715582 19940238 20946164 details
LYN_HUMANLYN_HUMANBioGRID, HPRD, IntAct11157475 11744621 11943772 14993658 31980649 9171348 details
LYN_HUMANPAK2_HUMANHPRD, MINT16374509 details
LYN_HUMANADA15_HUMANBioGRID, HPRD, MINT, UniProt16374509 25825872 details
LYN_HUMANSPHK2_HUMANHPRD, IntAct16316995 details
LYN_HUMANEGFR_HUMANBioGRID, HPRD, IntAct, Molecular Connections16799092 22973453 23764002 23866081 24658140 25402006 31980649 34079125 details
LYN_HUMANCDN1B_HUMANBioGRID, HPRD, IntAct17254966 details
LYN_HUMANTNFL6_HUMANBioGRID, IntAct17164290 19807924 details
LYN_HUMANITB1_HUMANBioGRID, IntAct, mbinfo14593208 20159608 34079125 details
LYN_HUMANABI1_HUMANBioGRID, MINT20598684 34079125 details
LYN_HUMANFCG2B_HUMANBioGRID, HPRD, MINT10382761 8756631 9232445 details
LYN_HUMANPHAG1_HUMANBioGRID, HPRD, MINT, Molecular Connections10790433 18070987 23866081 34079125 details
LYN_HUMANSTAT3_HUMANBioGRID, MINT12244095 18070987 details
LYN_HUMANSRC_HUMANBioGRID, InnateDB, MINT18070987 22581261 9169421 details
LYN_HUMANCENPV_HUMANBioGRID, MINT19930468 details
LYN_HUMANUHRF2_HUMANBioGRID, UniProt21952639 details
LYN_HUMANITB3_HUMANmbinfo14593208 details
LYN_HUMANITB2_HUMANmbinfo14593208 details
LYN_HUMANPTN6_HUMANBioGRID, HPRD, IntAct10488096 10574931 10871605 11042209 12468540 22624718 8114715 8692915 details
LYN_HUMANMCM7_HUMANIntAct23764002 details
LYN_HUMANANDR_HUMANBioGRID, IntAct24728074 details
LYN_HUMANGAB1_HUMANBioGRID, IntAct24728074 34079125 details
LYN_HUMANKIT_HUMANBioGRID, HPRD, IntAct11825908 24728074 9341198 details
LYN_HUMANMET_HUMANBioGRID, IntAct24728074 34079125 details
LYN_HUMANADAM9_HUMANUniProt25825872 details
LYN_HUMANADA12_HUMANUniProt25825872 details
LYN_HUMANADA19_HUMANUniProt25825872 details
LYN_HUMANTRI63_HUMANBioGRID, IntAct31391242 details
LYN_HUMANTRI55_HUMANBioGRID, IntAct31391242 details
LYN_HUMANCDK1_HUMANBioGRID, HPRD, IntAct10564259 31980649 8051175 8084605 8910336 details
LYN_HUMANA2MG_HUMANIntAct32814053 details
LYN_HUMANDYN2_HUMANIntAct32814053 details
LYN_HUMANPGCB_HUMANIntAct32814053 details
LYN_HUMANMARK4_HUMANIntAct32814053 details
LYN_HUMANERP44_HUMANIntAct32814053 details
LYN_HUMANSAP_HUMANIntAct32814053 details
LYN_HUMANP85A_HUMANBioGRID, IntAct32814053 34079125 details
LYN_HUMANMECP2_HUMANIntAct32814053 details
LYN_HUMANSPRE1_HUMANIntAct32814053 details
LYN_HUMANA4_HUMANIntAct32814053 details
LYN_HUMANSYUA_HUMANHPRD, IntAct11162638 11744621 12096713 32814053 details
LYN_HUMANBANK1_HUMANBioGRID, HPRD, UniProt11782428 details
LYN_HUMANMUC1_HUMANBioGRID, HPRD12750561 details
LYN_HUMANSHIP1_HUMANBioGRID, HPRD12882960 details
LYN_HUMANPDE4A_HUMANBioGRID, HPRD10206997 12810716 details
LYN_HUMANU119A_HUMANBioGRID, HPRD12496276 details
LYN_HUMANDOK1_HUMANBioGRID, HPRD11071635 11825908 details
LYN_HUMANKSYK_HUMANBioGRID, HPRD11536198 7831290 8621719 9820500 details
LYN_HUMANNEP_HUMANBioGRID, HPRD11104793 8943850 details
LYN_HUMANCASL_HUMANBioGRID, HPRD9020138 details
LYN_HUMANPLCG2_HUMANBioGRID, HPRD10981967 12181444 15144186 7682059 8395016 details
LYN_HUMANLCP2_HUMANBioGRID, HPRD10026222 details
LYN_HUMANGAB3_HUMANBioGRID, HPRD11739737 18235045 details
LYN_HUMANJAK2_HUMANBioGRID, HPRD9573010 details
LYN_HUMANEPOR_HUMANBioGRID, HPRD9573010 details
LYN_HUMANSKAP2_HUMANBioGRID, HPRD29568343 9837776 details
LYN_HUMANKS6B1_HUMANBioGRID16640565 details
LYN_HUMANKS6B2_HUMANBioGRID16640565 details
LYN_HUMANSKAP1_HUMANBioGRID, HPRD9195899 details
LYN_HUMANIL3RB_HUMANBioGRID, HPRD7636265 9973406 details
LYN_HUMANBTK_HUMANBioGRID, HPRD11226282 11598012 8058772 8629002 8630736 details
LYN_HUMANPRKDC_HUMANBioGRID, HPRD9748231 details
LYN_HUMANEVL_HUMANBioGRID, HPRD10945997 details
LYN_HUMANPR15A_HUMANBioGRID, HPRD11517336 details
LYN_HUMANTRAT1_HUMANBioGRID, HPRD10790433 9687533 details
LYN_HUMANNMT1_HUMANBioGRID, HPRD11594778 details
LYN_HUMANTYK2_HUMANBioGRID, HPRD9633884 details
LYN_HUMANCD72_HUMANBioGRID9590210 details
LYN_HUMANRL10_HUMANBioGRID12138090 details
LYN_HUMANPP1R8_HUMANBioGRID, HPRD11104670 details
LYN_HUMANPK3CG_HUMANBioGRID, HPRD10318860 7721825 details
LYN_HUMANPTPRC_HUMANBioGRID, HPRD10415030 12393728 7516335 details
LYN_HUMANCBLC_HUMANBioGRID, HPRD10362357 details
LYN_HUMANTRPV4_HUMANBioGRID, HPRD12538589 details
LYN_HUMANNFIP2_HUMANBioGRID20534535 details
LYN_HUMANCBP_HUMANBioGRID22364282 details
LYN_HUMANACK1_HUMANBioGRID21309750 details
LYN_HUMANPDE4D_HUMANBioGRID10571082 details
LYN_HUMANTNFA_HUMANBioGRID9230816 details
LYN_HUMANIL1B_HUMANBioGRID9230816 details
LYN_HUMANRGS16_HUMANBioGRID, HPRD11602604 12588871 details
LYN_HUMANTIF1B_HUMANBioGRID23645696 details
LYN_HUMANCD19_HUMANBioGRID, HPRD10933394 15187135 7568175 7589101 details
LYN_HUMANCOASY_HUMANBioGRID19763791 details
LYN_HUMANERBB2_HUMANBioGRID22973453 34079125 details
LYN_HUMANERBB3_HUMANBioGRID22973453 details
LYN_HUMANERBB4_HUMANBioGRID22973453 details
LYN_HUMANSOCS1_HUMANBioGRID31101761 details
LYN_HUMANTMG4_HUMANBioGRID23873930 details
LYN_HUMANM3K3_HUMANIntAct14743216 details
LYN_HUMANHCLS1_HUMANBioGRID, HPRD, MINT10066823 15795233 7682714 9104825 details
LYN_HUMANITA4_HUMANIntAct20159608 details
LYN_HUMANCD37_HUMANIntAct22624718 details
LYN_HUMANCD24_HUMANBioGRID, HPRD, Molecular Connections22731636 8753773 details
LYN_HUMANMK03_HUMANBioGRID, HPRD, Molecular Connections11131153 22731636 details
LYN_HUMANDOCK8_HUMANInnateDB22581261 details
LYN_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
LYN_HUMANRACK1_HUMANMolecular Connections23866081 details
LYN_HUMANCD36_HUMANBioGRID, HPRD, IntAct1715582 20037584 details
LYN_HUMANSCIMP_HUMANBioGRID, UniProt21930792 23503679 details
LYN_HUMANHS90A_HUMANBioGRID, IntAct22939624 27742708 31980649 details
LYN_HUMANPRAM_HUMANBioGRID, HPRD11301322 details
LYN_HUMANGAB2_HUMANBioGRID, HPRD11971018 details
LYN_HUMANTEC_HUMANBioGRID, HPRD11071635 8621063 9446655 details
LYN_HUMANFAK2_HUMANBioGRID, HPRD11311138 details
LYN_HUMANBCAR1_HUMANBioGRID, HPRD9020138 9581808 details
LYN_HUMANFCG2A_HUMANBioGRID, HPRD8756631 9268059 details
LYN_HUMANPECA1_HUMANBioGRID, HPRD10858437 details
LYN_HUMANCTLA4_HUMANBioGRID, HPRD9712716 details
LYN_HUMANCSF3R_HUMANBioGRID, HPRD8197119 details
LYN_HUMANCSF1R_HUMANBioGRID, HPRD7636265 details
LYN_HUMANCDK2_HUMANBioGRID, HPRD10432313 8806683 details
LYN_HUMANFCAR_HUMANBioGRID, HPRD9427690 details
LYN_HUMANBLNK_HUMANBioGRID21822214 details
LYN_HUMANSH3K1_HUMANBioGRID15707590 details
LYN_HUMANFGFR2_HUMANBioGRID15190072 details
LYN_HUMANP53_HUMANBioGRID12642697 details
LYN_HUMANGP1BB_HUMANBioGRID20946164 details
LYN_HUMANACSL3_HUMANBioGRID20605918 details
LYN_HUMANSVIL_HUMANBioGRID12202484 details
LYN_HUMANSH21A_HUMANBioGRID23503679 details
LYN_HUMANANR54_HUMANBioGRID23503679 details
LYN_HUMANHNRPK_HUMANBioGRID, HPRD23503679 7516469 details
LYN_HUMANKHDR2_HUMANBioGRID23503679 details
LYN_HUMANLNP1_HUMANBioGRID23503679 details
LYN_HUMANP55G_HUMANBioGRID23503679 details
LYN_HUMANSH24A_HUMANBioGRID23503679 details
LYN_HUMANNEMO_HUMANBioGRID23131831 details
LYN_HUMANABCE1_HUMANBioGRID25659154 details
LYN_HUMANBCAP_HUMANBioGRID27909057 details
LYN_HUMANGP1BA_HUMANBioGRID12393736 details
LYN_HUMANFLT3_HUMANBioGRID16684964 details
LYN_HUMANIL1R1_HUMANBioGRID7499252 details
LYN_HUMANVP13A_HUMANBioGRID27742708 34079125 details
LYN_HUMANATG7_HUMANBioGRID27742708 details
LYN_HUMANULK1_HUMANBioGRID27742708 details
LYN_HUMANPLCG1_HUMANHPRD10586033 15144186 1689310 7682059 8657103 8885868 details
LYN_HUMANKPCD_HUMANHPRD10945993 7575560 details
LYN_HUMANGRIA3_HUMANHPRD9892356 details
LYN_HUMANMATK_HUMANHPRD1722201 9171348 details
LYN_HUMANKPCT_HUMANHPRD11358993 details
LYN_HUMANCASP3_HUMANHPRD11526478 details
LYN_HUMANM4K1_HUMANHPRD11514608 details
LYN_HUMANNPHN_HUMANHPRD12846735 details
LYN_HUMANDLG4_HUMANHPRD9892651 details
LYN_HUMANCHSTF_HUMANHPRD10749872 details
LYN_HUMANSH2B2_HUMANHPRD10872802 details
LYN_HUMANDOK3_HUMANHPRD10733577 details
LYN_HUMANB3AT_HUMANHPRD10942405 16118313 1998697 2065070 details
LYN_HUMANCD79A_HUMANHPRD9531288 details
LYN_HUMANDAPP1_HUMANHPRD11524430 details
LYN_HUMANCSF2R_HUMANHPRD8943427 details
LYN_HUMANRASA1_HUMANHPRD8395016 details
LYN_HUMANIL2RB_HUMANHPRD1557373 details
LYN_HUMANITPR1_HUMANHPRD11782428 details
LYN_HUMANCASP7_HUMANHPRD12586738 details
LYN_HUMANCRKL_HUMANHPRD11443118 details
LYN_HUMANCASP9_HUMANHPRD12586738 details
LYN_HUMANLIME1_HUMANHPRD16249387 details
LYN_HUMANPILRB_HUMANHPRD10327049 details
LYN_HUMANUBB_HUMANHPRD11046148 details
LYN_HUMANCSK_HUMANHPRD8612628 details
LYN_HUMANCD20_HUMANHPRD7545683 details
LYN_HUMANACTB_HUMANHPRD10403844 details
LYN_HUMANDOK2_HUMANHPRD10428862 details
LYN_HUMANSPHK1_HUMANHPRD16316995 details
LYN_HUMANIL7RA_HUMANHPRD7515933 details
LYN_HUMANFCERB_HUMANHPRD19356729 7528770 7612892 details
LYN_HUMANFCERG_HUMANHPRD11388899 details
LYN_HUMANCD79B_HUMANHPRD9531288 details