Entity Details

Primary name TSP1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP07996
EntryNameTSP1_HUMAN
FullNameThrombospondin-1
TaxID9606
Evidenceevidence at protein level
Length1170
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesTHBS1

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001666 response to hypoxia
GO:0001786 phosphatidylserine binding
GO:0001937 negative regulation of endothelial cell proliferation
GO:0001953 negative regulation of cell-matrix adhesion
GO:0001968 fibronectin binding
GO:0002040 sprouting angiogenesis
GO:0002544 chronic inflammatory response
GO:0002576 platelet degranulation
GO:0002581 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 negative regulation of dendritic cell antigen processing and presentation
GO:0005178 integrin binding
GO:0005201 extracellular matrix structural constituent
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0006986 response to unfolded protein
GO:0007155 cell adhesion
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0010595 positive regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010748 negative regulation of long-chain fatty acid import across plasma membrane
GO:0010751 negative regulation of nitric oxide mediated signal transduction
GO:0010754 negative regulation of cGMP-mediated signaling
GO:0010757 negative regulation of plasminogen activation
GO:0010759 positive regulation of macrophage chemotaxis
GO:0010763 positive regulation of fibroblast migration
GO:0016477 cell migration
GO:0016525 negative regulation of angiogenesis
GO:0016529 sarcoplasmic reticulum
GO:0017134 fibroblast growth factor binding
GO:0018149 peptide cross-linking
GO:0030141 secretory granule
GO:0030169 low-density lipoprotein particle binding
GO:0030194 positive regulation of blood coagulation
GO:0030198 extracellular matrix organization
GO:0030335 positive regulation of cell migration
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0031012 extracellular matrix
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0032026 response to magnesium ion
GO:0032570 response to progesterone
GO:0032695 negative regulation of interleukin-12 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032914 positive regulation of transforming growth factor beta1 production
GO:0033574 response to testosterone
GO:0034605 cellular response to heat
GO:0034976 response to endoplasmic reticulum stress
GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0042493 response to drug
GO:0042802 identical protein binding
GO:0043032 positive regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043236 laminin binding
GO:0043394 proteoglycan binding
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043652 engulfment of apoptotic cell
GO:0045652 regulation of megakaryocyte differentiation
GO:0045727 positive regulation of translation
GO:0045766 positive regulation of angiogenesis
GO:0048266 behavioral response to pain
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050431 transforming growth factor beta binding
GO:0050921 positive regulation of chemotaxis
GO:0051592 response to calcium ion
GO:0051895 negative regulation of focal adhesion assembly
GO:0051897 positive regulation of protein kinase B signaling
GO:0051918 negative regulation of fibrinolysis
GO:0062023 collagen-containing extracellular matrix
GO:0070051 fibrinogen binding
GO:0070052 collagen V binding
GO:0070062 extracellular exosome
GO:0071356 cellular response to tumor necrosis factor
GO:0071363 cellular response to growth factor stimulus
GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903671 negative regulation of sprouting angiogenesis
GO:2000353 positive regulation of endothelial cell apoptotic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001027 negative regulation of endothelial cell chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Cell surface
Endoplasmic reticulum
Sarcoplasmic reticulum
Secreted

Domains

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DomainNameCategoryType
IPR000742 EGF-like domainDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR001007 VWFC domainDomainDomain
IPR001791 Laminin G domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR003367 Thrombospondin, type 3-like repeatRepeatRepeat
IPR008859 Thrombospondin, C-terminalDomainDomain
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017897 Thrombospondin, type 3 repeatRepeatRepeat
IPR028499 Thrombospondin-1FamilyFamily
IPR028974 TSP type-3 repeatFamilyHomologous superfamily
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily

Diseases

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Interactions

47 interactions

InteractorPartnerSourcesPublicationsLink
TSP1_HUMANTGM2_HUMANIntAct19542224 details
TSP1_HUMANFINC_HUMANHPRD, IntAct11773026 18042364 19542224 details
TSP1_HUMANTGFB1_HUMANBioGRID, HPRD, UniProt1550960 15864306 details
TSP1_HUMANPCOC1_HUMANmatrixdb24117177 details
TSP1_HUMANLRP1_HUMANBioGRID, HPRD14991768 7775583 9045712 details
TSP1_HUMANIBP5_HUMANBioGRID, HPRD10698186 details
TSP1_HUMANPLMN_HUMANBioGRID, HPRD2522013 6438154 details
TSP1_HUMANCO3A1_HUMANBioGRID, HPRD3571333 details
TSP1_HUMANCO2A1_HUMANBioGRID, HPRD3571333 details
TSP1_HUMANCO1A1_HUMANBioGRID, HPRD3571333 details
TSP1_HUMANCO4A1_HUMANBioGRID3571333 details
TSP1_HUMANCO5A1_HUMANBioGRID, HPRD3571333 6693501 9840442 details
TSP1_HUMANCALCR_HUMANBioGRID12147682 details
TSP1_HUMANTFPI1_HUMANBioGRID, HPRD10922378 details
TSP1_HUMANITB3_HUMANBioGRID, HPRD14963009 2478219 details
TSP1_HUMANTHRB_HUMANBioGRID, HPRD2435757 details
TSP1_HUMANLRP2_HUMANBioGRID7775583 details
TSP1_HUMANPDGFB_HUMANBioGRID, HPRD9334164 details
TSP1_HUMANSCRB2_HUMANBioGRID, HPRD9478926 details
TSP1_HUMANELNE_HUMANBioGRID, HPRD8463250 details
TSP1_HUMANFIBA_HUMANBioGRID, HPRD9867861 details
TSP1_HUMANCO7A1_HUMANBioGRID, HPRD9840442 details
TSP1_HUMANMMP2_HUMANBioGRID, HPRD10900205 details
TSP1_HUMANMMP9_HUMANBioGRID, HPRD10900205 11606713 details
TSP1_HUMANFGF2_HUMANBioGRID17996481 details
TSP1_HUMANHS90A_HUMANBioGRID31273033 details
TSP1_HUMANJAG1_HUMANHPRD15258909 details
TSP1_HUMANLAMB3_HUMANHPRD9840442 details
TSP1_HUMANTSG6_HUMANHPRD, IntAct16006654 18042364 details
TSP1_HUMANVEGFA_HUMANDIP19805200 details
TSP1_HUMANHTRA1_HUMANIntAct29572155 details
TSP1_HUMANPSMD4_HUMANBioGRID15095410 details
TSP1_HUMANITAV_HUMANBioGRID14963009 details
TSP1_HUMANITB1_HUMANBioGRID14963009 details
TSP1_HUMANCD36_HUMANHPRD10487979 10772961 details
TSP1_HUMANSPRC_HUMANHPRD2745554 details
TSP1_HUMANKNG1_HUMANHPRD9459346 details
TSP1_HUMANCD47_HUMANHPRD10397731 8550562 9169439 details
TSP1_HUMANLRP5_HUMANHPRD7775583 details
TSP1_HUMANCOR1A_HUMANHPRD10749676 details
TSP1_HUMANCALR_HUMANHPRD12147682 details
TSP1_HUMANCATG_HUMANHPRD8408036 details
TSP1_HUMANCFAH_HUMANHPRD15634279 details
TSP1_HUMANTR11B_HUMANHPRD15799029 details
TSP1_HUMANPGS2_HUMANHPRD1550960 9328841 details
TSP1_HUMANDYR_HUMANHPRD10749676 details
TSP1_HUMANHRG_HUMANHPRD6438154 details