Entity Details

Primary name ADRB1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP08588
EntryNameADRB1_HUMAN
FullNameBeta-1 adrenergic receptor
TaxID9606
Evidenceevidence at protein level
Length477
SequenceStatuscomplete
DateCreated1988-08-01
DateModified2021-06-02

Ontological Relatives

GenesADRB1

GO terms

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GOName
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0002024 diet induced thermogenesis
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004939 beta-adrenergic receptor activity
GO:0004940 beta1-adrenergic receptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005769 early endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0009409 response to cold
GO:0030165 PDZ domain binding
GO:0031649 heat generation
GO:0031694 alpha-2A adrenergic receptor binding
GO:0040015 negative regulation of multicellular organism growth
GO:0042596 fear response
GO:0043547 positive regulation of GTPase activity
GO:0045187 regulation of circadian sleep/wake cycle, sleep
GO:0046982 protein heterodimerization activity
GO:0050873 brown fat cell differentiation
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0098685 Schaffer collateral - CA1 synapse
GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
GO:0120162 positive regulation of cold-induced thermogenesis

Subcellular Location

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Subcellular Location
Cell membrane
Early endosome

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000507 Beta 1 adrenoceptorFamilyFamily
IPR002233 Adrenoceptor familyFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00127 SpermineDrugbanksmall molecule
DB00182 AmphetamineDrugbanksmall molecule
DB00187 EsmololDrugbanksmall molecule
DB00195 BetaxololDrugbanksmall molecule
DB00217 BethanidineDrugbanksmall molecule
DB00221 IsoetharineDrugbanksmall molecule
DB00243 RanolazineDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00264 MetoprololDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00335 AtenololDrugbanksmall molecule
DB00368 NorepinephrineDrugbanksmall molecule
DB00373 TimololDrugbanksmall molecule
DB00397 PhenylpropanolamineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00489 SotalolDrugbanksmall molecule
DB00521 CarteololDrugbanksmall molecule
DB00540 NortriptylineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00571 PropranololDrugbanksmall molecule
DB00598 LabetalolDrugbanksmall molecule
DB00612 BisoprololDrugbanksmall molecule
DB00668 EpinephrineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00785 CryptenamineDrugbanksmall molecule
DB00841 DobutamineDrugbanksmall molecule
DB00852 PseudoephedrineDrugbanksmall molecule
DB00866 AlprenololDrugbanksmall molecule
DB00871 TerbutalineDrugbanksmall molecule
DB00938 SalmeterolDrugbanksmall molecule
DB00960 PindololDrugbanksmall molecule
DB00983 FormoterolDrugbanksmall molecule
DB01001 SalbutamolDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01064 IsoprenalineDrugbanksmall molecule
DB01102 ArbutamineDrugbanksmall molecule
DB01118 AmiodaroneDrugbanksmall molecule
DB01136 CarvedilolDrugbanksmall molecule
DB01151 DesipramineDrugbanksmall molecule
DB01182 PropafenoneDrugbanksmall molecule
DB01193 AcebutololDrugbanksmall molecule
DB01203 NadololDrugbanksmall molecule
DB01210 LevobunololDrugbanksmall molecule
DB01214 MetipranololDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01288 FenoterolDrugbanksmall molecule
DB01291 PirbuterolDrugbanksmall molecule
DB01295 BevantololDrugbanksmall molecule
DB01297 PractololDrugbanksmall molecule
DB01359 PenbutololDrugbanksmall molecule
DB01363 Ephedra sinica rootDrugbankbiotech
DB01364 EphedrineDrugbanksmall molecule
DB01365 MephentermineDrugbanksmall molecule
DB01407 ClenbuterolDrugbanksmall molecule
DB01580 OxprenololDrugbanksmall molecule
DB01917 PutrescineDrugbanksmall molecule
DB03566 SpermidineDrugbanksmall molecule
DB04846 CeliprololDrugbanksmall molecule
DB04855 DronedaroneDrugbanksmall molecule
DB04861 NebivololDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB06262 DroxidopaDrugbanksmall molecule
DB06726 BufuralolDrugbanksmall molecule
DB08347 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrileDrugbanksmall molecule
DB08558 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOLDrugbanksmall molecule
DB08807 BopindololDrugbanksmall molecule
DB08808 BupranololDrugbanksmall molecule
DB09013 BefunololDrugbanksmall molecule
DB09068 VortioxetineDrugbanksmall molecule
DB09204 ArotinololDrugbanksmall molecule
DB09351 LevobetaxololDrugbanksmall molecule
DB11124 RacepinephrineDrugbanksmall molecule
DB11273 DihydroergocornineDrugbanksmall molecule
DB11278 DL-MethylephedrineDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB13781 XamoterolDrugbanksmall molecule