Entity Details

Primary name E2F8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA0AVK6
EntryNameE2F8_HUMAN
FullNameTranscription factor E2F8
TaxID9606
Evidenceevidence at protein level
Length867
SequenceStatuscomplete
DateCreated2007-08-21
DateModified2021-06-02

Ontological Relatives

GenesE2F8

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001890 placenta development
GO:0002040 sprouting angiogenesis
GO:0003700 DNA-binding transcription factor activity
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0008283 cell population proliferation
GO:0032466 negative regulation of cytokinesis
GO:0032877 positive regulation of DNA endoreduplication
GO:0033301 cell cycle comprising mitosis without cytokinesis
GO:0042802 identical protein binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0060707 trophoblast giant cell differentiation
GO:0060718 chorionic trophoblast cell differentiation
GO:0070365 hepatocyte differentiation
GO:0090575 RNA polymerase II transcription regulator complex
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR003316 E2F/DP family, winged-helix DNA-binding domainDomainDomain
IPR015633 E2F FamilyFamilyFamily
IPR036388 Winged helix-like DNA-binding domain superfamilyFamilyHomologous superfamily
IPR036390 Winged helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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