Entity Details

Primary name CATH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09668
EntryNameCATH_HUMAN
FullNamePro-cathepsin H
TaxID9606
Evidenceevidence at protein level
Length335
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesCTSH

GO terms

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GOName
GO:0001656 metanephros development
GO:0001913 T cell mediated cytotoxicity
GO:0002250 adaptive immune response
GO:0002764 immune response-regulating signaling pathway
GO:0004175 endopeptidase activity
GO:0004177 aminopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
GO:0005829 cytosol
GO:0006508 proteolysis
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0008284 positive regulation of cell population proliferation
GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0010813 neuropeptide catabolic process
GO:0010815 bradykinin catabolic process
GO:0010952 positive regulation of peptidase activity
GO:0019882 antigen processing and presentation
GO:0030108 HLA-A specific activating MHC class I receptor activity
GO:0030335 positive regulation of cell migration
GO:0031638 zymogen activation
GO:0031648 protein destabilization
GO:0032526 response to retinoic acid
GO:0033619 membrane protein proteolysis
GO:0034774 secretory granule lumen
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043066 negative regulation of apoptotic process
GO:0043129 surfactant homeostasis
GO:0043231 intracellular membrane-bounded organelle
GO:0043312 neutrophil degranulation
GO:0044267 cellular protein metabolic process
GO:0045766 positive regulation of angiogenesis
GO:0051603 proteolysis involved in cellular protein catabolic process
GO:0060448 dichotomous subdivision of terminal units involved in lung branching
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0070324 thyroid hormone binding
GO:0070371 ERK1 and ERK2 cascade
GO:0097067 cellular response to thyroid hormone stimulus
GO:0097208 alveolar lamellar body
GO:0097486 multivesicular body lumen
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Lysosome

Domains

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DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR000668 Peptidase C1A, papain C-terminalDomainDomain
IPR013201 Cathepsin propeptide inhibitor domain (I29)DomainDomain
IPR025660 Cysteine peptidase, histidine active siteSiteActive site
IPR025661 Cysteine peptidase, asparagine active siteSiteActive site
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily
IPR039417 Papain-like cysteine endopeptidaseDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB02140 N1-(1-Dimethylcarbamoyl-2-Phenyl-Ethyl)-2-Oxo-N4-(2-Pyridin-2-Yl-Ethyl)-SuccinamideDrugbanksmall molecule
DB03120 p-Toluenesulfonic acidDrugbanksmall molecule
DB04126 N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-ButaneDrugbanksmall molecule
DB08526 CARBOBENZYLOXY-(L)-LEUCINYL-(L)LEUCINYL METHOXYMETHYLKETONEDrugbanksmall molecule