Entity Details

Primary name FGR_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP09769
EntryNameFGR_HUMAN
FullNameTyrosine-protein kinase Fgr
TaxID9606
Evidenceevidence at protein level
Length529
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesFGR

GO terms

Show/Hide Table
GOName
GO:0001784 phosphotyrosine residue binding
GO:0001819 positive regulation of cytokine production
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005102 signaling receptor binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005743 mitochondrial inner membrane
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0008360 regulation of cell shape
GO:0009615 response to virus
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015629 actin cytoskeleton
GO:0016235 aggresome
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019901 protein kinase binding
GO:0030154 cell differentiation
GO:0030282 bone mineralization
GO:0030335 positive regulation of cell migration
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0032587 ruffle membrane
GO:0032815 negative regulation of natural killer cell activation
GO:0034774 secretory granule lumen
GO:0034987 immunoglobulin receptor binding
GO:0034988 Fc-gamma receptor I complex binding
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043306 positive regulation of mast cell degranulation
GO:0043312 neutrophil degranulation
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087 innate immune response
GO:0045088 regulation of innate immune response
GO:0045859 regulation of protein kinase activity
GO:0046777 protein autophosphorylation
GO:0048705 skeletal system morphogenesis
GO:0050764 regulation of phagocytosis
GO:0050830 defense response to Gram-positive bacterium
GO:0070062 extracellular exosome

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Mitochondrion inner membrane
Mitochondrion intermembrane space

Domains

Show/Hide Table
DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035693 Tyrosine-protein kinase Fgr, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01254 DasatinibDrugbanksmall molecule
DB12010 FostamatinibDrugbanksmall molecule
DB15035 ZanubrutinibDrugbanksmall molecule

Interactions

38 interactions

InteractorPartnerSourcesPublicationsLink
FGR_HUMANWASP_HUMANBioGRID, HPRD, MINT10358777 7565724 8805332 8824280 details
FGR_HUMANKSYK_HUMANBioGRID, HPRD, MINT11672534 15536084 details
FGR_HUMANERBB2_HUMANBioGRID, MINT16273093 22973453 details
FGR_HUMANABI1_HUMANMINT20598684 details
FGR_HUMANNR1I2_HUMANBioGRID, IntAct21988832 details
FGR_HUMANSTAT3_HUMANBioGRID, IntAct12244095 21988832 details
FGR_HUMANLOX5_HUMANMINT24860872 details
FGR_HUMANANDR_HUMANBioGRID, IntAct24728074 details
FGR_HUMANKIT_HUMANBioGRID, IntAct24728074 details
FGR_HUMANMET_HUMANBioGRID, IntAct24728074 details
FGR_HUMANEGFR_HUMANBioGRID, IntAct24658140 25402006 31980649 details
FGR_HUMANDOK1_HUMANBioGRID, HPRD11071635 22974441 details
FGR_HUMANHCLS1_HUMANBioGRID, HPRD10066823 details
FGR_HUMANDAB2_HUMANBioGRID, HPRD12473651 details
FGR_HUMANTNFL6_HUMANBioGRID17164290 details
FGR_HUMANNEMO_HUMANBioGRID20098747 23131831 details
FGR_HUMANKHDR1_HUMANBioGRID15190072 22745667 details
FGR_HUMANSMUF1_HUMANBioGRID20804422 details
FGR_HUMANSKAP2_HUMANBioGRID29568343 details
FGR_HUMANERBB3_HUMANBioGRID22973453 details
FGR_HUMANERBB4_HUMANBioGRID22973453 details
FGR_HUMANVDR_HUMANHPRD15919723 details
FGR_HUMANHS90B_HUMANBioGRID, IntAct22939624 31980649 details
FGR_HUMANHS90A_HUMANBioGRID, IntAct22939624 31980649 details
FGR_HUMANCCR3_HUMANBioGRID, HPRD10527858 details
FGR_HUMANFAK1_HUMANBioGRID12387730 details
FGR_HUMANSLAF1_HUMANBioGRID, HPRD10229804 details
FGR_HUMANCBL_HUMANBioGRID, HPRD12435267 7721825 details
FGR_HUMANCD24_HUMANBioGRID, HPRD8753773 details
FGR_HUMANSH3K1_HUMANBioGRID15707590 details
FGR_HUMANFLT3_HUMANBioGRID16684964 details
FGR_HUMANFGR_HUMANBioGRID, HPRD31980649 7515063 details
FGR_HUMANSRC_HUMANHPRD12387813 12468645 7678701 9208935 details
FGR_HUMANSHIP1_HUMANHPRD10229804 details
FGR_HUMANARRB1_HUMANHPRD10973280 details
FGR_HUMANCSK_HUMANHPRD7515063 8612628 details
FGR_HUMAN1433T_HUMANHPRD10066823 details
FGR_HUMANSYUA_HUMANHPRD11162638 11744621 12096713 details