Entity Details

Primary name THIO_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP10599
EntryNameTHIO_HUMAN
FullNameThioredoxin
TaxID9606
Evidenceevidence at protein level
Length105
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesTXN

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0003723 RNA binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006662 glycerol ether metabolic process
GO:0009314 response to radiation
GO:0015035 protein-disulfide reductase activity
GO:0032148 activation of protein kinase B activity
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035590 purinergic nucleotide receptor signaling pathway
GO:0042803 protein homodimerization activity
GO:0043388 positive regulation of DNA binding
GO:0045454 cell redox homeostasis
GO:0046826 negative regulation of protein export from nucleus
GO:0047134 protein-disulfide reductase (NAD(P)) activity
GO:0051897 positive regulation of protein kinase B signaling
GO:0070062 extracellular exosome
GO:0071731 response to nitric oxide
GO:1903206 negative regulation of hydrogen peroxide-induced cell death
GO:2000170 positive regulation of peptidyl-cysteine S-nitrosylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR005746 ThioredoxinFamilyFamily
IPR013766 Thioredoxin domainDomainDomain
IPR017937 Thioredoxin, conserved siteSiteConserved site
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12695 Phenethyl IsothiocyanateDrugbanksmall molecule

Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
THIO_HUMANCSN5_HUMANBioGRID, HPRD, IntAct15480426 21145461 28270496 details
THIO_HUMANEGFR_HUMANBioGRID, IntAct15657067 20029029 24658140 31980649 details
THIO_HUMANG3P_HUMANBioGRID, IntAct17353931 32814053 details
THIO_HUMANTXNIP_HUMANBioGRID, HPRD, IntAct, UniProt10419473 10814541 16269462 16766796 17603038 19018770 19605364 21636804 21705327 23519408 23880345 24198286 24389582 28514442 32296183 32901881 details
THIO_HUMANHMGB1_HUMANMINT18996119 details
THIO_HUMANCDN1A_HUMANBioGRID, IntAct21988832 details
THIO_HUMANMLH1_HUMANBioGRID, IntAct21988832 details
THIO_HUMANMYD88_HUMANBioGRID, IntAct21988832 details
THIO_HUMANNFE2_HUMANBioGRID, IntAct21988832 details
THIO_HUMANSIAH1_HUMANBioGRID, IntAct21988832 details
THIO_HUMANDYLT1_HUMANBioGRID, IntAct21988832 details
THIO_HUMANGASP2_HUMANBioGRID, IntAct21988832 details
THIO_HUMANACTN4_HUMANBioGRID, IntAct21988832 details
THIO_HUMANM3K5_HUMANBioGRID, DIP, HPRD, IntAct10843682 11689443 12089063 15696199 17331951 17724081 19018770 19805025 20385180 21771788 23291592 25098452 29186683 29227477 9564042 details
THIO_HUMANDDT4L_HUMANBioGRID, IntAct32296183 details
THIO_HUMANSRTD3_HUMANBioGRID, IntAct32296183 details
THIO_HUMANNIF3L_HUMANBioGRID, IntAct32296183 details
THIO_HUMANFST_HUMANBioGRID, IntAct12099690 32296183 details
THIO_HUMANTX13A_HUMANBioGRID, IntAct32296183 details
THIO_HUMANNUP62_HUMANBioGRID, IntAct32296183 details
THIO_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
THIO_HUMANSPG21_HUMANBioGRID, IntAct32296183 details
THIO_HUMANACTN1_HUMANBioGRID, IntAct32296183 details
THIO_HUMANMOFA1_HUMANBioGRID, IntAct32296183 details
THIO_HUMANCASP3_HUMANDIP17606900 details
THIO_HUMANAPEX1_HUMANBioGRID, DIP, HPRD10585464 11118054 22863883 8736558 9108029 details
THIO_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
THIO_HUMANERBB4_HUMANBioGRID, IntAct31980649 details
THIO_HUMANERBB3_HUMANBioGRID, IntAct31980649 details
THIO_HUMANA2MG_HUMANIntAct32814053 details
THIO_HUMANAKT1_HUMANIntAct32814053 details
THIO_HUMANBDNF_HUMANIntAct32814053 details
THIO_HUMANDYN2_HUMANIntAct32814053 details
THIO_HUMANGFAP_HUMANIntAct32814053 details
THIO_HUMANHS90A_HUMANIntAct32814053 details
THIO_HUMANMECP2_HUMANIntAct32814053 details
THIO_HUMANNDUV2_HUMANIntAct32814053 details
THIO_HUMANLRP8_HUMANIntAct32814053 details
THIO_HUMANJPH3_HUMANIntAct32814053 details
THIO_HUMANSPRE1_HUMANIntAct32814053 details
THIO_HUMANCO1A1_HUMANBioGRID, HPRD12099690 details
THIO_HUMANNCF4_HUMANBioGRID, HPRD10397171 details
THIO_HUMANGCR_HUMANBioGRID, HPRD19570036 9915858 details
THIO_HUMANVIME_HUMANBioGRID12099690 details
THIO_HUMANP53_HUMANBioGRID19681600 details
THIO_HUMANUCHL5_HUMANBioGRID21800051 details
THIO_HUMANPTEN_HUMANBioGRID26561776 details
THIO_HUMANSRPK2_HUMANBioGRID26167880 details
THIO_HUMANANR11_HUMANBioGRID32296183 details
THIO_HUMANDNJA1_HUMANHPRD16458196 details
THIO_HUMANEIF1B_HUMANIntAct17353931 details
THIO_HUMANTRAF6_HUMANIntAct17353931 details
THIO_HUMANLFG4_HUMANIntAct17353931 details
THIO_HUMANSERB_HUMANIntAct17353931 details
THIO_HUMANFBX11_HUMANIntAct17353931 details
THIO_HUMANEIPR1_HUMANIntAct17353931 details
THIO_HUMANF107A_HUMANIntAct17353931 details
THIO_HUMANHLAB_HUMANIntAct17353931 details
THIO_HUMANEPB41_HUMANIntAct17353931 details
THIO_HUMAN1433Z_HUMANMINT15161933 details
THIO_HUMANPRDX2_HUMANBioGRID, DIP, MINT17557078 25402766 26344197 details
THIO_HUMANPRDX1_HUMANBioGRID, MINT10843682 17557078 26344197 details
THIO_HUMANPTN1_HUMANMINT24976139 details
THIO_HUMANNFKB1_HUMANBioGRID, HPRD, MINT25609649 7788295 details
THIO_HUMANSTAT3_HUMANDIP25402766 details
THIO_HUMANPTN6_HUMANBioGRID19561639 details
THIO_HUMANAKTIP_HUMANBioGRID27512140 details
THIO_HUMANFGF11_HUMANBioGRID28027390 details
THIO_HUMANSENP1_HUMANBioGRID18219322 details
THIO_HUMANALR_HUMANHPRD15894171 details