Entity Details

Primary name PNMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP11086
EntryNamePNMT_HUMAN
FullNamePhenylethanolamine N-methyltransferase
TaxID9606
Evidenceevidence at protein level
Length282
SequenceStatuscomplete
DateCreated1989-07-01
DateModified2021-06-02

Ontological Relatives

GenesPNMT

GO terms

Show/Hide Table
GOName
GO:0004603 phenylethanolamine N-methyltransferase activity
GO:0005829 cytosol
GO:0008170 N-methyltransferase activity
GO:0032259 methylation
GO:0042418 epinephrine biosynthetic process
GO:0042423 catecholamine biosynthetic process

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000940 Methyltransferase, NNMT/PNMT/TEMTFamilyFamily
IPR025820 Methyltransferase NNMT/PNMT/TEMT, conserved siteSiteConserved site
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily

Diseases

Show/Hide Table

Drugs

Show/Hide Table
DrugNameSourceType
DB01752 S-adenosyl-L-homocysteineDrugbanksmall molecule
DB03468 1,2,3,4-Tetrahydro-Isoquinoline-7-Sulfonic Acid AmideDrugbanksmall molecule
DB03824 7-Iodo-1,2,3,4-Tetrahydro-IsoquinolineDrugbanksmall molecule
DB04273 8,9-Dichloro-2,3,4,5-Tetrahydro-1h-Benzo[C]AzepineDrugbanksmall molecule
DB07597 CIS-(1R,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OLDrugbanksmall molecule
DB07739 (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINEDrugbanksmall molecule
DB07747 (3R)-N-(4-CHLOROPHENYL)-3-(HYDROXYMETHYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDEDrugbanksmall molecule
DB07798 (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDEDrugbanksmall molecule
DB07906 [(3R)-7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLIN-3-YL]METHANOLDrugbanksmall molecule
DB08128 (1S,4R,9S)-5-(trifluoromethyl)-1,2,3,4-tetrahydro-1,4-methanonaphthalen-9-amineDrugbanksmall molecule
DB08129 (1R)-2-amino-1-[3-(trifluoromethyl)phenyl]ethanolDrugbanksmall molecule
DB08550 7,8-Dichloro-1,2,3,4-tetrahydroisoquinolineDrugbanksmall molecule
DB08631 N-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDEDrugbanksmall molecule
DB08654 TRANS-(1S,2S)-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALEN-1-OLDrugbanksmall molecule
DB09571 LevmetamfetamineSwissprotsmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
PNMT_HUMANTERF1_HUMANbhf-ucl, BioGRID21044950 details
PNMT_HUMANTE2IP_HUMANbhf-ucl, BioGRID21044950 details
PNMT_HUMANKLHL8_HUMANBioGRID, IntAct32296183 details
PNMT_HUMANLNX1_HUMANBioGRID, IntAct32296183 details