Entity Details

Primary name IMDH2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12268
EntryNameIMDH2_HUMAN
FullNameInosine-5'-monophosphate dehydrogenase 2
TaxID9606
Evidenceevidence at protein level
Length514
SequenceStatuscomplete
DateCreated1989-10-01
DateModified2021-06-02

Ontological Relatives

GenesIMPDH2

GO terms

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GOName
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003938 IMP dehydrogenase activity
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
GO:0007623 circadian rhythm
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0016020 membrane
GO:0034774 secretory granule lumen
GO:0043312 neutrophil degranulation
GO:0046872 metal ion binding
GO:0070062 extracellular exosome
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000644 CBS domainDomainDomain
IPR001093 IMP dehydrogenase/GMP reductaseDomainDomain
IPR005990 Inosine-5'-monophosphate dehydrogenaseFamilyFamily
IPR013785 Aldolase-type TIM barrelFamilyHomologous superfamily
IPR015875 IMP dehydrogenase / GMP reductase, conserved siteSiteConserved site

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB00688 Mycophenolate mofetilDrugbanksmall molecule
DB00811 RibavirinDrugbanksmall molecule
DB00993 AzathioprineDrugbanksmall molecule
DB01024 Mycophenolic acidDrugbanksmall molecule
DB01033 MercaptopurineDrugbanksmall molecule
DB03070 Selenazole-4-carboxyamide-adenine dinucleotideDrugbanksmall molecule
DB03948 6-Chloropurine Riboside, 5'-MonophosphateDrugbanksmall molecule
DB04566 Inosinic AcidDrugbanksmall molecule
DB06103 VX-148Drugbanksmall molecule

Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
IMDH2_HUMANPIAS4_HUMANBioGRID, HPRD, IntAct15383276 details
IMDH2_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16713569 details
IMDH2_HUMANMTNB_HUMANBioGRID, IntAct25416956 details
IMDH2_HUMANCPLN2_HUMANBioGRID, IntAct25416956 32296183 details
IMDH2_HUMANIMDH2_HUMANBioGRID, IntAct25416956 details
IMDH2_HUMANTRAF2_HUMANBioGRID, IntAct32296183 details
IMDH2_HUMANPO6F2_HUMANBioGRID, IntAct32296183 details
IMDH2_HUMANIMDH1_HUMANBioGRID, IntAct22863883 22939629 26186194 26344197 28514442 32296183 34079125 details
IMDH2_HUMANSTAT3_HUMANBioGRID, IntAct32296183 details
IMDH2_HUMANAGR2_HUMANBioGRID, IntAct32296183 details
IMDH2_HUMANIL1FA_HUMANBioGRID, IntAct32296183 details
IMDH2_HUMANANKR9_HUMANBioGRID, IntAct26186194 28514442 30293565 31337707 details
IMDH2_HUMANAKT1_HUMANBioGRID, HPRD10930578 details
IMDH2_HUMANCLK1_HUMANBioGRID26167880 details
IMDH2_HUMANSUMO2_HUMANBioGRID32786267 details
IMDH2_HUMANOGT1_HUMANBioGRID32994395 details
IMDH2_HUMANTR10D_HUMANIntAct17353931 details
IMDH2_HUMANARF6_HUMANIntAct17353931 details
IMDH2_HUMANTNIK_HUMANIntAct17353931 details
IMDH2_HUMANTRM7_HUMANIntAct17353931 details
IMDH2_HUMANIF6_HUMANIntAct17353931 details
IMDH2_HUMANHLAC_HUMANIntAct17353931 details
IMDH2_HUMANDISC1_HUMANIntAct31413325 details
IMDH2_HUMANFXR1_HUMANMINT21653829 details
IMDH2_HUMANFXR2_HUMANMINT21653829 details
IMDH2_HUMANHDAC5_HUMANBioGRID21081666 details
IMDH2_HUMANSIR6_HUMANBioGRID24169447 details
IMDH2_HUMANU2AF2_HUMANBioGRID26641092 details
IMDH2_HUMANSUMO4_HUMANHPRD16236267 details