Entity Details

Primary name XRCC6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP12956
EntryNameXRCC6_HUMAN
FullNameX-ray repair cross-complementing protein 6
TaxID9606
Evidenceevidence at protein level
Length609
SequenceStatuscomplete
DateCreated1990-01-01
DateModified2021-06-02

Ontological Relatives

GenesXRCC6

GO terms

Show/Hide Table
GOName
GO:0000723 telomere maintenance
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0000976 transcription cis-regulatory region binding
GO:0002218 activation of innate immune response
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0006266 DNA ligation
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006310 DNA recombination
GO:0007420 brain development
GO:0008022 protein C-terminus binding
GO:0008094 ATPase, acting on DNA
GO:0016020 membrane
GO:0030332 cyclin binding
GO:0032481 positive regulation of type I interferon production
GO:0032991 protein-containing complex
GO:0032993 protein-DNA complex
GO:0034774 secretory granule lumen
GO:0042162 telomeric DNA binding
GO:0043312 neutrophil degranulation
GO:0043564 Ku70:Ku80 complex
GO:0044877 protein-containing complex binding
GO:0045087 innate immune response
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048660 regulation of smooth muscle cell proliferation
GO:0051575 5'-deoxyribose-5-phosphate lyase activity
GO:0070419 nonhomologous end joining complex
GO:0071475 cellular hyperosmotic salinity response
GO:0071480 cellular response to gamma radiation
GO:0071481 cellular response to X-ray
GO:0075713 establishment of integrated proviral latency
GO:0097680 double-strand break repair via classical nonhomologous end joining
GO:1904813 ficolin-1-rich granule lumen

Subcellular Location

Show/Hide Table
Subcellular Location
Chromosome
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR003034 SAP domainDomainDomain
IPR005160 Ku70/Ku80 C-terminal armDomainDomain
IPR005161 Ku70/Ku80, N-terminal alpha/betaDomainDomain
IPR006164 Ku70/Ku80 beta-barrel domainDomainDomain
IPR006165 Ku70FamilyFamily
IPR016194 SPOC-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR027388 Ku70, bridge and pillars domain superfamilyFamilyHomologous superfamily
IPR036361 SAP domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

224 interactions

InteractorPartnerSourcesPublicationsLink
XRCC6_HUMANWRN_HUMANBioGRID, HPRD, IntAct, MINT10783163 10880505 11328876 12177300 14734561 26496610 28514442 30585729 details
XRCC6_HUMANXRCC5_HUMANBioGRID, DIP, HPRD, IntAct, MINT, Molecular Connections10207052 10219089 10446239 10750018 10757784 10783163 10984620 11196700 11493912 12145306 12519782 15023334 15367688 15520013 15910003 17159921 17283121 17308091 18809223 19118032 19177010 19906305 21070772 21172662 21454661 21679440 22451927 22863883 22939629 24981860 25574025 26344197 26446488 26496610 26774286 28035050 28514442 30021884 30585729 32296183 33005030 7699019 8702520 9488450 details
XRCC6_HUMANPARP1_HUMANBioGRID, HPRD, IntAct10400681 14734561 16490787 16794079 17283121 24140708 28514442 30585729 34079125 details
XRCC6_HUMANHD_HUMANBioGRID, HPRD, IntAct15383276 32814053 details
XRCC6_HUMANCLH1_HUMANBioGRID, HPRD, IntAct15383276 details
XRCC6_HUMANTADA3_HUMANBioGRID, IntAct15383276 details
XRCC6_HUMANTCPG_HUMANBioGRID, HPRD, IntAct15383276 details
XRCC6_HUMANZ512B_HUMANBioGRID, MINT15231748 details
XRCC6_HUMANSKIL_HUMANBioGRID, HPRD, MINT15231748 details
XRCC6_HUMANSMAD3_HUMANBioGRID, HPRD, MINT15231748 details
XRCC6_HUMANSMAD7_HUMANBioGRID, HPRD, MINT15231748 details
XRCC6_HUMANVATE1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANPAEP_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANPA1B3_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANRLA1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANSPB9_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANABCD4_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANPLRKT_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANGSE1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANNH2L1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANNIT1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANPECA1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANRRAS2_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANSNTA1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANACD_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANCDCA5_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANARAP1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANFMNL1_HUMANBioGRID, HPRD, IntAct16169070 23182705 details
XRCC6_HUMANHACL2_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANNOTC1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANPGAM1_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANRBBP4_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANTBCD_HUMANBioGRID, HPRD, IntAct16169070 details
XRCC6_HUMANJUPI2_HUMANBioGRID, HPRD, IntAct16169070 30585729 details
XRCC6_HUMANNCPR_HUMANHPRD, IntAct16169070 details
XRCC6_HUMANWBP4_HUMANBioGRID, MINT16055720 details
XRCC6_HUMANTE2IP_HUMANbhf-ucl, BioGRID, IntAct15100233 15383534 21044950 26496610 34079125 details
XRCC6_HUMANHXB7_HUMANBioGRID, IntAct17308091 details
XRCC6_HUMANPRKDC_HUMANBioGRID, HPRD, I2D, IntAct10064605 10446239 10750018 11279128 15520013 17308091 19303849 20711232 21575865 21969602 22939629 26175416 26446488 26496610 28345663 30585729 33005030 8422676 9312071 details
XRCC6_HUMANCEBPA_HUMANBioGRID, IntAct16490787 details
XRCC6_HUMANHMGA1_HUMANBioGRID, IntAct18850631 details
XRCC6_HUMANCOIL_HUMANBioGRID, MINT21070772 30585729 details
XRCC6_HUMANCSK21_HUMANBioGRID, I2D20711232 details
XRCC6_HUMANADCY7_HUMANBioGRID, IntAct21988832 details
XRCC6_HUMANCOPB_HUMANBioGRID, IntAct21988832 details
XRCC6_HUMANMP2K5_HUMANBioGRID, IntAct21988832 details
XRCC6_HUMANCAN11_HUMANBioGRID, IntAct21988832 details
XRCC6_HUMANCTBP2_HUMANBioGRID, IntAct21988832 details
XRCC6_HUMANEPS8_HUMANBioGRID, IntAct21988832 details
XRCC6_HUMANEP300_HUMANBioGRID, IntAct15023334 21988832 details
XRCC6_HUMANETS1_HUMANBioGRID, IntAct21575865 29912634 details
XRCC6_HUMANANXA1_HUMANBioGRID, MINT21900206 30585729 details
XRCC6_HUMANBTG1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANCKLF6_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANEFNA1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANHERP1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANM4K2_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANCENPU_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANPDK1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANPDPK1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANPNRC2_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANGATA_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANRASA1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANRGS2_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANRS10_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANC560_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANSEP15_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANSPRC_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANTKN1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANEID1_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANK0408_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANPFD3_HUMANBioGRID, MINT21900206 details
XRCC6_HUMANSIR1_HUMANUniProt15205477 17334224 details
XRCC6_HUMANDYSF_HUMANBioGRID, IntAct23414517 details
XRCC6_HUMANPPID_HUMANBioGRID, UniProt21146485 details
XRCC6_HUMANAP2C_HUMANIntAct24835590 details
XRCC6_HUMANXRCC4_HUMANBioGRID, DIP, IntAct15520013 17124166 26496610 26774286 details
XRCC6_HUMANTERF2_HUMANbhf-ucl, BioGRID, HPRD, IntAct10984620 11112778 21044950 26496610 details
XRCC6_HUMANNR1H4_HUMANBioGRID, UniProt19833092 details
XRCC6_HUMANDUX4_HUMANBioGRID, IntAct26816005 details
XRCC6_HUMANH2AX_HUMANBioGRID, IntAct15613478 18406329 20224553 23145133 28514442 details
XRCC6_HUMANDNLI3_HUMANBioGRID, IntAct12897160 28514442 30585729 details
XRCC6_HUMANTCTP_HUMANDIP, MINT22451927 27607350 details
XRCC6_HUMANWFS1_HUMANIntAct32814053 details
XRCC6_HUMANRNF11_HUMANIntAct32814053 details
XRCC6_HUMANPRGR_HUMANBioGRID, HPRD, IntAct10750018 unassigned2875 details
XRCC6_HUMANVAV_HUMANBioGRID, HPRD8524317 details
XRCC6_HUMANNCF4_HUMANBioGRID, HPRD9914162 details
XRCC6_HUMANMRE11_HUMANBioGRID, HPRD10508516 26344197 30585729 details
XRCC6_HUMANCBX5_HUMANBioGRID, HPRD11112778 details
XRCC6_HUMANCCNA1_HUMANBioGRID, HPRD15159402 details
XRCC6_HUMANCDK2_HUMANBioGRID15159402 25852190 details
XRCC6_HUMANNCOA6_HUMANBioGRID, HPRD10823961 12519782 30585729 details
XRCC6_HUMANKAT2A_HUMANBioGRID, HPRD9488450 details
XRCC6_HUMANCBP_HUMANBioGRID15023334 9488450 details
XRCC6_HUMANG3ST4_HUMANBioGRID, HPRD16169070 details
XRCC6_HUMANATP23_HUMANBioGRID, HPRD10219089 details
XRCC6_HUMANCLUS_HUMANBioGRID, HPRD10219089 12551933 19118032 19177010 21042904 details
XRCC6_HUMANTERT_HUMANBioGRID, HPRD12377759 details
XRCC6_HUMANHXC4_HUMANBioGRID, HPRD11279128 12672812 details
XRCC6_HUMANHXD4_HUMANBioGRID11279128 details
XRCC6_HUMANDLX2_HUMANBioGRID11279128 details
XRCC6_HUMANPO2F2_HUMANBioGRID, HPRD11279128 details
XRCC6_HUMANPO2F1_HUMANBioGRID, HPRD11279128 12672812 17213819 27465491 details
XRCC6_HUMANPTTG1_HUMANBioGRID, HPRD11238996 details
XRCC6_HUMANTNR5_HUMANBioGRID, HPRD10514012 details
XRCC6_HUMANPCNA_HUMANBioGRID, HPRD11239001 12171929 24695737 details
XRCC6_HUMANHSF1_HUMANBioGRID, HPRD11162511 details
XRCC6_HUMANSIR3_HUMANBioGRID18710944 details
XRCC6_HUMANPDX1_HUMANBioGRID16166097 details
XRCC6_HUMANKAT2B_HUMANBioGRID15023334 details
XRCC6_HUMANCAF1A_HUMANBioGRID21209461 details
XRCC6_HUMANBAZ1A_HUMANBioGRID21172662 details
XRCC6_HUMANMDM2_HUMANBioGRID19247369 24147044 details
XRCC6_HUMANRN146_HUMANBioGRID21825151 details
XRCC6_HUMANMSH6_HUMANBioGRID21075794 22863883 30585729 details
XRCC6_HUMANXRCC6_HUMANBioGRID10750018 30585729 details
XRCC6_HUMANNUCL_HUMANBioGRID23145133 30585729 details
XRCC6_HUMANGRAA_HUMANBioGRID16440001 details
XRCC6_HUMANGRAB_HUMANBioGRID8760815 details
XRCC6_HUMANHMGA2_HUMANBioGRID18850631 details
XRCC6_HUMANPR40A_HUMANBioGRID16055720 details
XRCC6_HUMANPIN1_HUMANBioGRID16055720 details
XRCC6_HUMANSET_HUMANBioGRID22863883 27626385 30585729 details
XRCC6_HUMANELF3_HUMANBioGRID15075319 details
XRCC6_HUMANEHF_HUMANBioGRID15075319 details
XRCC6_HUMANSUMO2_HUMANBioGRID19394292 details
XRCC6_HUMANAP2A_HUMANBioGRID19906305 details
XRCC6_HUMANRN126_HUMANBioGRID27895153 details
XRCC6_HUMANTOP1_HUMANBioGRID28415827 30585729 details
XRCC6_HUMANUBC_HUMANBioGRID26774286 details
XRCC6_HUMANZBT7A_HUMANBioGRID26446488 details
XRCC6_HUMANUBP14_HUMANBioGRID30425250 30585729 31740976 details
XRCC6_HUMANPTEN_HUMANBioGRID31685992 details
XRCC6_HUMANASXL1_HUMANBioGRID32683582 details
XRCC6_HUMANOGT1_HUMANBioGRID32994395 details
XRCC6_HUMANNSMA2_HUMANIntAct16169070 details
XRCC6_HUMANNDRG1_HUMANBioGRID, IntAct17220478 details
XRCC6_HUMANTF7L2_HUMANBioGRID, IntAct17283121 27684187 30833792 details
XRCC6_HUMANAPLF_HUMANBioGRID, IntAct, MINT17396150 23178593 26186194 27067600 28514442 details
XRCC6_HUMANP53_HUMANBioGRID, HPRD, UniProt11751391 15782130 32807901 details
XRCC6_HUMANBARD1_HUMANBioGRID, HPRD, UniProt15782130 22990118 details
XRCC6_HUMANKAP0_HUMANIntAct20195357 details
XRCC6_HUMANPIAS4_HUMANMINT19779455 details
XRCC6_HUMANBAX_HUMANBioGRID, UniProt15205477 19118032 19177010 19247369 21042904 25299772 details
XRCC6_HUMANHMBX1_HUMANMINT23685356 details
XRCC6_HUMANABL1_HUMANBioGRID, HPRD, IntAct25852190 9798959 details
XRCC6_HUMANDNLI4_HUMANBioGRID, IntAct10757784 15520013 22990118 26496610 details
XRCC6_HUMANPPM1G_HUMANBioGRID, IntAct28330616 30585729 details
XRCC6_HUMANCHD1L_HUMANBioGRID, DIP, IntAct19661379 19666485 23926104 28514442 details
XRCC6_HUMANH31_HUMANBioGRID, DIP, IntAct, MINT20080577 20504901 21187428 25281560 26527279 29568061 34079125 details
XRCC6_HUMANDTBP1_HUMANUniProt19142223 details
XRCC6_HUMANDEAF1_HUMANUniProt22442688 details
XRCC6_HUMANH2AZ_HUMANBioGRID, DIP24463511 29985131 details
XRCC6_HUMANWAPL_HUMANBioGRID, IntAct30021884 30585729 details
XRCC6_HUMANANDR_HUMANBioGRID, HPRD15640154 details
XRCC6_HUMANCHK1_HUMANBioGRID, HPRD12756247 details
XRCC6_HUMANRFA2_HUMANBioGRID10064605 24332808 24981860 26344197 details
XRCC6_HUMANTDT_HUMANBioGRID, HPRD10570175 details
XRCC6_HUMANTAL1_HUMANBioGRID16407974 details
XRCC6_HUMANBIN1_HUMANBioGRID17671430 details
XRCC6_HUMANDHX9_HUMANBioGRID15723802 30585729 details
XRCC6_HUMANFCSD1_HUMANBioGRID19041431 details
XRCC6_HUMANSIR6_HUMANBioGRID20157594 details
XRCC6_HUMANESR1_HUMANBioGRID16794079 details
XRCC6_HUMANMGMT_HUMANBioGRID16226712 details
XRCC6_HUMANSRRM2_HUMANBioGRID16159877 details
XRCC6_HUMANMSX2_HUMANBioGRID, HPRD12145306 12145307 details
XRCC6_HUMANRUNX2_HUMANBioGRID, HPRD12145306 12145308 details
XRCC6_HUMANNAA15_HUMANBioGRID, HPRD12145306 12145309 details
XRCC6_HUMANPHF1_HUMANBioGRID18385154 details
XRCC6_HUMANATX3_HUMANBioGRID17885668 30455355 details
XRCC6_HUMANILF2_HUMANBioGRID17389650 details
XRCC6_HUMANTHA_HUMANBioGRID17242407 details
XRCC6_HUMANTHB_HUMANBioGRID17242407 details
XRCC6_HUMANBIRC5_HUMANBioGRID20394854 details
XRCC6_HUMANH33_HUMANBioGRID20504901 details
XRCC6_HUMANHDAC5_HUMANBioGRID21081666 details
XRCC6_HUMANUBE3A_HUMANBioGRID16051665 details
XRCC6_HUMANRBM39_HUMANBioGRID16051665 28302793 details
XRCC6_HUMANDDB2_HUMANBioGRID20368362 details
XRCC6_HUMANTYY1_HUMANBioGRID15367688 30585729 details
XRCC6_HUMANSMRCD_HUMANBioGRID21549307 details
XRCC6_HUMANORC3_HUMANBioGRID15910003 details
XRCC6_HUMANORC2_HUMANBioGRID15910003 30585729 31160578 details
XRCC6_HUMANORC6_HUMANBioGRID15910003 details
XRCC6_HUMANORC4_HUMANBioGRID15910003 details
XRCC6_HUMANILF3_HUMANBioGRID21969602 30585729 31536960 details
XRCC6_HUMANMSH2_HUMANBioGRID21075794 22863883 details
XRCC6_HUMANSIR7_HUMANBioGRID22586326 28655758 details
XRCC6_HUMANCFLAR_HUMANBioGRID22322857 details
XRCC6_HUMANHDAC6_HUMANBioGRID21847364 25299772 details
XRCC6_HUMANKCND3_HUMANBioGRID17725712 details
XRCC6_HUMANPNKP_HUMANBioGRID15385968 details
XRCC6_HUMANITA4_HUMANBioGRID22623428 details
XRCC6_HUMANPPARG_HUMANBioGRID18809223 details
XRCC6_HUMANPHRF1_HUMANBioGRID25855964 details
XRCC6_HUMANBANP_HUMANBioGRID25299772 details
XRCC6_HUMANMACD1_HUMANBioGRID25735744 details
XRCC6_HUMANU2AF2_HUMANBioGRID26641092 30585729 details
XRCC6_HUMANFOXL2_HUMANBioGRID22544055 details
XRCC6_HUMANAHSA1_HUMANBioGRID22504172 details
XRCC6_HUMANSPTA1_HUMANBioGRID16889989 details
XRCC6_HUMANUBE2S_HUMANBioGRID27593939 details
XRCC6_HUMANHIF1A_HUMANBioGRID15272235 details
XRCC6_HUMANUBP50_HUMANBioGRID29101126 details
XRCC6_HUMANNOP53_HUMANBioGRID27829214 details
XRCC6_HUMANHEXI1_HUMANBioGRID29845934 details
XRCC6_HUMANRECQ4_HUMANBioGRID29229926 details
XRCC6_HUMANCDC37_HUMANBioGRID16611982 details
XRCC6_HUMANAPEX1_HUMANBioGRID, HPRD30585729 34079125 8621488 details
XRCC6_HUMANMARCS_HUMANBioGRID30942445 details
XRCC6_HUMANSOX2_HUMANBioGRID21280222 details
XRCC6_HUMANCMTR1_HUMANBioGRID30320910 details
XRCC6_HUMANLRC31_HUMANBioGRID33005030 details
XRCC6_HUMANDTX2_HUMANBioGRID32937373 details
XRCC6_HUMANEIF3H_HUMANBioGRID32269044 details
XRCC6_HUMANNEMO_HUMANBioGRID31932854 details
XRCC6_HUMANCDN1A_HUMANHPRD9798959 details
XRCC6_HUMANITF2_HUMANHPRD17283121 details
XRCC6_HUMANSGO1_HUMANHPRD16541024 details
XRCC6_HUMANEGFR_HUMANHPRD9430697 details
XRCC6_HUMANMK08_HUMANHPRD11749722 details