Entity Details

Primary name IL1R1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14778
EntryNameIL1R1_HUMAN
FullNameInterleukin-1 receptor type 1
TaxID9606
Evidenceevidence at protein level
Length569
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesIL1R1

GO terms

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GOName
GO:0002020 protease binding
GO:0004888 transmembrane signaling receptor activity
GO:0004908 interleukin-1 receptor activity
GO:0004909 interleukin-1, type I, activating receptor activity
GO:0005161 platelet-derived growth factor receptor binding
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0019221 cytokine-mediated signaling pathway
GO:0019966 interleukin-1 binding
GO:0032729 positive regulation of interferon-gamma production
GO:0050135 NAD(P)+ nucleosidase activity
GO:0050727 regulation of inflammatory response
GO:0061809 NAD+ nucleotidase, cyclic ADP-ribose generating
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:2000391 positive regulation of neutrophil extravasation
GO:2000556 positive regulation of T-helper 1 cell cytokine production
GO:2000661 positive regulation of interleukin-1-mediated signaling pathway

Subcellular Location

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Subcellular Location
Cell membrane
Membrane
Secreted

Domains

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DomainNameCategoryType
IPR000157 Toll/interleukin-1 receptor homology (TIR) domainDomainDomain
IPR003599 Immunoglobulin subtypeDomainDomain
IPR004074 Interleukin-1 receptor type I/IIFamilyFamily
IPR004076 Interleukin-1 receptor type 1FamilyFamily
IPR007110 Immunoglobulin-like domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR015621 Interleukin-1 receptor familyFamilyFamily
IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamilyFamilyHomologous superfamily
IPR036179 Immunoglobulin-like domain superfamilyFamilyHomologous superfamily
IPR041416 IL-1Ra-like, immunoglobulin domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00026 AnakinraDrugbankbiotech
DB05207 SD118Drugbanksmall molecule
DB05303 OMS-103HPDrugbanksmall molecule
DB10770 Foreskin fibroblast (neonatal)Drugbankbiotech