Entity Details

Primary name MMP9_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP14780
EntryNameMMP9_HUMAN
FullNameMatrix metalloproteinase-9
TaxID9606
Evidenceevidence at protein level
Length707
SequenceStatuscomplete
DateCreated1990-04-01
DateModified2021-06-02

Ontological Relatives

GenesMMP9

GO terms

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GOName
GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001934 positive regulation of protein phosphorylation
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005518 collagen binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0006508 proteolysis
GO:0007566 embryo implantation
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0019221 cytokine-mediated signaling pathway
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030225 macrophage differentiation
GO:0030335 positive regulation of cell migration
GO:0030574 collagen catabolic process
GO:0034614 cellular response to reactive oxygen species
GO:0035987 endodermal cell differentiation
GO:0042802 identical protein binding
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0043388 positive regulation of DNA binding
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0050900 leukocyte migration
GO:0051549 positive regulation of keratinocyte migration
GO:0062023 collagen-containing extracellular matrix
GO:0070062 extracellular exosome
GO:0071276 cellular response to cadmium ion
GO:0071492 cellular response to UV-A
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0150077 regulation of neuroinflammatory response
GO:1900122 positive regulation of receptor binding
GO:1904645 response to amyloid-beta
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation
GO:1904724 tertiary granule lumen
GO:1904813 ficolin-1-rich granule lumen
GO:2000697 negative regulation of epithelial cell differentiation involved in kidney development
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
GO:2001258 negative regulation of cation channel activity
GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000562 Fibronectin type II domainDomainDomain
IPR000585 Hemopexin-like domainDomainDomain
IPR001818 Peptidase M10, metallopeptidaseDomainDomain
IPR002477 Peptidoglycan binding-likeDomainDomain
IPR006026 Peptidase, metallopeptidaseDomainDomain
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018486 Hemopexin, conserved siteSiteConserved site
IPR018487 Hemopexin-like repeatsRepeatRepeat
IPR021158 Peptidase M10A, cysteine switch, zinc binding siteSiteBinding site
IPR021190 Peptidase M10AFamilyFamily
IPR024079 Metallopeptidase, catalytic domain superfamilyFamilyHomologous superfamily
IPR028688 Matrix metalloproteinase-9FamilyFamily
IPR033739 Peptidase M10A, catalytic domainDomainDomain
IPR036365 PGBD-like superfamilyFamilyHomologous superfamily
IPR036366 PGBD superfamilyFamilyHomologous superfamily
IPR036375 Hemopexin-like domain superfamilyFamilyHomologous superfamily
IPR036943 Fibronectin type II domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00786 MarimastatDrugbanksmall molecule
DB01017 MinocyclineDrugbanksmall molecule
DB01197 CaptoprilDrugbanksmall molecule
DB01296 GlucosamineDrugbanksmall molecule
DB01593 ZincDrugbanksmall molecule
DB01949 2-Amino-N,3,3-TrimethylbutanamideDrugbanksmall molecule
DB03683 2-{[Formyl(Hydroxy)Amino]Methyl}-4-Methylpentanoic AcidDrugbanksmall molecule
DB05387 AE-941Drugbanksmall molecule
DB05495 PG-530742Drugbanksmall molecule
DB06423 EndostatinDrugbankbiotech
DB07117 5-(4-PHENOXYPHENYL)-5-(4-PYRIMIDIN-2-YLPIPERAZIN-1-YL)PYRIMIDINE-2,4,6(2H,3H)-TRIONEDrugbanksmall molecule
DB07246 (2R)-2-AMINO-3,3,3-TRIFLUORO-N-HYDROXY-2-{[(4-PHENOXYPHENYL)SULFONYL]METHYL}PROPANAMIDEDrugbanksmall molecule
DB07285 (3R)-4,4-DIFLUORO-3-[(4-METHOXYPHENYL)SULFONYL]BUTANOIC ACIDDrugbanksmall molecule
DB14487 Zinc acetateDrugbanksmall molecule
DB14533 Zinc chlorideDrugbanksmall molecule
DB14548 Zinc sulfate, unspecified formDrugbanksmall molecule

Interactions

42 interactions

InteractorPartnerSourcesPublicationsLink
MMP9_HUMANELN_HUMANMINT20345904 details
MMP9_HUMANSCUB3_HUMANI2D21441952 details
MMP9_HUMANMEP1A_HUMANMINT23123160 details
MMP9_HUMANMEP1B_HUMANMINT23123160 details
MMP9_HUMANTGFB1_HUMANBioGRID, IntAct10652271 25241761 details
MMP9_HUMANMMP9_HUMANDIP, HPRD, MINT12051944 17937912 18077379 23601700 details
MMP9_HUMANCSPG2_HUMANMINT23601700 details
MMP9_HUMANSRGN_HUMANMINT23601700 details
MMP9_HUMANTIMP1_HUMANBioGRID, IntAct24330623 28514442 details
MMP9_HUMANCXCL5_HUMANBioGRID, HPRD10095777 12950257 details
MMP9_HUMANCXCL6_HUMANBioGRID12950257 details
MMP9_HUMANTSP1_HUMANBioGRID, HPRD10900205 11606713 details
MMP9_HUMANTSP2_HUMANBioGRID, HPRD10900205 details
MMP9_HUMANBGH3_HUMANBioGRID23019342 details
MMP9_HUMANFINC_HUMANBioGRID, HPRD, IntAct11134254 28514442 details
MMP9_HUMANCO4A2_HUMANBioGRID, HPRD, IntAct28514442 9878537 details
MMP9_HUMANCO4A1_HUMANBioGRID, HPRD, IntAct28514442 9878537 details
MMP9_HUMANNGAL_HUMANDIP, HPRD10339412 1281792 18077379 details
MMP9_HUMANCLUS_HUMANBioGRID26716898 details
MMP9_HUMANCATB_HUMANBioGRID26208400 details
MMP9_HUMANHPLN1_HUMANHPRD7694569 details
MMP9_HUMANCO4A3_HUMANHPRD9878537 details
MMP9_HUMANCO4A4_HUMANHPRD9878537 details
MMP9_HUMANCO1A1_HUMANHPRD9878537 details
MMP9_HUMANCO1A2_HUMANHPRD9878537 details
MMP9_HUMANIL8_HUMANHPRD11023497 details
MMP9_HUMANGROA_HUMANHPRD11023497 details
MMP9_HUMANPLMN_HUMANHPRD9360944 details
MMP9_HUMANMMP7_HUMANHPRD7896811 details
MMP9_HUMANTIMP3_HUMANHPRD11827795 details
MMP9_HUMANCO4A5_HUMANHPRD9878537 details
MMP9_HUMANCO4A6_HUMANHPRD9878537 details
MMP9_HUMANBTC_HUMANHPRD10706134 details
MMP9_HUMANKISS1_HUMANHPRD12879005 details
MMP9_HUMANRECK_HUMANHPRD9789069 details
MMP9_HUMANMMP26_HUMANHPRD12586837 details
MMP9_HUMANTFPI1_HUMANHPRD10859319 details
MMP9_HUMANTRY2_HUMANHPRD9261109 9578462 details
MMP9_HUMANMMP10_HUMANHPRD9578462 details
MMP9_HUMANEPHB2_HUMANHPRD18713744 details
MMP9_HUMANAREG_HUMANHPRD10389762 details
MMP9_HUMANCD44_HUMANHPRD10652271 17912438 details