Entity Details

Primary name PLCG2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP16885
EntryNamePLCG2_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
TaxID9606
Evidenceevidence at protein level
Length1265
SequenceStatuscomplete
DateCreated1990-08-01
DateModified2021-06-02

Ontological Relatives

GenesPLCG2

GO terms

Show/Hide Table
GOName
GO:0001784 phosphotyrosine residue binding
GO:0002092 positive regulation of receptor internalization
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002316 follicular B cell differentiation
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006661 phosphatidylinositol biosynthetic process
GO:0009395 phospholipid catabolic process
GO:0010628 positive regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0016055 Wnt signaling pathway
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030168 platelet activation
GO:0030183 B cell differentiation
GO:0032237 activation of store-operated calcium channel activity
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032959 inositol trisphosphate biosynthetic process
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043069 negative regulation of programmed cell death
GO:0043647 inositol phosphate metabolic process
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051091 positive regulation of DNA-binding transcription factor activity
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070062 extracellular exosome
GO:0071277 cellular response to calcium ion
GO:0097110 scaffold protein binding
GO:0140031 phosphorylation-dependent protein binding
GO:1902808 positive regulation of cell cycle G1/S phase transition

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gammaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2FamilyFamily
IPR035023 PLC-gamma, C-terminal SH2 domainDomainDomain
IPR035024 PLC-gamma, N-terminal SH2 domainDomainDomain
IPR035723 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

73 interactions

InteractorPartnerSourcesPublicationsLink
PLCG2_HUMANEPOR_HUMANHPRD, IntAct15644415 15953601 details
PLCG2_HUMANZ512B_HUMANBioGRID, MINT15231748 details
PLCG2_HUMANEGFR_HUMANBioGRID, IntAct, MINT16273093 22973453 24658140 25241761 25402006 31980649 details
PLCG2_HUMANERBB2_HUMANBioGRID, IntAct, MINT16273093 22973453 25241761 details
PLCG2_HUMANGRB2_HUMANIntAct17474147 details
PLCG2_HUMANP85A_HUMANBioGRID, IntAct17474147 25241761 details
PLCG2_HUMANMED28_HUMANMINT16964398 details
PLCG2_HUMANANDR_HUMANBioGRID, IntAct24728074 details
PLCG2_HUMANGAB1_HUMANBioGRID, HPRD, IntAct11507676 24728074 details
PLCG2_HUMANKIT_HUMANBioGRID, IntAct24728074 details
PLCG2_HUMANMET_HUMANBioGRID, IntAct24728074 details
PLCG2_HUMANEPYC_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANLHX8_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANELK1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANCH60_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANP53_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANPTTG1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANKCD17_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANBOP_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANZKSC7_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANASB9_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANTWST2_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANGABP2_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANSETD9_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANRBP1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANISL1_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANESTD_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANFSBP_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANPSMD3_HUMANBioGRID, IntAct25814554 details
PLCG2_HUMANCD244_HUMANUniProt24642916 details
PLCG2_HUMANSH21B_HUMANUniProt24642916 details
PLCG2_HUMANLAT_HUMANBioGRID, HPRD, UniProt10469124 24642916 27221712 details
PLCG2_HUMANLYN_HUMANBioGRID, HPRD10981967 12181444 15144186 7682059 8395016 details
PLCG2_HUMANFYN_HUMANBioGRID, HPRD12181444 15144186 7682059 8395016 details
PLCG2_HUMANBLK_HUMANBioGRID, HPRD8395016 details
PLCG2_HUMANIRS1_HUMANBioGRID22974441 details
PLCG2_HUMANRA54B_HUMANBioGRID25814554 details
PLCG2_HUMANPTN6_HUMANBioGRID27221712 details
PLCG2_HUMANCD19_HUMANBioGRID, HPRD10706702 15187135 details
PLCG2_HUMANERBB3_HUMANBioGRID22973453 details
PLCG2_HUMANERBB4_HUMANBioGRID22973453 details
PLCG2_HUMANVGFR1_HUMANHPRD9398617 details
PLCG2_HUMAN3BP2_HUMANHPRD, MINT11390470 details
PLCG2_HUMANBLNK_HUMANBioGRID, HPRD, MINT11274146 21822214 details
PLCG2_HUMANEPHA4_HUMANIntAct31413325 details
PLCG2_HUMANSHC1_HUMANBioGRID, HPRD10623845 12135708 details
PLCG2_HUMANGAB2_HUMANBioGRID, HPRD12135708 details
PLCG2_HUMANPTN11_HUMANBioGRID12135708 details
PLCG2_HUMANKPCD1_HUMANBioGRID, HPRD8885868 details
PLCG2_HUMANBTK_HUMANBioGRID, HPRD10981967 11507089 12093870 17290227 details
PLCG2_HUMANCBLB_HUMANBioGRID, HPRD12093870 details
PLCG2_HUMANNTAL_HUMANBioGRID, HPRD12514734 details
PLCG2_HUMANVAV_HUMANBioGRID10981967 details
PLCG2_HUMANKSYK_HUMANBioGRID, HPRD10933389 10981967 12470302 12771181 details
PLCG2_HUMANPLXB1_HUMANBioGRID19805522 details
PLCG2_HUMANKPCA_HUMANBioGRID16923831 details
PLCG2_HUMANPLD1_HUMANBioGRID16923831 details
PLCG2_HUMANBCAP_HUMANBioGRID27909057 details
PLCG2_HUMANTAU_HUMANBioGRID9592050 details
PLCG2_HUMANVGFR2_HUMANHPRD9398617 details
PLCG2_HUMANLCP2_HUMANHPRD10469124 details
PLCG2_HUMANKHDR1_HUMANHPRD10467411 details
PLCG2_HUMANPLCG2_HUMANHPRD9819383 details
PLCG2_HUMANNPM_HUMANHPRD9819383 details
PLCG2_HUMANJAK1_HUMANHPRD14978237 details
PLCG2_HUMANJAK2_HUMANHPRD14978237 details
PLCG2_HUMANITK_HUMANHPRD15184383 details
PLCG2_HUMANTEC_HUMANHPRD15184383 details
PLCG2_HUMANDAPP1_HUMANHPRD10770799 details
PLCG2_HUMANLIME1_HUMANHPRD16249387 details
PLCG2_HUMANFCERG_HUMANHPRD10469124 details
PLCG2_HUMANHCK_HUMANHPRD12181444 15144186 7682059 details
PLCG2_HUMANLCK_HUMANHPRD12181444 15144186 7682059 details