Entity Details

Primary name TFEB_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP19484
EntryNameTFEB_HUMAN
FullNameTranscription factor EB
TaxID9606
Evidenceevidence at protein level
Length476
SequenceStatuscomplete
DateCreated1991-02-01
DateModified2021-06-02

Ontological Relatives

GenesTFEB

GO terms

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GOName
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001892 embryonic placenta development
GO:0002250 adaptive immune response
GO:0003700 DNA-binding transcription factor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006914 autophagy
GO:0006959 humoral immune response
GO:0007040 lysosome organization
GO:0009267 cellular response to starvation
GO:0010468 regulation of gene expression
GO:0010508 positive regulation of autophagy
GO:0019899 enzyme binding
GO:0032418 lysosome localization
GO:0034198 cellular response to amino acid starvation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046983 protein dimerization activity
GO:1990837 sequence-specific double-stranded DNA binding

Subcellular Location

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Subcellular Location
Cytoplasm
Lysosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domainDomainDomain
IPR021802 MiT/TFE transcription factors, C-terminalDomainDomain
IPR024098 Transcription factor EBFamilyFamily
IPR031867 MiT/TFE transcription factors, N-terminalDomainDomain
IPR036638 Helix-loop-helix DNA-binding domain superfamilyFamilyHomologous superfamily

Diseases

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