Entity Details

Primary name PTN_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21246
EntryNamePTN_HUMAN
FullNamePleiotrophin
TaxID9606
Evidenceevidence at protein level
Length168
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesPTN

GO terms

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GOName
GO:0001889 liver development
GO:0002232 leukocyte chemotaxis involved in inflammatory response
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0004864 protein phosphatase inhibitor activity
GO:0005178 integrin binding
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007399 nervous system development
GO:0007406 negative regulation of neuroblast proliferation
GO:0007507 heart development
GO:0007612 learning
GO:0007613 memory
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008284 positive regulation of cell population proliferation
GO:0008360 regulation of cell shape
GO:0009986 cell surface
GO:0010594 regulation of endothelial cell migration
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010976 positive regulation of neuron projection development
GO:0010996 response to auditory stimulus
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0019901 protein kinase binding
GO:0021510 spinal cord development
GO:0021549 cerebellum development
GO:0021794 thalamus development
GO:0030282 bone mineralization
GO:0030324 lung development
GO:0030336 negative regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0031104 dendrite regeneration
GO:0031594 neuromuscular junction
GO:0031641 regulation of myelination
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0035373 chondroitin sulfate proteoglycan binding
GO:0035374 chondroitin sulfate binding
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038085 vascular endothelial growth factor binding
GO:0042246 tissue regeneration
GO:0042493 response to drug
GO:0043065 positive regulation of apoptotic process
GO:0043113 receptor clustering
GO:0043932 ossification involved in bone remodeling
GO:0044849 estrous cycle
GO:0045446 endothelial cell differentiation
GO:0045545 syndecan binding
GO:0045778 positive regulation of ossification
GO:0045837 negative regulation of membrane potential
GO:0046697 decidualization
GO:0048167 regulation of synaptic plasticity
GO:0048471 perinuclear region of cytoplasm
GO:0048477 oogenesis
GO:0048680 positive regulation of axon regeneration
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060221 retinal rod cell differentiation
GO:0060253 negative regulation of glial cell proliferation
GO:0060291 long-term synaptic potentiation
GO:0071305 cellular response to vitamin D
GO:0071456 cellular response to hypoxia
GO:0072201 negative regulation of mesenchymal cell proliferation
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0140059 dendrite arborization
GO:1900006 positive regulation of dendrite development
GO:1900272 negative regulation of long-term synaptic potentiation
GO:1903706 regulation of hemopoiesis
GO:1904373 response to kainic acid
GO:1904389 rod bipolar cell differentiation
GO:1904391 response to ciliary neurotrophic factor
GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering
GO:1904397 negative regulation of neuromuscular junction development
GO:1904399 heparan sulfate binding
GO:1990089 response to nerve growth factor
GO:2000036 regulation of stem cell population maintenance
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000738 positive regulation of stem cell differentiation

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR000762 Midkine heparin-binding growth factorFamilyFamily
IPR020089 Pleiotrophin/Midkine, N-terminal domainDomainDomain
IPR020090 Pleiotrophin/Midkine, C-terminal domainDomainDomain
IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamilyFamilyHomologous superfamily
IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved siteSiteConserved site
IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamilyFamilyHomologous superfamily
IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

108 interactions

InteractorPartnerSourcesPublicationsLink
PTN_HUMANBARD1_HUMANBioGRID, HPRD, IntAct15383276 details
PTN_HUMANCHD3_HUMANBioGRID, HPRD, IntAct15383276 16169070 details
PTN_HUMANIMB1_HUMANBioGRID, HPRD, IntAct15383276 details
PTN_HUMANGA45G_HUMANBioGRID, HPRD, IntAct15383276 details
PTN_HUMANFEZ1_HUMANBioGRID, HPRD, IntAct15383276 details
PTN_HUMANPTN_HUMANBioGRID, HPRD, IntAct10600521 15383276 details
PTN_HUMANPIAS4_HUMANBioGRID, HPRD, IntAct15383276 details
PTN_HUMANGASP2_HUMANBioGRID, IntAct15383276 details
PTN_HUMANBCCIP_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANUBQL4_HUMANBioGRID, HPRD, IntAct16169070 16713569 details
PTN_HUMANPSMD2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSGTA_HUMANBioGRID, HPRD, IntAct16169070 21988832 details
PTN_HUMANARI2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANGIPC2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANRACK1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPP2AA_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPSD11_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPTPRS_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANRLA1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSGSM2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANTOM20_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANTXND9_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANARL15_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANATPG_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCAPZB_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANWASC3_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCREL1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANDJB11_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
PTN_HUMANEIF3F_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANS2536_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANGPDA_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANGSTP1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANLAMA4_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANLC7L2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANMD2BP_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPDIA1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSAS10_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSAT1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSSRA_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANASPP2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANATRX_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANBTBD2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCAAP1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCACB4_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCAD10_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCK5P2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCOX6C_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANDUS12_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANEVA1A_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANFRIL_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANBL1S1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANGLYAT_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANT2FA_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANITSN2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANAF9_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANMYCBP_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANNP1L5_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCRCT1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPMF1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPSB10_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANRIT1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSNCAP_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANSTC2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANTKNK_HUMANBioGRID, IntAct16169070 details
PTN_HUMANFAKD4_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANABC3G_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANGLHA_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANGSDME_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANHBAP1_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANTAF1D_HUMANBioGRID, HPRD, IntAct, MINT16169070 21900206 details
PTN_HUMANMKKS_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANPLXB2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANST65G_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANWFDC2_HUMANBioGRID, HPRD, IntAct16169070 details
PTN_HUMANCYTA_HUMANHPRD, IntAct16169070 details
PTN_HUMANSPIN1_HUMANHPRD, IntAct16169070 details
PTN_HUMANCP2E1_HUMANBioGRID, IntAct21988832 details
PTN_HUMANBAG6_HUMANBioGRID, IntAct21988832 details
PTN_HUMANT22D1_HUMANBioGRID, IntAct21988832 details
PTN_HUMANUBQL1_HUMANBioGRID, IntAct21988832 details
PTN_HUMANB2CL1_HUMANBioGRID, MINT21900206 details
PTN_HUMANSMAP_HUMANBioGRID, MINT21900206 details
PTN_HUMANCG025_HUMANBioGRID, MINT21900206 details
PTN_HUMANGA45A_HUMANBioGRID, MINT21900206 details
PTN_HUMANGSK3B_HUMANBioGRID, MINT21900206 details
PTN_HUMANRM44_HUMANBioGRID, MINT21900206 details
PTN_HUMANCPSF5_HUMANBioGRID, MINT21900206 details
PTN_HUMANPFD1_HUMANBioGRID, MINT21900206 details
PTN_HUMANASPH_HUMANBioGRID, IntAct32296183 details
PTN_HUMANITAM_HUMANUniProt28939773 details
PTN_HUMANSERPH_HUMANIntAct32814053 details
PTN_HUMANKAPCA_HUMANIntAct32814053 details
PTN_HUMANKLK6_HUMANIntAct32814053 details
PTN_HUMANTGFR2_HUMANIntAct32814053 details
PTN_HUMANBMI1_HUMANBioGRID, HPRD16169070 details
PTN_HUMANRBM23_HUMANBioGRID, HPRD16169070 details
PTN_HUMANHGH1_HUMANBioGRID, HPRD16169070 details
PTN_HUMANALK_HUMANBioGRID, HPRD11278720 details
PTN_HUMANNEK6_HUMANBioGRID20873783 details
PTN_HUMANPTPRZ_HUMANBioGRID, HPRD10706604 16814777 25644401 details
PTN_HUMANCTNB1_HUMANBioGRID10706604 details
PTN_HUMANPTPRB_HUMANBioGRID25644401 details
PTN_HUMANITAV_HUMANBioGRID19141530 details
PTN_HUMANITB3_HUMANBioGRID19141530 details
PTN_HUMANACTB_HUMANHPRD9739080 details
PTN_HUMANSDC1_HUMANHPRD7592855 details
PTN_HUMANSDC3_HUMANHPRD8175719 details
PTN_HUMANNCAN_HUMANHPRD9507007 details