Entity Details

Primary name TNAP3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21580
EntryNameTNAP3_HUMAN
FullNameTumor necrosis factor alpha-induced protein 3
TaxID9606
Evidenceevidence at protein level
Length790
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesTNFAIP3

GO terms

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GOName
GO:0001922 B-1 B cell homeostasis
GO:0002020 protease binding
GO:0002237 response to molecule of bacterial origin
GO:0002634 regulation of germinal center formation
GO:0002677 negative regulation of chronic inflammatory response
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004843 thiol-dependent deubiquitinase
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005829 cytosol
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007010 cytoskeleton organization
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0016477 cell migration
GO:0016579 protein deubiquitination
GO:0019900 kinase binding
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032480 negative regulation of type I interferon production
GO:0032495 response to muramyl dipeptide
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032703 negative regulation of interleukin-2 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0034136 negative regulation of toll-like receptor 2 signaling pathway
GO:0034140 negative regulation of toll-like receptor 3 signaling pathway
GO:0034144 negative regulation of toll-like receptor 4 signaling pathway
GO:0034148 negative regulation of toll-like receptor 5 signaling pathway
GO:0035523 protein K29-linked deubiquitination
GO:0035871 protein K11-linked deubiquitination
GO:0042802 identical protein binding
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043130 ubiquitin binding
GO:0043621 protein self-association
GO:0045732 positive regulation of protein catabolic process
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045779 negative regulation of bone resorption
GO:0045824 negative regulation of innate immune response
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050691 regulation of defense response to virus by host
GO:0050728 negative regulation of inflammatory response
GO:0050869 negative regulation of B cell activation
GO:0061043 regulation of vascular wound healing
GO:0061578 Lys63-specific deubiquitinase activity
GO:0070062 extracellular exosome
GO:0070301 cellular response to hydrogen peroxide
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070429 negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding
GO:0070536 protein K63-linked deubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0071108 protein K48-linked deubiquitination
GO:0071222 cellular response to lipopolysaccharide
GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072573 tolerance induction to lipopolysaccharide
GO:0072666 establishment of protein localization to vacuole
GO:0090291 negative regulation of osteoclast proliferation
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903364 positive regulation of cellular protein catabolic process
GO:1990168 protein K33-linked deubiquitination
GO:2000347 positive regulation of hepatocyte proliferation
GO:2000349 negative regulation of CD40 signaling pathway
GO:2000352 negative regulation of endothelial cell apoptotic process

Subcellular Location

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Subcellular Location
Cytoplasm
Lysosome
Nucleus

Domains

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DomainNameCategoryType
IPR002653 Zinc finger, A20-typeDomainDomain
IPR003323 OTU domainDomainDomain
IPR033478 A20 peptidaseFamilyFamily

Diseases

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Interactions

90 interactions

InteractorPartnerSourcesPublicationsLink
TNAP3_HUMANNEMO_HUMANBioGRID, HPRD, IntAct, MINT10755617 11389905 21988832 22099304 23032186 26802121 30561431 31585000 details
TNAP3_HUMANTNAP3_HUMANBioGRID, HPRD, IntAct, MINT11389905 15258597 24008839 25165885 25416956 25502805 28244869 30561431 31515488 32296183 8692885 8797804 details
TNAP3_HUMANTNIP1_HUMANBioGRID, HPRD, IntAct, MINT10385526 11389905 12586352 12965196 18029035 21988832 25165885 25416956 30561431 31515488 32296183 details
TNAP3_HUMANTNIP2_HUMANBioGRID, HPRD, IntAct, MINT10385526 11389905 11390377 15169888 18029035 21266526 30561431 details
TNAP3_HUMANTAXB1_HUMANBioGRID, HPRD, IntAct, MINT10435631 11389905 23018911 28514442 30561431 32296183 details
TNAP3_HUMANTRAF6_HUMANBioGRID, HPRD, IntAct11463333 15334086 18164316 20622874 21220427 23018911 23105109 23737552 28244869 29720226 31625129 32015333 9928991 details
TNAP3_HUMANRNF11_HUMANBioGRID, HPRD, MINT15231748 19131965 22507528 23018911 details
TNAP3_HUMANLAPM5_HUMANBioGRID, HPRD, MINT15231748 22733818 details
TNAP3_HUMANUBC_HUMANBioGRID, MINT14748687 15334086 18029035 19285159 19373254 20622874 21095585 22099304 23032186 23032187 23827681 27732584 details
TNAP3_HUMAN1433G_HUMANBioGRID, HPRD, IntAct20936779 8702721 details
TNAP3_HUMAN1433E_HUMANBioGRID, HPRD, IntAct21988832 8702721 details
TNAP3_HUMAN1433Z_HUMANBioGRID, HPRD, IntAct20936779 21988832 8702721 9299557 details
TNAP3_HUMANGIT2_HUMANBioGRID, IntAct21988832 details
TNAP3_HUMANTNFA_HUMANBioGRID, IntAct, MINT22099304 23032186 23032187 25911380 26670046 27307491 27545878 30561431 details
TNAP3_HUMANHOIL1_HUMANBioGRID, MINT23032186 23105109 details
TNAP3_HUMANTRI23_HUMANBioGRID, IntAct25416956 32296183 details
TNAP3_HUMANTRAF2_HUMANBioGRID, HPRD, IntAct10544141 24008839 25416956 30561431 31515488 32296183 8692885 details
TNAP3_HUMANARRD3_HUMANBioGRID, IntAct25416956 32296183 details
TNAP3_HUMANTNIP3_HUMANBioGRID, IntAct17088249 25416956 details
TNAP3_HUMANLNX1_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANDRC4_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANRD23A_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANRN216_HUMANBioGRID, IntAct32296183 details
TNAP3_HUMANRN114_HUMANBioGRID, IntAct25165885 28514442 details
TNAP3_HUMANCASP8_HUMANBioGRID, DIP19060883 26437781 28574503 details
TNAP3_HUMANIKKB_HUMANBioGRID, DIP, HPRD11594795 21220427 26649818 details
TNAP3_HUMANRIPK1_HUMANBioGRID, HPRD, IntAct15258597 18246070 19131965 22585859 29274253 30561431 32015333 details
TNAP3_HUMANTRAF1_HUMANBioGRID, HPRD25996949 8692885 9928991 details
TNAP3_HUMAN1433F_HUMANBioGRID, HPRD19615732 8702721 9299557 details
TNAP3_HUMAN1433B_HUMANBioGRID, HPRD18029035 19615732 8702721 details
TNAP3_HUMANM3K5_HUMANBioGRID20448643 29227477 details
TNAP3_HUMANCCD50_HUMANBioGRID, HPRD18029035 details
TNAP3_HUMANUBE2N_HUMANBioGRID15258597 details
TNAP3_HUMANTRIM2_HUMANBioGRID23105109 details
TNAP3_HUMANRNF5_HUMANBioGRID23105109 details
TNAP3_HUMANRNF14_HUMANBioGRID23105109 details
TNAP3_HUMANRNF12_HUMANBioGRID23105109 details
TNAP3_HUMANTRIM3_HUMANBioGRID23105109 details
TNAP3_HUMANTRIM8_HUMANBioGRID23105109 details
TNAP3_HUMANTRIM5_HUMANBioGRID23105109 details
TNAP3_HUMANOCLN_HUMANBioGRID22031828 details
TNAP3_HUMAN1433T_HUMANBioGRID25165885 details
TNAP3_HUMANUB2D1_HUMANBioGRID15258597 28892081 details
TNAP3_HUMANSNAI1_HUMANBioGRID28892081 details
TNAP3_HUMANDPTOR_HUMANBioGRID29940800 details
TNAP3_HUMANRN168_HUMANBioGRID29233925 details
TNAP3_HUMANPIBF1_HUMANBioGRID32296183 details
TNAP3_HUMANGSK3B_HUMANBioGRID31471107 details
TNAP3_HUMANCEBPB_HUMANBioGRID31471107 details
TNAP3_HUMANPFKAL_HUMANBioGRID32015333 details
TNAP3_HUMANTCAM1_HUMANBioGRID, HPRD, MINT15474016 details
TNAP3_HUMANKRR1_HUMANMINT19131965 details
TNAP3_HUMANWNK1_HUMANIntAct20936779 details
TNAP3_HUMANHS90B_HUMANIntAct22939624 details
TNAP3_HUMANRNF31_HUMANBioGRID, IntAct, MINT23032186 23032187 27545878 30561431 details
TNAP3_HUMANFADD_HUMANBioGRID, IntAct20448643 26437781 30561431 details
TNAP3_HUMANTBK1_HUMANBioGRID, IntAct15661910 19615732 21885437 30561431 details
TNAP3_HUMANBIRC2_HUMANBioGRID, IntAct24008839 30561431 32015333 details
TNAP3_HUMANTNR1A_HUMANBioGRID, IntAct20448643 24098568 26802121 30420664 30561431 31406107 details
TNAP3_HUMANIKKA_HUMANBioGRID, HPRD11594795 details
TNAP3_HUMANLAMP1_HUMANBioGRID18329387 details
TNAP3_HUMANPLAT4_HUMANBioGRID16306043 details
TNAP3_HUMANBECN1_HUMANBioGRID20501938 details
TNAP3_HUMANIRAK1_HUMANBioGRID21220427 details
TNAP3_HUMANIRAK2_HUMANBioGRID21220427 details
TNAP3_HUMANIRF7_HUMANBioGRID20392859 details
TNAP3_HUMANIKKE_HUMANBioGRID15661910 21885437 details
TNAP3_HUMANTNF10_HUMANBioGRID22585859 details
TNAP3_HUMANTR10B_HUMANBioGRID22585859 details
TNAP3_HUMANHS90A_HUMANBioGRID22939624 details
TNAP3_HUMANP53_HUMANBioGRID23471665 24099634 details
TNAP3_HUMANAXIN1_HUMANBioGRID23671587 details
TNAP3_HUMANNFKB2_HUMANBioGRID24008839 details
TNAP3_HUMANBIRC3_HUMANBioGRID24008839 details
TNAP3_HUMANMALT1_HUMANBioGRID24491438 details
TNAP3_HUMANMTOR_HUMANBioGRID26043155 29940800 details
TNAP3_HUMANNOD2_HUMANBioGRID26670046 details
TNAP3_HUMANNFKB1_HUMANBioGRID28923245 details
TNAP3_HUMANCUL3_HUMANBioGRID28574503 details
TNAP3_HUMANSQSTM_HUMANBioGRID28574503 details
TNAP3_HUMANPRGC1_HUMANBioGRID29678181 details
TNAP3_HUMANTLR9_HUMANBioGRID30277474 details
TNAP3_HUMANSMAD6_HUMANBioGRID29720226 details
TNAP3_HUMANPELI1_HUMANBioGRID29720226 details
TNAP3_HUMANTR10A_HUMANBioGRID29274253 details
TNAP3_HUMANCTNB1_HUMANBioGRID30323974 details
TNAP3_HUMANGRN_HUMANBioGRID31585000 details
TNAP3_HUMANSTAT3_HUMANBioGRID31958753 details
TNAP3_HUMANACSL4_HUMANBioGRID31160087 details
TNAP3_HUMANZFAN5_HUMANHPRD14754897 details