Entity Details

Primary name DRD1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP21728
EntryNameDRD1_HUMAN
FullNameD(1A) dopamine receptor
TaxID9606
Evidenceevidence at protein level
Length446
SequenceStatuscomplete
DateCreated1991-05-01
DateModified2021-06-02

Ontological Relatives

GenesDRD1

GO terms

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GOName
GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0004930 G protein-coupled receptor activity
GO:0004952 dopamine neurotransmitter receptor activity
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007416 synapse assembly
GO:0007617 mating behavior
GO:0007628 adult walking behavior
GO:0008542 visual learning
GO:0010628 positive regulation of gene expression
GO:0019226 transmission of nerve impulse
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0030335 positive regulation of cell migration
GO:0035240 dopamine binding
GO:0042311 vasodilation
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0043197 dendritic spine
GO:0043268 positive regulation of potassium ion transport
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060134 prepulse inhibition
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060170 ciliary membrane
GO:0071870 cellular response to catecholamine stimulus
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway
GO:0097730 non-motile cilium
GO:1903351 cellular response to dopamine

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Endoplasmic reticulum membrane

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000929 Dopamine receptor familyFamilyFamily
IPR001413 Dopamine D1 receptorFamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB00246 ZiprasidoneDrugbanksmall molecule
DB00248 CabergolineDrugbanksmall molecule
DB00334 OlanzapineDrugbanksmall molecule
DB00353 MethylergometrineDrugbanksmall molecule
DB00363 ClozapineDrugbanksmall molecule
DB00397 PhenylpropanolamineDrugbanksmall molecule
DB00408 LoxapineDrugbanksmall molecule
DB00458 ImipramineDrugbanksmall molecule
DB00477 ChlorpromazineDrugbanksmall molecule
DB00502 HaloperidolDrugbanksmall molecule
DB00508 TriflupromazineDrugbanksmall molecule
DB00543 AmoxapineDrugbanksmall molecule
DB00555 LamotrigineDrugbanksmall molecule
DB00568 CinnarizineDrugbanksmall molecule
DB00589 LisurideDrugbanksmall molecule
DB00623 FluphenazineDrugbanksmall molecule
DB00679 ThioridazineDrugbanksmall molecule
DB00696 ErgotamineDrugbanksmall molecule
DB00714 ApomorphineDrugbanksmall molecule
DB00715 ParoxetineDrugbanksmall molecule
DB00726 TrimipramineDrugbanksmall molecule
DB00734 RisperidoneDrugbanksmall molecule
DB00800 FenoldopamDrugbanksmall molecule
DB00805 MinaprineDrugbanksmall molecule
DB00850 PerphenazineDrugbanksmall molecule
DB00875 FlupentixolDrugbanksmall molecule
DB00988 DopamineDrugbanksmall molecule
DB01038 CarphenazineDrugbanksmall molecule
DB01049 Ergoloid mesylateDrugbanksmall molecule
DB01186 PergolideDrugbanksmall molecule
DB01200 BromocriptineDrugbanksmall molecule
DB01224 QuetiapineDrugbanksmall molecule
DB01235 LevodopaDrugbanksmall molecule
DB01238 AripiprazoleDrugbanksmall molecule
DB01239 ChlorprothixeneDrugbanksmall molecule
DB01267 PaliperidoneDrugbanksmall molecule
DB01403 MethotrimeprazineDrugbanksmall molecule
DB01608 PericiazineDrugbanksmall molecule
DB01614 AcepromazineDrugbanksmall molecule
DB01621 PipotiazineDrugbanksmall molecule
DB01622 ThioproperazineDrugbanksmall molecule
DB01623 ThiothixeneDrugbanksmall molecule
DB01624 ZuclopenthixolDrugbanksmall molecule
DB04946 IloperidoneDrugbanksmall molecule
DB05271 RotigotineDrugbanksmall molecule
DB06077 LumateperoneDrugbanksmall molecule
DB06148 MianserinDrugbanksmall molecule
DB06216 AsenapineDrugbanksmall molecule
DB09097 QuinagolideDrugbanksmall molecule
DB09225 ZotepineDrugbanksmall molecule
DB09286 PipamperoneDrugbanksmall molecule
DB11274 Dihydro-alpha-ergocryptineDrugbanksmall molecule
DB11275 EpicriptineDrugbanksmall molecule
DB11584 PipradrolDrugbanksmall molecule
DB12093 TetrahydropalmatineDrugbanksmall molecule
DB12890 DihydrexidineDrugbanksmall molecule
DB13345 DihydroergocristineDrugbanksmall molecule
DB14185 Aripiprazole lauroxilDrugbanksmall molecule