Entity Details

Primary name UBA1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP22314
EntryNameUBA1_HUMAN
FullNameUbiquitin-like modifier-activating enzyme 1
TaxID9606
Evidenceevidence at protein level
Length1058
SequenceStatuscomplete
DateCreated1991-08-01
DateModified2021-06-02

Ontological Relatives

GenesUBA1

GO terms

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GOName
GO:0003723 RNA binding
GO:0004839 ubiquitin activating enzyme activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016567 protein ubiquitination
GO:0032446 protein modification by small protein conjugation
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion
Nucleus

Domains

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DomainNameCategoryType
IPR000011 Ubiquitin/SUMO-activating enzyme E1FamilyFamily
IPR000594 THIF-type NAD/FAD binding foldDomainDomain
IPR018074 Ubiquitin-activating enzyme E1, conserved siteSiteConserved site
IPR018075 Ubiquitin-activating enzyme E1FamilyFamily
IPR018965 Ubiquitin-activating enzyme E1, C-terminalDomainDomain
IPR019572 Ubiquitin-activating enzyme, SCCH domainDomainDomain
IPR032418 Ubiquitin-activating enzyme E1, FCCH domainDomainDomain
IPR032420 Ubiquitin-activating enzyme E1, four-helix bundleDomainDomain
IPR033127 Ubiquitin-activating enzyme E1, Cys active siteSiteActive site
IPR035985 Ubiquitin-activating enzymeFamilyHomologous superfamily
IPR038252 Ubiquitin-activating enzyme E1, C-terminal domain superfamilyFamilyHomologous superfamily
IPR042063 Ubiquitin-activating enzyme E1, SCCH domainFamilyHomologous superfamily
IPR042302 Ubiquitin-activating enzyme E1, FCCH domain superfamilyFamilyHomologous superfamily
IPR042449 Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1FamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
301830 OMIMSpinal muscular atrophy X-linked 2 (SMAX2)A lethal infantile form of spinal muscular atrophy, a neuromuscular disorder characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. Clinical features include hypotonia, areflexia, and multiple congenital contractures. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB04119 Hexatantalum DodecabromideDrugbanksmall molecule
DB04216 QuercetinDrugbanksmall molecule

Interactions

72 interactions

InteractorPartnerSourcesPublicationsLink
UBA1_HUMANTMCC2_HUMANHPRD, IntAct16169070 details
UBA1_HUMANSEM3F_HUMANHPRD, IntAct16169070 details
UBA1_HUMANTSSC4_HUMANHPRD, IntAct16169070 details
UBA1_HUMANGAN_HUMANBioGRID, HPRD, IntAct16227972 details
UBA1_HUMANTAF9_HUMANBioGRID, HPRD, IntAct16713569 details
UBA1_HUMANUB2J1_HUMANBioGRID, IntAct17597759 19549727 31518855 details
UBA1_HUMANECHM_HUMANBioGRID, IntAct21988832 details
UBA1_HUMANGRB2_HUMANBioGRID, IntAct21988832 details
UBA1_HUMANBUB3_HUMANBioGRID, IntAct21988832 details
UBA1_HUMANPIAS3_HUMANBioGRID, MINT21900206 details
UBA1_HUMANSMAD5_HUMANBioGRID, MINT21900206 details
UBA1_HUMANTTC19_HUMANBioGRID, MINT21900206 details
UBA1_HUMANUB2E1_HUMANBioGRID, IntAct16428300 17597759 22069333 25260751 25527291 27425610 29034082 8576257 details
UBA1_HUMANUB2D3_HUMANBioGRID, IntAct17597759 22069333 25207809 25260751 27425610 32246052 details
UBA1_HUMANUB2E2_HUMANBioGRID, IntAct17597759 22069333 25260751 30097011 30279270 details
UBA1_HUMANHGS_HUMANBioGRID, IntAct19019082 25260751 details
UBA1_HUMANOTUB1_HUMANIntAct26752685 32814053 details
UBA1_HUMANMTR1A_HUMANBioGRID, IntAct26514267 details
UBA1_HUMANUBE2N_HUMANBioGRID, IntAct14517261 18678647 25527291 27173435 27182664 29537486 30097011 31638574 unassigned1312 details
UBA1_HUMANWWP2_HUMANIntAct32814053 details
UBA1_HUMANTRAF4_HUMANIntAct32814053 details
UBA1_HUMANHD_HUMANIntAct32814053 details
UBA1_HUMANHS105_HUMANBioGRID, HPRD14733918 details
UBA1_HUMANUBC_HUMANBioGRID17550899 17980597 23003343 24816100 27182664 28190767 30279270 details
UBA1_HUMANUBE2B_HUMANBioGRID17597759 21041297 22069333 25527291 27425610 30279270 31873223 details
UBA1_HUMANUB2R1_HUMANBioGRID17597759 22069333 24912152 25527291 30097011 details
UBA1_HUMANUB2D1_HUMANBioGRID11807090 17597759 22069333 25527291 27425610 30097011 details
UBA1_HUMANUB2D2_HUMANBioGRID11807090 17597759 19250909 21041297 22069333 25275296 27182664 27425610 28134249 29326975 29643511 30097011 30279270 details
UBA1_HUMANUB2L3_HUMANBioGRID11807090 17597759 19250909 22069333 22350887 25026213 25527291 27182664 27425610 28924046 29263404 29643511 30097011 30246024 30279270 30587574 8576257 details
UBA1_HUMANUB2E3_HUMANBioGRID17597759 22069333 details
UBA1_HUMANUBE2S_HUMANBioGRID17597759 22069333 25527291 27425610 30097011 30279270 31230944 33082289 details
UBA1_HUMANUBE2A_HUMANBioGRID17597759 22427669 25527291 27425610 31887036 details
UBA1_HUMANUBE2K_HUMANBioGRID17597759 2265617 27425610 30097011 30336976 32101714 8125920 9857030 details
UBA1_HUMANUB2R2_HUMANBioGRID17597759 27425610 30097011 details
UBA1_HUMANUBE2H_HUMANBioGRID17597759 27425610 30097011 details
UBA1_HUMANUBE2W_HUMANBioGRID17597759 25527291 27425610 30097011 details
UBA1_HUMANUBE2C_HUMANBioGRID11807090 17597759 19250909 30097011 details
UBA1_HUMANUBE2T_HUMANBioGRID17597759 27425610 30279270 31873223 details
UBA1_HUMANUB2G1_HUMANBioGRID17597759 30097011 30279270 details
UBA1_HUMANUB2G2_HUMANBioGRID17597759 25527291 27425610 30097011 31518855 details
UBA1_HUMANUBTD2_HUMANBioGRID25207809 details
UBA1_HUMANUBA1_HUMANBioGRID22350887 details
UBA1_HUMANUB2L6_HUMANBioGRID30097011 9153201 details
UBA1_HUMANUB2D4_HUMANBioGRID25527291 27425610 30097011 details
UBA1_HUMANUB2Q2_HUMANBioGRID25527291 27425610 30097011 details
UBA1_HUMANCHK1_HUMANBioGRID26296656 details
UBA1_HUMANUBE2Z_HUMANBioGRID25768649 27425610 details
UBA1_HUMANUBC12_HUMANBioGRID28581483 31157974 details
UBA1_HUMANUB2J2_HUMANBioGRID27425610 details
UBA1_HUMANUBE2U_HUMANBioGRID30097011 details
UBA1_HUMANABCF1_HUMANBioGRID30770245 details
UBA1_HUMANSUMO2_HUMANBioGRID32786267 details
UBA1_HUMANOGT1_HUMANBioGRID32994395 details
UBA1_HUMAN1433Z_HUMANMINT15161933 details
UBA1_HUMANUBC9_HUMANIntAct17956732 details
UBA1_HUMANDISC1_HUMANIntAct31413325 details
UBA1_HUMANHDAC5_HUMANBioGRID21081666 details
UBA1_HUMANUBD_HUMANBioGRID22434192 details
UBA1_HUMANRD23B_HUMANBioGRID16712842 details
UBA1_HUMANRD23A_HUMANBioGRID16712842 31536960 details
UBA1_HUMANHS90A_HUMANBioGRID16263121 details
UBA1_HUMANEFMT3_HUMANBioGRID23349634 details
UBA1_HUMANUBP5_HUMANBioGRID25207809 details
UBA1_HUMANFUS_HUMANBioGRID25192599 details
UBA1_HUMANPSDE_HUMANBioGRID24743594 details
UBA1_HUMANIBTK_HUMANBioGRID25882842 details
UBA1_HUMANITCH_HUMANBioGRID26508657 details
UBA1_HUMANU2AF2_HUMANBioGRID26641092 details
UBA1_HUMANEDEM3_HUMANBioGRID28366632 details
UBA1_HUMANMEX3C_HUMANBioGRID30631154 details
UBA1_HUMANCDK1_HUMANHPRD7673335 7724583 details
UBA1_HUMANMGMT_HUMANHPRD8573590 details