Entity Details

Primary name BDNF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP23560
EntryNameBDNF_HUMAN
FullNameBrain-derived neurotrophic factor
TaxID9606
Evidenceevidence at protein level
Length247
SequenceStatuscomplete
DateCreated1991-11-01
DateModified2021-06-02

Ontological Relatives

GenesBDNF

GO terms

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GOName
GO:0005163 nerve growth factor receptor binding
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007416 synapse assembly
GO:0007422 peripheral nervous system development
GO:0007613 memory
GO:0008021 synaptic vesicle
GO:0008083 growth factor activity
GO:0010832 negative regulation of myotube differentiation
GO:0010976 positive regulation of neuron projection development
GO:0016607 nuclear speck
GO:0021675 nerve development
GO:0030424 axon
GO:0030425 dendrite
GO:0031547 brain-derived neurotrophic factor receptor signaling pathway
GO:0031550 positive regulation of brain-derived neurotrophic factor receptor signaling pathway
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0038180 nerve growth factor signaling pathway
GO:0043524 negative regulation of neuron apoptotic process
GO:0045664 regulation of neuron differentiation
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048471 perinuclear region of cytoplasm
GO:0048668 collateral sprouting
GO:0048672 positive regulation of collateral sprouting
GO:0048812 neuron projection morphogenesis
GO:0050804 modulation of chemical synaptic transmission
GO:0051965 positive regulation of synapse assembly
GO:1900122 positive regulation of receptor binding
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:2000008 regulation of protein localization to cell surface
GO:2001234 negative regulation of apoptotic signaling pathway

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR002072 Nerve growth factor-relatedDomainDomain
IPR019846 Nerve growth factor conserved siteSiteConserved site
IPR020408 Nerve growth factor-likeFamilyFamily
IPR020430 Brain-derived neurotrophic factorFamilyFamily
IPR029034 Cystine-knot cytokineFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05047 CX-717Drugbanksmall molecule
DB09130 CopperDrugbanksmall molecule
DB09301 Chondroitin sulfateDrugbanksmall molecule
DB11823 EsketamineDrugbanksmall molecule

Interactions

68 interactions

InteractorPartnerSourcesPublicationsLink
BDNF_HUMANNTF3_HUMANBioGRID, HPRD, IntAct7703225 details
BDNF_HUMANJUNB_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANJAM1_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANINP5K_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANAGO3_HUMANBioGRID, IntAct21988832 details
BDNF_HUMANNTF4_HUMANBioGRID, IntAct10631974 25241761 29997244 details
BDNF_HUMANSORC2_HUMANbhf-ucl24908487 details
BDNF_HUMANF209A_HUMANBioGRID, IntAct32296183 details
BDNF_HUMANSORT_HUMANBioGRID, DIP, HPRD, IntAct15987945 19122660 20159974 21357693 32296183 details
BDNF_HUMANGP152_HUMANBioGRID, IntAct32296183 details
BDNF_HUMANCREB3_HUMANIntAct31515488 details
BDNF_HUMANCYH1_HUMANIntAct32814053 details
BDNF_HUMANFKBP6_HUMANIntAct32814053 details
BDNF_HUMANTHIO_HUMANIntAct32814053 details
BDNF_HUMANPRPS1_HUMANIntAct32814053 details
BDNF_HUMANKAPCA_HUMANIntAct32814053 details
BDNF_HUMANLBP_HUMANIntAct32814053 details
BDNF_HUMANHXA3_HUMANIntAct32814053 details
BDNF_HUMANFYN_HUMANIntAct32814053 details
BDNF_HUMANFUT2_HUMANIntAct32814053 details
BDNF_HUMANHYEP_HUMANIntAct32814053 details
BDNF_HUMANDNSL1_HUMANIntAct32814053 details
BDNF_HUMANCTNB1_HUMANIntAct32814053 details
BDNF_HUMANDPYL1_HUMANIntAct32814053 details
BDNF_HUMANKCC2A_HUMANIntAct32814053 details
BDNF_HUMANRM49_HUMANIntAct32814053 details
BDNF_HUMANRAGE_HUMANIntAct32814053 details
BDNF_HUMANBTBD1_HUMANIntAct32814053 details
BDNF_HUMANGALA_HUMANIntAct32814053 details
BDNF_HUMANKAD3_HUMANIntAct32814053 details
BDNF_HUMANHCST_HUMANIntAct32814053 details
BDNF_HUMANEXOC5_HUMANIntAct32814053 details
BDNF_HUMANKAT5_HUMANIntAct32814053 details
BDNF_HUMANDHRS9_HUMANIntAct32814053 details
BDNF_HUMANUBE3C_HUMANIntAct32814053 details
BDNF_HUMANSNX20_HUMANIntAct32814053 details
BDNF_HUMANMRAP2_HUMANIntAct32814053 details
BDNF_HUMANCCD32_HUMANIntAct32814053 details
BDNF_HUMANHSFY1_HUMANIntAct32814053 details
BDNF_HUMANCORO6_HUMANIntAct32814053 details
BDNF_HUMANAPH1B_HUMANIntAct32814053 details
BDNF_HUMANWDCP_HUMANIntAct32814053 details
BDNF_HUMANTLE6_HUMANIntAct32814053 details
BDNF_HUMANRUSF1_HUMANIntAct32814053 details
BDNF_HUMANGMCL2_HUMANIntAct32814053 details
BDNF_HUMANS41A3_HUMANIntAct32814053 details
BDNF_HUMANPLPR1_HUMANIntAct32814053 details
BDNF_HUMANANKH1_HUMANIntAct32814053 details
BDNF_HUMANATL4_HUMANIntAct32814053 details
BDNF_HUMANCTL5_HUMANIntAct32814053 details
BDNF_HUMANZC3H1_HUMANIntAct32814053 details
BDNF_HUMANCCD26_HUMANIntAct32814053 details
BDNF_HUMANCDK5_HUMANIntAct32814053 details
BDNF_HUMANA4_HUMANBioGRID, IntAct21832049 32814053 details
BDNF_HUMANNTRK2_HUMANBioGRID, HPRD11855816 21651720 9312147 details
BDNF_HUMANRHOU_HUMANBioGRID26598620 details
BDNF_HUMANHAP1_HUMANBioGRID21357693 details
BDNF_HUMANLRP1_HUMANBioGRID7537086 details
BDNF_HUMANDNMT1_HUMANBioGRID25476119 details
BDNF_HUMANTET1_HUMANBioGRID25476119 details
BDNF_HUMANMBD2_HUMANBioGRID25476119 details
BDNF_HUMANNCAM1_HUMANHPRD10760298 details
BDNF_HUMANESR1_HUMANHPRD11923430 details
BDNF_HUMANNOS3_HUMANHPRD10493752 details
BDNF_HUMANMBTP1_HUMANHPRD9990022 details
BDNF_HUMANCBPE_HUMANHPRD15664176 details
BDNF_HUMANBDNF_HUMANHPRD7961712 8174548 details
BDNF_HUMANCAPS2_HUMANHPRD14715936 details