Entity Details

Primary name ARBK1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP25098
EntryNameARBK1_HUMAN
FullNameBeta-adrenergic receptor kinase 1
TaxID9606
Evidenceevidence at protein level
Length689
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesGRK2

GO terms

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GOName
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0003108 negative regulation of the force of heart contraction by chemical signal
GO:0004672 protein kinase activity
GO:0004703 G protein-coupled receptor kinase activity
GO:0005524 ATP binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007507 heart development
GO:0016020 membrane
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0019079 viral genome replication
GO:0031623 receptor internalization
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031755 Edg-2 lysophosphatidic acid receptor binding
GO:0033605 positive regulation of catecholamine secretion
GO:0045202 synapse
GO:0045988 negative regulation of striated muscle contraction
GO:0046718 viral entry into host cell
GO:0047696 beta-adrenergic receptor kinase activity
GO:0060048 cardiac muscle contraction
GO:1901081 negative regulation of relaxation of smooth muscle

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm

Domains

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DomainNameCategoryType
IPR000239 GPCR kinaseFamilyFamily
IPR000719 Protein kinase domainDomainDomain
IPR000961 AGC-kinase, C-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016137 RGS domainDomainDomain
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR036305 RGS domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00171 ATPDrugbanksmall molecule

Interactions

70 interactions

InteractorPartnerSourcesPublicationsLink
ARBK1_HUMANEPHA2_HUMANBioGRID, IntAct21988832 details
ARBK1_HUMANRGRF1_HUMANBioGRID, IntAct21988832 details
ARBK1_HUMANCSK2B_HUMANBioGRID, MINT21900206 details
ARBK1_HUMANHDAC6_HUMANBioGRID, MINT22193721 details
ARBK1_HUMANTBB5_HUMANMINT24813628 details
ARBK1_HUMANIKBA_HUMANDIP19008357 details
ARBK1_HUMANAPJ_HUMANIntAct30409826 details
ARBK1_HUMANERBB2_HUMANBioGRID, IntAct31980649 details
ARBK1_HUMANNCAM1_HUMANIntAct32814053 details
ARBK1_HUMANERBB3_HUMANIntAct32814053 details
ARBK1_HUMANKC1D_HUMANIntAct32814053 details
ARBK1_HUMANA4_HUMANIntAct32814053 details
ARBK1_HUMANGNAQ_HUMANBioGRID, HPRD10567430 10727532 12885252 21940795 details
ARBK1_HUMANGNA15_HUMANBioGRID12885252 details
ARBK1_HUMANKPCB_HUMANBioGRID, HPRD12456365 12679936 29054428 details
ARBK1_HUMANCNRG_HUMANBioGRID, HPRD12624098 details
ARBK1_HUMANPHLP_HUMANBioGRID, HPRD10884381 details
ARBK1_HUMANPHOS_HUMANBioGRID, HPRD10884381 details
ARBK1_HUMANGIT2_HUMANBioGRID, HPRD10896954 details
ARBK1_HUMANOPSD_HUMANBioGRID, HPRD10722682 details
ARBK1_HUMANCAV1_HUMANBioGRID, HPRD10085129 details
ARBK1_HUMANFSHR_HUMANBioGRID, HPRD10379886 details
ARBK1_HUMANADRB2_HUMANBioGRID11309381 14654844 8672451 details
ARBK1_HUMANGBB1_HUMANBioGRID10744734 15102938 17548351 details
ARBK1_HUMANCSEN_HUMANBioGRID17102134 details
ARBK1_HUMANSYUA_HUMANBioGRID, HPRD10617630 10852916 17893145 details
ARBK1_HUMANFBX25_HUMANBioGRID23940030 details
ARBK1_HUMANGBB2_HUMANBioGRID25982117 details
ARBK1_HUMANARRB2_HUMANBioGRID29054428 details
ARBK1_HUMANGBB3_HUMANBioGRID27462452 details
ARBK1_HUMANPK3CB_HUMANBioGRID12163475 details
ARBK1_HUMANPLCB1_HUMANBioGRID10567430 details
ARBK1_HUMANEGFR_HUMANBioGRID, HPRD, MINT15620700 28579429 details
ARBK1_HUMANMDM2_HUMANBioGRID, HPRD, MINT17006543 21081496 26228571 30703414 details
ARBK1_HUMANUBC_HUMANMINT17006543 details
ARBK1_HUMANGIT1_HUMANBioGRID, HPRD, MINT10896954 18369319 9826657 details
ARBK1_HUMANFPR1_HUMANHPRD, InnateDB22447027 7836371 details
ARBK1_HUMANCDC37_HUMANIntAct25036637 details
ARBK1_HUMANPTC1_HUMANBioGRID, DIP19502428 26885983 31253779 details
ARBK1_HUMANSRC_HUMANBioGRID, HPRD12624098 details
ARBK1_HUMANCCR4_HUMANBioGRID, HPRD10754297 details
ARBK1_HUMANEDNRB_HUMANBioGRID9211925 details
ARBK1_HUMANAGTR1_HUMANBioGRID, HPRD8662816 9211925 details
ARBK1_HUMANPGFRB_HUMANBioGRID12381737 details
ARBK1_HUMANARRB1_HUMANBioGRID, HPRD21081496 8885248 details
ARBK1_HUMANGRM1_HUMANBioGRID16091361 details
ARBK1_HUMANPEBP1_HUMANBioGRID, HPRD14654844 details
ARBK1_HUMANGPR17_HUMANBioGRID26228571 details
ARBK1_HUMANVDR_HUMANBioGRID28579429 details
ARBK1_HUMANSMO_HUMANBioGRID31253779 details
ARBK1_HUMANTRAF2_HUMANBioGRID31986892 details
ARBK1_HUMANMALT1_HUMANBioGRID31961340 details
ARBK1_HUMANBKRB2_HUMANHPRD11517230 details
ARBK1_HUMANCAN2_HUMANHPRD12130691 details
ARBK1_HUMANMC4R_HUMANHPRD12639913 details
ARBK1_HUMANOPRD_HUMANHPRD11040053 details
ARBK1_HUMANKPCA_HUMANHPRD11042191 details
ARBK1_HUMANKPCD_HUMANHPRD11042191 details
ARBK1_HUMANKPCG_HUMANHPRD11042191 details
ARBK1_HUMANRECO_HUMANHPRD12507501 details
ARBK1_HUMANRLA2_HUMANHPRD12379128 14729942 14997482 details
ARBK1_HUMANPK3CG_HUMANHPRD12163475 details
ARBK1_HUMANKAPCA_HUMANHPRD11278469 details
ARBK1_HUMANMK03_HUMANHPRD10574913 10727525 details
ARBK1_HUMANNCS1_HUMANHPRD12351722 details
ARBK1_HUMANAKA12_HUMANHPRD11309381 details
ARBK1_HUMANCCR5_HUMANHPRD10085131 details
ARBK1_HUMANEGF_HUMANHPRD15620700 details
ARBK1_HUMANTPM2_HUMANHPRD16094730 details
ARBK1_HUMANADA2A_HUMANHPRD7876239 details